A comparative study between Wuweizi seed and its post-ethanol extraction residue in normal and hypercholesterolemic mice

Chu, Zhu-Sheng; Yu, Zhi-Ling; Pan, Si-Yuan; Jia, Zhan-Hong; Wang, Xiao-Yan; Zhang, Yi; Zhu, Pei-Li; Wang, Xiu-Juan; Ko, Kam-Ming

doi:10.1186/s12944-015-0097-z

Lipids in Health and Disease

Table 4 Effects of FSC-S and FSC-SpEt supplementation on organ/tissue mass in normal and experimental hypercholesterolemic (HCL) mice

From: A comparative study between Wuweizi seed and its post-ethanol extraction residue in normal and hypercholesterolemic mice

Groups	Drug dose (%, w/w)	Weight (g)				Index 1				Index 2
Groups	Drug dose (%, w/w)	Fat	Kindey	Spleen	Testis	Fat	Kindey	Spleen	Testis	Fat	Kindey	Spleen	Testis
Normal mice
ND	–	0.25 ± 0.02	0.45 ± 0.02	0.14 ± 0.01	0.17 ± 0.01	0.90 ± 0.06	1.59 ± 0.06	0.51 ± 0.03	0.59 ± 0.04	0.96 ± 0.06	1.69 ± 0.06	0.54 ± 0.03	0.62 ± 0.04
ND/FSC-S	9	0.04 ± 0.01^**	0.25 ± 0.01^**	0.07 ± 0.01^**	0.16 ± 0.01	0.19 ± 0.02^**	1.22 ± 0.03^**	0.36 ± 0.02^**	0.78 ± 0.04^**	0.21 ± 0.02^**	1.35 ± 0.04^**	0.39 ± 0.02^**	0.86 ± 0.04^**
ND/FSC-SpEt	9	0.24 ± 0.01	0.47 ± 0.01	0.13 ± 0.01	0.19 ± 0.01	0.83 ± 0.04	1.67 ± 0.03	0.45 ± 0.01	0.66 ± 0.02	0.89 ± 0.04	1.79 ± 0.03	0.49 ± 0.02	0.70 ± 0.02
ND/FF	0.05	0.12 ± 0.01^**	0.44 ± 0.02	0.12 ± 0.01^*	0.18 ± 0.01	0.45 ± 0.05^**	1.59 ± 0.04	0.45 ± 0.02	0.66 ± 0.03	0.50 ± 0.05^**	1.76 ± 0.05	0.50 ± 0.03	0.74 ± 0.03^*
HCL mice
ND	–	0.32 ± 0.02	0.48 ± 0.02	0.15 ± 0.01	0.20 ± 0.01	1.10 ± 0.05	1.65 ± 0.43	0.50 ± 0.02	0.69 ± 0.03	1.17 ± 0.05	1.76 ± 0.05	0.53 ± 0.02	0.74 ± 0.03
HCBD	–	0.23 ± 0.02^**	0.48 ± 0.01	0.14 ± 0.01	0.20 ± 0.01	0.79 ± 0.06^**	1.64 ± 0.04	0.50 ± 0.03	0.69 ± 0.03	0.85 ± 0.07^**	1.77 ± 0.04	0.53 ± 0.03	0.74 ± 0.04
HCBD/FSC-S	3	0.26 ± 0.02	0.46 ± 0.02	0.15 ± 0.01	0.20 ± 0.01	0.88 ± 0.07	1.58 ± 0.05	0.51 ± 0.04	0.68 ± 0.02	0.97 ± 0.08	1.73 ± 0.05	0.56 ± 0.42	0.75 ± 0.02
	9	0.13 ± 0.02^##	0.35 ± 0.01^##	0.11 ± 0.01^##	0.18 ± 0.01	0.49 ± 0.07^##	1.39 ± 0.03^##	0.44 ± 0.02	0.71 ± 0.04	0.56 ± 0.08^#	1.57 ± 0.03^##	0.49 ± 0.03	0.80 ± 0.05
HCBD/FSC-SpEt	3	0.21 ± 0.02	0.48 ± 0.02	0.14 ± 0.01	0.19 ± 0.01	0.71 ± 0.06	1.68 ± 0.06	0.50 ± 0.02	0.67 ± 0.03	0.77 ± 0.06	1.81 ± 0.07	0.53 ± 0.02	0.72 ± 0.04
	9	0.20 ± 0.02	0.48 ± 0.02	0.12 ± 0.01	0.20 ± 0.01	0.70 ± 0.06	1.70 ± 0.04	0.43 ± 0.02	0.70 ± 0.03	0.76 ± 0.07	1.84 ± 0.05	0.46 ± 0.03	0.75 ± 0.04
HCBD/FF	0.05	0.13 ± 0.01^##	0.51 ± 0.20	0.12 ± 0.01^#	0.20 ± 0.01	0.45 ± 0.02^##	1.79 ± 0.07	0.41 ± 0.03^#	0.71 ± 0.02	0.51 ± 0.02^##	2.03 ± 0.08^##	0.47 ± 0.03	0.80 ± 0.02

Experimental details were described in Table 1. Mice were fed with ND and HCBD without or with FSC-S, FSC-SpEt, or FF supplementation. Ten days after supplementation, epididymis fat, kidney, spleen and testis mass and index were measured. Index 1 and index 2 were estimated from the ratio of their weight to body weight × 100 or their weight to body weight – liver weight × 100, respectively. Values given are the means ± SEM, with n = 10. ^* P < 0.05, ^** P < 0.01 vs ND; ^# P < 0.05, ^## P < 0.01 vs HCBD. Statistical significant differences were determined using a one-way ANOVA followed by Dunnett’s multiple comparisons test or post-hoc analysis

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