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Table 4 Effects of FSC-S and FSC-SpEt supplementation on organ/tissue mass in normal and experimental hypercholesterolemic (HCL) mice

From: A comparative study between Wuweizi seed and its post-ethanol extraction residue in normal and hypercholesterolemic mice

Groups Drug dose (%, w/w) Weight (g) Index 1 Index 2
Fat Kindey Spleen Testis Fat Kindey Spleen Testis Fat Kindey Spleen Testis
Normal mice              
ND 0.25 ± 0.02 0.45 ± 0.02 0.14 ± 0.01 0.17 ± 0.01 0.90 ± 0.06 1.59 ± 0.06 0.51 ± 0.03 0.59 ± 0.04 0.96 ± 0.06 1.69 ± 0.06 0.54 ± 0.03 0.62 ± 0.04
ND/FSC-S 9 0.04 ± 0.01** 0.25 ± 0.01** 0.07 ± 0.01** 0.16 ± 0.01 0.19 ± 0.02** 1.22 ± 0.03** 0.36 ± 0.02** 0.78 ± 0.04** 0.21 ± 0.02** 1.35 ± 0.04** 0.39 ± 0.02** 0.86 ± 0.04**
ND/FSC-SpEt 9 0.24 ± 0.01 0.47 ± 0.01 0.13 ± 0.01 0.19 ± 0.01 0.83 ± 0.04 1.67 ± 0.03 0.45 ± 0.01 0.66 ± 0.02 0.89 ± 0.04 1.79 ± 0.03 0.49 ± 0.02 0.70 ± 0.02
ND/FF 0.05 0.12 ± 0.01** 0.44 ± 0.02 0.12 ± 0.01* 0.18 ± 0.01 0.45 ± 0.05** 1.59 ± 0.04 0.45 ± 0.02 0.66 ± 0.03 0.50 ± 0.05** 1.76 ± 0.05 0.50 ± 0.03 0.74 ± 0.03*
HCL mice              
ND 0.32 ± 0.02 0.48 ± 0.02 0.15 ± 0.01 0.20 ± 0.01 1.10 ± 0.05 1.65 ± 0.43 0.50 ± 0.02 0.69 ± 0.03 1.17 ± 0.05 1.76 ± 0.05 0.53 ± 0.02 0.74 ± 0.03
HCBD 0.23 ± 0.02** 0.48 ± 0.01 0.14 ± 0.01 0.20 ± 0.01 0.79 ± 0.06** 1.64 ± 0.04 0.50 ± 0.03 0.69 ± 0.03 0.85 ± 0.07** 1.77 ± 0.04 0.53 ± 0.03 0.74 ± 0.04
HCBD/FSC-S 3 0.26 ± 0.02 0.46 ± 0.02 0.15 ± 0.01 0.20 ± 0.01 0.88 ± 0.07 1.58 ± 0.05 0.51 ± 0.04 0.68 ± 0.02 0.97 ± 0.08 1.73 ± 0.05 0.56 ± 0.42 0.75 ± 0.02
  9 0.13 ± 0.02## 0.35 ± 0.01## 0.11 ± 0.01## 0.18 ± 0.01 0.49 ± 0.07## 1.39 ± 0.03## 0.44 ± 0.02 0.71 ± 0.04 0.56 ± 0.08# 1.57 ± 0.03## 0.49 ± 0.03 0.80 ± 0.05
HCBD/FSC-SpEt 3 0.21 ± 0.02 0.48 ± 0.02 0.14 ± 0.01 0.19 ± 0.01 0.71 ± 0.06 1.68 ± 0.06 0.50 ± 0.02 0.67 ± 0.03 0.77 ± 0.06 1.81 ± 0.07 0.53 ± 0.02 0.72 ± 0.04
  9 0.20 ± 0.02 0.48 ± 0.02 0.12 ± 0.01 0.20 ± 0.01 0.70 ± 0.06 1.70 ± 0.04 0.43 ± 0.02 0.70 ± 0.03 0.76 ± 0.07 1.84 ± 0.05 0.46 ± 0.03 0.75 ± 0.04
HCBD/FF 0.05 0.13 ± 0.01## 0.51 ± 0.20 0.12 ± 0.01# 0.20 ± 0.01 0.45 ± 0.02## 1.79 ± 0.07 0.41 ± 0.03# 0.71 ± 0.02 0.51 ± 0.02## 2.03 ± 0.08## 0.47 ± 0.03 0.80 ± 0.02
  1. Experimental details were described in Table 1. Mice were fed with ND and HCBD without or with FSC-S, FSC-SpEt, or FF supplementation. Ten days after supplementation, epididymis fat, kidney, spleen and testis mass and index were measured. Index 1 and index 2 were estimated from the ratio of their weight to body weight × 100 or their weight to body weight – liver weight × 100, respectively. Values given are the means ± SEM, with n = 10. * P < 0.05, ** P < 0.01 vs ND; # P < 0.05, ## P < 0.01 vs HCBD. Statistical significant differences were determined using a one-way ANOVA followed by Dunnett’s multiple comparisons test or post-hoc analysis