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Table 7 Interactions of genotypes and low folate with low levels of high-density lipoprotein cholesterol (HDL-C)

From: Joint associations of folate, homocysteine and MTHFR, MTR and MTRR gene polymorphisms with dyslipidemia in a Chinese hypertensive population: a cross-sectional study

Genotype Folate statusa Low HDL-Cb High HDL-Cb OR (95 % Cl) Pc Trend test Pc
MTHFR C677T  
 CC High FA 13 (13.8) 71 (21.5) Reference   0.12 (0.02) 0.008
 CT + TT High FA 45 (47.9) 177 (53.5) 1.82 (0.87-3.81) 0.114
 CC Low FA 7 (7.4) 17 (5.1) 1.13 (0.23-5.65) 0.883
 CT + TT Low FA 29 (30.9) 66 (19.9) 2.67 (1.08-6.60) 0.033
MTHFR A1298C  
 AA High FA 40 (42.6) 171 (51.7) Reference   0.10 (0.02) 0.031
 AC + CC High FA 18 (19.1) 77 (23.3) 0.94 (0.48-1.82) 0.842
 AA Low FA 24 (25.5) 64 (19.3) 1.59 (0.82-3.08) 0.172
 AC + CC Low FA 12 (12.8) 19 (5.7) 2.52 (0.97-6.57) 0.059
MTR A2756G  
 AA High FA 51 (54.3) 205 (61.9) Reference   0.08 (0.02) 0.099
 AG + GG High FA 7 (7.4) 43 (13.0) 0.53 (0.21-1.32) 0.173
 AA Low FA 27 (28.7) 65 (19.6) 1.66 (0.88-3.13) 0.116
 AG + GG Low FA 9 (9.6) 18 (5.4) 1.73 (0.66-4.52) 0.263
MTRR A66G  
 AA High FA 17 (18.1) 85 (25.7) Reference   0.07 (0.02) 0.142
 AG + GG High FA 41 (43.6) 163 (49.2) 1.28 (0.66-2.49) 0.468
 AA Low FA 19 (20.2) 16 (4.8) 4.66 (1.67-13.06) 0.003
 AG + GG Low FA 17 (18.1) 67 (20.2) 1.52 (0.59-3.92) 0.382
  1. aHigh FA: serum folate level ≥ 10 nmol/L, Low FA: serum folate level < 10 nmol/L
  2. bLow HDL-C: serum HDL-C < 1.04 mmol/L; High HDL-C: serum HDL-C ≥ 1.04 mmol/L
  3. cAdjusted for sex, age, clinical centers, height and weight