LDL in patients with subclinical hypothyroidism shows increased lipid peroxidation

Table 1 Clinical and laboratory data of the studied groups

Variable	Euthyroid	Mild SCH	Significant SCH	p ^a	p ^b	p ^c
n	10	10	10	NA	NA	NA
Gender (male/female)	4/6	3/7	2/8		0.879
Age (years)	52.0 ± 5.7	53.2 ± 5.4	57.3 ± 5.5	1.000	0.125	0.329
BMI (kg/m²)	24.0 ± 1.6	24.4 ± 1.8	24.4 ± 1.5	1.000	1.000	1.000
SBP (mmHg)	130.0 ± 17.8	129.6 ± 12.4	126.4 ± 21.5	1.000	1.000	1.000
DBP (mmHg)	77.1 ± 8.5	80.4 ± 6.8	75.3 ± 5.6	0.915	1.000	0.353
Mean-IMT (mm)	0.75 ± 0.09	0.82 ± 0.14	0.99 ± 0.32	1.000	0.045	0.193
FBG (mmol/l)	5.41 ± 0.63	5.72 ± 0.65	5.34 ± 0.31	0.477	0.946	0.202
FT3 (pmol/L)	4.79 ± 0.39	5.23 ± 0.77	4.89 ± 0.41	0.210	0.825	0.376
FT4 (pmol/L)	14.33 ± 1.42	14.55 ± 1.59	13.79 ± 1.47	1.000	1.000	0.652
TSH (mIU/L)	3.32 ± 0.57	5.92 ± 1.47	12.98 ± 3.23	0.013	0.000	0.000
TC (mmol/l)	5.15 ± 0.43	5.75 ± 1.00	5.81 ± 1.13	0.117	0.183	0.990
HDL-C (mmol/l)	1.45 ± 0.15	1.50 ± 0.36	1.61 ± 0.42	0.896	0.429	0.762
LDL-C (mmol/l)	2.78 ± 0.35	3.16 ± 0.61	3.43 ± 0.59	0.372	0.032	0.779
TG (mmol/l)	0.92 ± 0.07	1.16 ± 0.27	1.15 ± 0.31	0.117	0.142	1.000

Continuous and categorical variables data are expressed as the mean ± standard deviations and real number of subjects, respectively. The statistical p value was generated by one-way ANOVA with Bonferroni correction as the post-hoc test. The χ-square test was employed to compare gender distribution. P ^arepresents the mild SCH vs euthyroid group, P ^brepresents the significant SCH vs euthyroid group, and P ^crepresents the significant SCH vs mild SCH group. Abbreviation: mild SH, mild subclinical hypothyroidism group; significant SCH, significant subclinical hypothyroidism group; BMI body mass index, mean-IMT mean carotid intima-media thickness, FBG fasting blood glucose, FT3 free T3, FT4 free T4, TSH thyroid stimulating hormone, TC total cholesterol, HDL-C high-density lipoprotein, LDL-C low-density lipoprotein, TG triglyceride, NA not applicable

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