Skip to main content

Table 5 Associations of genotypes and serum lipid profiles

From: Joint associations of folate, homocysteine and MTHFR, MTR and MTRR gene polymorphisms with dyslipidemia in a Chinese hypertensive population: a cross-sectional study

Genotype TC TAG
Mean ± SD β (SE)a Pb Mean ± SD β (SE)a Pb
MTHFR C677T       
 CC 5.01 ± 1.42 Reference   1.75 ± 1.06 Reference  
 CT 4.94 ± 0.98 -0.05 (0.13) 0.337 1.75 ± 1.19 -0.01 (0.13) 0.799
 TT 5.12 ± 1.00 0.02 (0.08) 0.811 1.69 ± 1.49 -0.03 (0.08) 0.701
MTHFR A1298C       
 AA 4.97 ± 0.98 Reference   1.69 ± 1.15 Reference  
 AC 5.10 ± 1.45 0.05 (0.12) 0.263 1.89 ± 1.48 0.06 (0.13) 0.231
 CC 4.94 ± 0.83 0.01 (0.12) 0.846 1.56 ± 0.94 -0.03 (0.15) 0.633
MTR A2756G       
 AA 5.02 ± 1.11 Reference   1.76 ± 1.30 Reference  
 AG 4.92 ± 1.09 -0.00 (0.14) 0.966 1.62 ± 0.93 -0.02 (0.15) 0.698
 GG 5.18 ± 2.23 0.02 (0.28) 0.714 1.73 ± 0.40 -0.02 (0.31) 0.703
MTRR A66G       
 AA 4.82 ± 0.99 Reference   1.71 ± 1.25 Reference  
 AG 5.03 ± 0.95 0.09 (0.10) 0.091 1.77 ± 1.30 -0.01 (0.13) 0.853
 GG 5.27 ± 1.64 0.14 (0.09) 0.054 1.70 ± 1.03 -0.02 (0.08) 0.757
Genotype HDL-C LDL-C
Mean ± SD β (SE)a Pb Mean ± SD β (SE)a Pb
MTHFR C677T       
 CC 1.33 ± 0.36 Reference   2.87 ± 0.83 Reference  
 CT 1.28 ± 0.35 -0.08 (0.04) 0.111 2.91 ± 0.80 0.01 (0.10) 0.801
 TT 1.34 ± 0.39 -0.01 (0.02) 0.904 2.97 ± 0.74 0.04 (0.05) 0.550
MTHFR A1298C       
 AA 1.30 ± 0.36 Reference   2.93 ± 0.77 Reference  
 AC 1.31 ± 0.36 0.02 (0.04) 0.689 2.89 ± 0.84 -0.02 (0.09) 0.707
 CC 1.39 ± 0.48 0.08 (0.05) 0.129 2.92 ± 0.82 0.00 (0.11) 0.993
MTR A2756G       
 AA 1.31 ± 0.37 Reference   2.91 ± 0.78 Reference  
 AG 1.28 ± 0.33 -0.02 (0.04) 0.658 2.91 ± 0.84 0.01 (0.10) 0.784
 GG 1.33 ± 0.42 0.04 (0.09) 0.456 3.39 ± 0.85 0.06 (0.20) 0.288
MTRR A66G       
 AA 1.27 ± 0.37 Reference   2.85 ± 0.79 Reference  
 AG 1.32 ± 0.35 0.06 (0.04) 0.223 2.94 ± 0.80 0.06 (0.09) 0.303
 GG 1.36 ± 0.37 0.07 (0.03) 0.274 2.98 ± 0.77 0.06 (0.06) 0.369
  1. TC total cholesterol, TAG triacylglycerols, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol
  2. aβ = regression coefficient
  3. bAdjusted for sex, age, clinical centers, height and weight