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Table 1 Characteristics of the included studies

From: Efficacy of high-dose rosuvastatin preloading in patients undergoing percutaneous coronary intervention: a meta-analysis of fourteen randomized controlled trials

Study Patients (RSV/ Con) Type of population Clinical feature Timing before PCI Regimen after PCI Follow-up Definition of PMI
Gao [19] 59/58 Statin naïve NSTE-ACS RSV 20 mg 12 h and 10 mg 2 h before PCI VS placebo treatment RSV 10 mg/d for at least 1 year 6 months CKMB > 3 UNL
Li [18] 103/ 100 Statin naïve STEMI RSV 20 mg before PCI VS RSV 10 mg treatment RSV 10 mg/d for 3 months 30 days CKMB > 3 UNL
Luo [17] 31/36 Statin naïve NSTE-ACS RSV 20 mg 12 h and 20 mg 2 h before PCI VS no statin pretreatment RSV 10 mg/d 30 days cTnI > 3 UNL
Takano [14] 104/ 106 Mixed Stable Angina RSV 20 mg 5-7day before PCI VS RSV 2.5 mg treatment RSV 10 mg/d VS RSV 2.5 mg/d 12 months CKMB > 3 UNL
Wang [13] 62/63 Statin naïve NSTE-ACS RSV 20 mg before PCI VS placebo pretreatment RSV 10 mg/d for at least 30 days 30 days CKMB > 3 UNL
Xie [8] 79/80 Statin naïve NSTE-ACS RSV 20 mg 12 h and 20 mg 2 h before PCI VS placebo treatment RSV 10 mg/d 30 days cTnI > 5 UNL
Yun [20] 225/ 220 Statin naïve NSTE-ACS RSV 40 mg before PCI VS no statin pretreament RSV 10 mg/d 12 months CKMB > 2 UNL
Veselka [9] 220/ 225 Mixed Stable Angina RSV 20 mg 12 h and 20 mg before PCI VS no statin pretreatment Statin treatment In hospital cTnI > 5 UNL
Cay [21] 153/ 146 Statin naïve Stable Angina RSV 40 mg 24 h before PCI VS no RSV pretreatment RSV 10-40 mg/d In hospital CKMB > 3 UNL
Leoncini [11] 252/ 252 Statin naïve NSTE-ACS RSV 40 mg 24 h and 20 mg before PCI VS no statin pretreatment RSV 20 mg/d VS atorvastatin 40 mg/d 6 months CKMB > 3 UNL
ROMA [16] 80/80 Statin naïve Stable Angina RSV 40 mg 24 h before PCI VS no RSV pretreatment RSV 20 mg/d 12 months CKMB > 3 UUNL
ROMAII [15] 175/ 100 prior statin treatment Stable Angina RSV 40 mg 24 h before PCI VS no statin pretreatment RSV 20 mg/d 12 months CKMB > 3 UNL
Ko [12] 62/70 Mixed STEMI RSV 40 mg before PCI VS placebo treatment RSV 40 mg VS 10 mg both for 7 days, and a further 10 mg/d in both groups for 3 weeks 3 months NA
Liang [10] 66/66 Statin naïve ACS RSV 40 mg 4 h VS RSV 10 mg before PCI RSV 10 mg/d for at least 1 year 6 months NA
  1. RSV rosuvastatin, CK-MB creatine kinase-myocardial band, cTnI cardiac troponin I, UNL upper normal limit, Mixed Statin naïve and prior statin treatment, PMI periprocedural myocardial infarction, ACS acute coronary syndrome, NSTE-ACS non-ST segment elevation ACS, STEMI ST segment elevation myocardial infarction, NA not available