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Table 3 Effect of total flavonoids in Stellera chamaejasme L. on serum lipid level in rats (mean ± SD) (n = 20)

From: Prevention and treatment effect of total flavonoids in Stellera chamaejasme L. on nonalcoholic fatty liver in rats

Parameter

4w

6w

Normal group

NAFLD group

Normal group

Low-dose group

Middle-dose group

High-dose group

Positive control group

AST (U/L)

75.17 ± 4.31

96.85 ± 7.63

76.29 ± 5.16

97.36 ± 6.82**

93.75 ± 4.55*

88.34 ± 6.27*#

101.67 ± 8.36

ALT(U/L)

28.16 ± 1.21

51.28 ± 3.26

29.25 ± 1.72

53.28 ± 4.41**

49.78 ± 2.19**

44.29 ± 2.22**#

56.35 ± 4.16

TG(mmol/L)

0.59 ± 0.09

1.65 ± 0.08

0.61 ± 0.04

1.81 ± 0.11**

1.46 ± 0.09**#

0.92 ± 0.03**##

2.12 ± 0.12

TC(mmol/L)

1.66 ± 0.12

3.14 ± 0.13

1.70 ± 0.09

3.82 ± 0.15**

3.65 ± 0.17**#

2.65 ± 0.12**##

4.54 ± 0.24

LDL-C (mmol/L)

0.54 ± 0.03

1.25 ± 0.08

0.56 ± 0.04

1.37 ± 0.08**

1.24 ± 0.05**

1.09 ± 0.06**#

1.35 ± 0.09

HDL-C (mmol/L)

0.96 ± 0.04

0.64 ± 0.04

0.98 ± 0.05

0.64 ± 0.03**

0.69 ± 0.05**

0.77 ± 0.04*#

0.55 ± 0.03

GLU (mmol/L)

4.68 ± 0.15

5.07 ± 0.21

4.56 ± 0.18

4.99 ± 0.87

5.07 ± 0.04

5.13 ± 18.88

5.41 ± 0.19

TBA(μmol/L)

6.75 ± 0.05

10.23 ± 0.06

6.54 ± 0.06

11.53 ± 1.27**

11.04 ± 0.98**

10.24 ± 0.05**#

12.27 ± 1.25

Leptin (μg/L)

0.18 ± 0.01

0.32 ± 0.01

0.19 ± 0.02

0.46 ± 0.03**

0.34 ± 0.02*#

0.28 ± 0.01#

0.46 ± 0.03

SOD (U/mL)

374.36 ± 17.86

300.4 ± 20.1

370.35 ± 19.46

293.4 ± 24.1**

321.79 ± 23.16*

348.32 ± 19.76#

297.84 ± 23.17

MDA (nmol/mL)

3.26 ± 0.21

4.27 ± 0.16

3.25 ± 0.75

4.98 ± 1.32*

4.77 ± 0.87*

3.84 ± 0.99##

5.04 ± 1.27

GSH-Px (U/mL)

256.21 ± 19.25

210.45 ± 14.2

255.98 ± 20.54

206.88 ± 15.3**

211.57 ± 17.45**#

238.78 ± 14.25#

194.21 ± 17.35

  1. P < 0.05, P < 0.01, compared to normal control group (4w). *P < 0.05, **P < 0.01, compared to normal group (6w); # P < 0.05, ## P < 0.01, compared to positive control group (6w). Normal Group: the group was given normal diet (n = 20) for 4 weeks; NAFLD Group: the group was given high-fat diet (n = 20) for 4 weeks;Negative Control Group: After the normal diet of 4 weeks, the group was given normal diet (n = 20) for 6 weeks; Low-dose group: After the HFD of 4 weeks, the group was administered TFSC orally once a day at a low dose of 100 mg/kg (n = 20) for 6 weeks; Middle-dose group: After the HFD of 4 weeks, the group was administered TFSC orally once a day at a medium dose of 200 mg/kg (n = 20) for 6 weeks; High-dose group: After the HFD of 4 weeks, the group was administered TFSC orally once a day at a high dose of 400 mg/kg (n = 20) for 6 weeks; Positive control group: After the HFD of 4 weeks, the group was given high-fat diet (n = 20) for 6 weeks