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Table 2 Baseline and change in low-density lipoprotein particle size by end-of-treatment triglyceride category

From: Effects of omega-3 carboxylic acids on lipoprotein particles and other cardiovascular risk markers in high-risk statin-treated patients with residual hypertriglyceridemia: a randomized, controlled, double-blind trial

End-of-treatment TG category and

Statin + OO

Statin + OM3-CA

Statin + OM3-CA

LDL particle size

4 g/d

2 g/da

4 g/d

 

Mean (95 % CI)

TG <1.7 mmol/L (<150 mg/dL)

(n = 15)

(n = 14)

(n = 33)

  Baseline LDL particle size (nm)

20.33 (20.09, 20.57)

20.10 (19.89, 20.31)

20.17 (20.03, 20.31)

  Δ from baseline LDL particle size (nm)

0.22 (0.03, 0.41)

0.15 (0.00, 0.30)

0.31 (0.17, 0.45)

TG 1.7–2.2 mmol/L (150–199 mg/dL)

(n = 33)

(n = 52)

(n = 54)

  Baseline LDL particle size (nm)

20.12 (19.96, 20.28)

20.03 (19.95, 20.11)

20.05 (19.93, 20.17)

  Δ from baseline LDL particle size (nm)

0.09 (−0.03, 0.21)

0.10 (0.04, 0.16)

0.17 (0.09, 0.25)

TG ≥2.3 mmol/L (≥200 mg/dL)

(n = 163)

(n = 142)

(n = 120)

  Baseline LDL particle size (nm)

19.87 (19.82, 19.92)

19.89 (19.83, 19.95)

19.82 (19.77, 19.87)

  Δ from baseline LDL particle size (nm)

−0.05 (−0.09, −0.01)

0.05 (0.00, 0.10)

0.04 (0.00, 0.08)

  1. Abbreviations: ∆ change, CI confidence interval, LDL low-density lipoprotein, OM3-CA omega-3 carboxylic acids, OO olive oil, TG triglycerides
  2. aPatients in the OM3-CA 2 g/d treatment arm also received OO capsules at a dosage of 2 g/d