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Table 3 Genotype and allele distributions in patients with CAD and control subjects (Han Chinese)
| Total | Male | Female | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CAD n (%) | Control n (%) | P value | CAD n (%) | Control n (%) | P value | CAD n (%) | Control n (%) | P value | ||||
| rs12435797 | Genotype | T/T | 173(45.6) | 185(43.6) | 0.378 | 125(47.2) | 94(43.5) | 0.436 | 48(42.1) | 91(43.8) | 0.924 | |
| (SNP1) | G/G | 38(10.1) | 56(13.2) | 22(8.3) | 25(11.6) | 16(14.0) | 31(14.9) | |||||
| G/T | 168(44.3) | 183(43.2) | 118(44.5) | 97(44.9) | 50(43.9) | 86(41.3) | ||||||
| Dominant model | TT | 173(45.6) | 185(43.6) | 0.570 | 125(47.2) | 94(43.5) | 0.462 | 48(42.1) | 91(43.8) | 0.815 | ||
| GT + GG | 206(54.4) | 239(56.4) | 140(52.8) | 122(56.5) | 66(57.9) | 117(56.2) | ||||||
| Recessive model | GG | 38(10.1) | 56(13.2) | 0.187 | 22(8.3) | 25(11.6) | 0.280 | 16(14.0) | 31(14.9) | 0.871 | ||
| GT + TT | 341(89.9) | 368(86.8) | 243(91.7) | 191(88.4) | 98(86.0) | 177(85.1) | ||||||
| Additive model | GT | 168(44.3) | 183(43.20) | 0.776 | 118(44.5) | 97(44.9) | 1 | 50(43.9) | 86(41.3) | 0.724 | ||
| TT + GG | 211(55.7) | 241(56.80) | 147(55.5) | 119(55.1) | 64(56.1) | 122(58.7) | ||||||
| Allele | T | 514(67.75) | 553(65.20) | 0.290 | 368(69.45) | 285(65.95) | 0.267 | 146(64.05) | 268(64.45) | 0.932 | ||
| G | 244(32.25) | 295(34.80) | 162(30.55) | 147(34.05) | 82(35.95) | 148(35.55) | ||||||
| rs2108552 | Genotype | C/C | 112(29.2) | 88(20.5) | 0.013* | 79(29.3) | 36(16.4) | 0.003* | 33(28.9) | 52(24.8) | 0.724 | |
| (SNP2) | G/G | 85(22.1) | 116(27.1) | 58(21.5) | 62(28.3) | 27(23.7) | 54(25.7) | |||||
| C/G | 187(48.7) | 225(52.4) | 133(49.2) | 121(55.3) | 54(47.4) | 104(49.5) | ||||||
| Dominant model | CC | 112(29.2) | 88(20.5) | 0.004* | 79(29.3) | 36(16.4) | 0.001* | 33(28.9) | 52(24.8) | 0.430 | ||
| CG + GG | 272(70.8) | 341(79.5) | 191(70.7) | 183(83.6) | 81(71.1) | 158(75.2) | ||||||
| Recessive model | GG | 85(22.1) | 116(27.1) | 0.122 | 58(21.5) | 62(28.3) | 0.091 | 27(23.7) | 54(25.7) | 0.788 | ||
| CG + CC | 299(77.9) | 313(72.9) | 212(78.5) | 157(71.7) | 87(76.3) | 156(74.3) | ||||||
| Additive model | CG | 187(48.7) | 225(52.4) | 0.293 | 133(49.2) | 121(55.3) | 0.203 | 54(47.4) | 104(49.5) | 0.728 | ||
| CC + GG | 197(51.3) | 204(47.6) | 137(50.7) | 98(44.7) | 60(52.6) | 106(50.5) | ||||||
| Allele | C | 411(53.55) | 401(46.7) | 0.007* | 291(53.9) | 193(44.05) | 0.003* | 120(52.6) | 208(49.55) | 0.460 | ||
| G | 357(46.45) | 457(53.3) | 249(46.1) | 245(55.95) | 108(47.4) | 212(50.45) | ||||||
| rs1019075 | Genotype | C/C | 21(5.5) | 24(5.6) | 0.041* | 12(4.5) | 9(4.1) | 0.060 | 9(7.9) | 15(7.2) | 0.351 | |
| (SNP3) | T/T | 257(67.3) | 252(59.0) | 179(66.8) | 124(56.9) | 78(68.4) | 128(61.2) | |||||
| C/T | 104(27.2) | 151(35.4) | 77(28.7) | 83(39.0) | 27(23.7) | 66(31.6) | ||||||
| Dominant model | CC | 21(5.5) | 24(5.6) | 1 | 12(4.5) | 9(4.1) | 1 | 9(7.9) | 15(7.2) | 0.827 | ||
| CT + TT | 361(94.5) | 403(94.4) | 256(95.5) | 209(95.9) | 105(92.1) | 194(92.8) | ||||||
| Recessive model | TT | 257(67.3) | 252(59.0) | 0.016* | 179(66.8) | 124(56.9) | 0.030* | 78(68.4) | 128(61.2) | 0.226 | ||
| CT + CC | 125(32.7) | 175(41.0) | 89(33.2) | 94(43.1) | 36(31.6) | 81(38.8) | ||||||
| Additive model | CT | 104(27.2) | 151(35.4) | 0.015* | 77(28.7) | 83(39.0) | 0.020* | 27(23.7) | 66(31.6) | 0.158 | ||
| CC + TT | 278(72.9) | 276(64.6) | 191(71.3) | 133(61.0) | 87(76.3) | 143(68.4) | ||||||
| Allele | C | 146(19.1) | 199(23.3) | 0.045* | 101(18.85) | 101(23.6) | 0.081* | 45(19.75) | 96(23.0) | 0.371 | ||
| T | 618(80.9) | 655(76.7) | 435(81.15) | 341(76.4) | 183(80.25) | 322(77.0) | ||||||
| rs17781919 | Genotype | C/C | 384(100.0) | 429(99.89) | 1 | 270(100.0) | 220(100.0) | 1 | 114(100.0) | 209(99.5) | 1 | |
| (SNP4) | C/T | 0(0.0) | 1(0.2) | 0(0.0) | 0(0.0) | 0(0.0) | 1(0.5) | |||||
| Allele | C | 768(100.0) | 859(99.9) | 1 | 540(100.0) | 440(100.0) | 1 | 228(100.0) | 419(99.8) | 1 | ||
| T | 0(0.0) | 1(0.1) | 0(0.0) | 0(0.0) | 0(0.0) | 1(0.2) | ||||||
