Table 7 Interactions of genotypes and low folate with low levels of high-density lipoprotein cholesterol (HDL-C)
Genotype | Folate statusa | Low HDL-Cb | High HDL-Cb | OR (95Â % Cl) | Pc | Trend test | Pc |
|---|---|---|---|---|---|---|---|
MTHFR C677T | Â | ||||||
 CC | High FA | 13 (13.8) | 71 (21.5) | Reference |  | 0.12 (0.02) | 0.008 |
 CT + TT | High FA | 45 (47.9) | 177 (53.5) | 1.82 (0.87-3.81) | 0.114 | ||
 CC | Low FA | 7 (7.4) | 17 (5.1) | 1.13 (0.23-5.65) | 0.883 | ||
 CT + TT | Low FA | 29 (30.9) | 66 (19.9) | 2.67 (1.08-6.60) | 0.033 | ||
MTHFR A1298C | Â | ||||||
 AA | High FA | 40 (42.6) | 171 (51.7) | Reference |  | 0.10 (0.02) | 0.031 |
 AC + CC | High FA | 18 (19.1) | 77 (23.3) | 0.94 (0.48-1.82) | 0.842 | ||
 AA | Low FA | 24 (25.5) | 64 (19.3) | 1.59 (0.82-3.08) | 0.172 | ||
 AC + CC | Low FA | 12 (12.8) | 19 (5.7) | 2.52 (0.97-6.57) | 0.059 | ||
MTR A2756G | Â | ||||||
 AA | High FA | 51 (54.3) | 205 (61.9) | Reference |  | 0.08 (0.02) | 0.099 |
 AG + GG | High FA | 7 (7.4) | 43 (13.0) | 0.53 (0.21-1.32) | 0.173 | ||
 AA | Low FA | 27 (28.7) | 65 (19.6) | 1.66 (0.88-3.13) | 0.116 | ||
 AG + GG | Low FA | 9 (9.6) | 18 (5.4) | 1.73 (0.66-4.52) | 0.263 | ||
MTRR A66G | Â | ||||||
 AA | High FA | 17 (18.1) | 85 (25.7) | Reference |  | 0.07 (0.02) | 0.142 |
 AG + GG | High FA | 41 (43.6) | 163 (49.2) | 1.28 (0.66-2.49) | 0.468 | ||
 AA | Low FA | 19 (20.2) | 16 (4.8) | 4.66 (1.67-13.06) | 0.003 | ||
 AG + GG | Low FA | 17 (18.1) | 67 (20.2) | 1.52 (0.59-3.92) | 0.382 | ||