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Table 3 Effect of total flavonoids in Stellera chamaejasme L. on serum lipid level in rats (mean ± SD) (n = 20)

From: Prevention and treatment effect of total flavonoids in Stellera chamaejasme L. on nonalcoholic fatty liver in rats

Parameter 4w 6w
Normal group NAFLD group Normal group Low-dose group Middle-dose group High-dose group Positive control group
AST (U/L) 75.17 ± 4.31 96.85 ± 7.63 76.29 ± 5.16 97.36 ± 6.82** 93.75 ± 4.55* 88.34 ± 6.27*# 101.67 ± 8.36
ALT(U/L) 28.16 ± 1.21 51.28 ± 3.26 29.25 ± 1.72 53.28 ± 4.41** 49.78 ± 2.19** 44.29 ± 2.22**# 56.35 ± 4.16
TG(mmol/L) 0.59 ± 0.09 1.65 ± 0.08 0.61 ± 0.04 1.81 ± 0.11** 1.46 ± 0.09**# 0.92 ± 0.03**## 2.12 ± 0.12
TC(mmol/L) 1.66 ± 0.12 3.14 ± 0.13 1.70 ± 0.09 3.82 ± 0.15** 3.65 ± 0.17**# 2.65 ± 0.12**## 4.54 ± 0.24
LDL-C (mmol/L) 0.54 ± 0.03 1.25 ± 0.08 0.56 ± 0.04 1.37 ± 0.08** 1.24 ± 0.05** 1.09 ± 0.06**# 1.35 ± 0.09
HDL-C (mmol/L) 0.96 ± 0.04 0.64 ± 0.04 0.98 ± 0.05 0.64 ± 0.03** 0.69 ± 0.05** 0.77 ± 0.04*# 0.55 ± 0.03
GLU (mmol/L) 4.68 ± 0.15 5.07 ± 0.21 4.56 ± 0.18 4.99 ± 0.87 5.07 ± 0.04 5.13 ± 18.88 5.41 ± 0.19
TBA(μmol/L) 6.75 ± 0.05 10.23 ± 0.06 6.54 ± 0.06 11.53 ± 1.27** 11.04 ± 0.98** 10.24 ± 0.05**# 12.27 ± 1.25
Leptin (μg/L) 0.18 ± 0.01 0.32 ± 0.01 0.19 ± 0.02 0.46 ± 0.03** 0.34 ± 0.02*# 0.28 ± 0.01# 0.46 ± 0.03
SOD (U/mL) 374.36 ± 17.86 300.4 ± 20.1 370.35 ± 19.46 293.4 ± 24.1** 321.79 ± 23.16* 348.32 ± 19.76# 297.84 ± 23.17
MDA (nmol/mL) 3.26 ± 0.21 4.27 ± 0.16 3.25 ± 0.75 4.98 ± 1.32* 4.77 ± 0.87* 3.84 ± 0.99## 5.04 ± 1.27
GSH-Px (U/mL) 256.21 ± 19.25 210.45 ± 14.2 255.98 ± 20.54 206.88 ± 15.3** 211.57 ± 17.45**# 238.78 ± 14.25# 194.21 ± 17.35
  1. P < 0.05, P < 0.01, compared to normal control group (4w). *P < 0.05, **P < 0.01, compared to normal group (6w); # P < 0.05, ## P < 0.01, compared to positive control group (6w). Normal Group: the group was given normal diet (n = 20) for 4 weeks; NAFLD Group: the group was given high-fat diet (n = 20) for 4 weeks;Negative Control Group: After the normal diet of 4 weeks, the group was given normal diet (n = 20) for 6 weeks; Low-dose group: After the HFD of 4 weeks, the group was administered TFSC orally once a day at a low dose of 100 mg/kg (n = 20) for 6 weeks; Middle-dose group: After the HFD of 4 weeks, the group was administered TFSC orally once a day at a medium dose of 200 mg/kg (n = 20) for 6 weeks; High-dose group: After the HFD of 4 weeks, the group was administered TFSC orally once a day at a high dose of 400 mg/kg (n = 20) for 6 weeks; Positive control group: After the HFD of 4 weeks, the group was given high-fat diet (n = 20) for 6 weeks