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Table 3 Genotype and allele distributions in patients with CAD and control subjects (Han Chinese)

From: The association of cholesterol absorption gene Numb polymorphism with Coronary Artery Disease among Han Chinese and Uighur Chinese in Xinjiang, China

     Total Male Female
     CAD n (%) Control n (%) P value CAD n (%) Control n (%) P value CAD n (%) Control n (%) P value
rs12435797 Genotype   T/T 173(45.6) 185(43.6) 0.378 125(47.2) 94(43.5) 0.436 48(42.1) 91(43.8) 0.924
(SNP1)    G/G 38(10.1) 56(13.2)   22(8.3) 25(11.6)   16(14.0) 31(14.9)  
  G/T 168(44.3) 183(43.2)   118(44.5) 97(44.9)   50(43.9) 86(41.3)  
   Dominant model TT 173(45.6) 185(43.6) 0.570 125(47.2) 94(43.5) 0.462 48(42.1) 91(43.8) 0.815
    GT + GG 206(54.4) 239(56.4)   140(52.8) 122(56.5)   66(57.9) 117(56.2)  
   Recessive model GG 38(10.1) 56(13.2) 0.187 22(8.3) 25(11.6) 0.280 16(14.0) 31(14.9) 0.871
    GT + TT 341(89.9) 368(86.8)   243(91.7) 191(88.4)   98(86.0) 177(85.1)  
   Additive model GT 168(44.3) 183(43.20) 0.776 118(44.5) 97(44.9) 1 50(43.9) 86(41.3) 0.724
    TT + GG 211(55.7) 241(56.80)   147(55.5) 119(55.1)   64(56.1) 122(58.7)  
  Allele   T 514(67.75) 553(65.20) 0.290 368(69.45) 285(65.95) 0.267 146(64.05) 268(64.45) 0.932
    G 244(32.25) 295(34.80)   162(30.55) 147(34.05)   82(35.95) 148(35.55)  
rs2108552 Genotype   C/C 112(29.2) 88(20.5) 0.013* 79(29.3) 36(16.4) 0.003* 33(28.9) 52(24.8) 0.724
(SNP2)    G/G 85(22.1) 116(27.1)   58(21.5) 62(28.3)   27(23.7) 54(25.7)  
    C/G 187(48.7) 225(52.4)   133(49.2) 121(55.3)   54(47.4) 104(49.5)  
   Dominant model CC 112(29.2) 88(20.5) 0.004* 79(29.3) 36(16.4) 0.001* 33(28.9) 52(24.8) 0.430
    CG + GG 272(70.8) 341(79.5)   191(70.7) 183(83.6)   81(71.1) 158(75.2)  
   Recessive model GG 85(22.1) 116(27.1) 0.122 58(21.5) 62(28.3) 0.091 27(23.7) 54(25.7) 0.788
    CG + CC 299(77.9) 313(72.9)   212(78.5) 157(71.7)   87(76.3) 156(74.3)  
   Additive model CG 187(48.7) 225(52.4) 0.293 133(49.2) 121(55.3) 0.203 54(47.4) 104(49.5) 0.728
    CC + GG 197(51.3) 204(47.6)   137(50.7) 98(44.7)   60(52.6) 106(50.5)  
  Allele   C 411(53.55) 401(46.7) 0.007* 291(53.9) 193(44.05) 0.003* 120(52.6) 208(49.55) 0.460
    G 357(46.45) 457(53.3)   249(46.1) 245(55.95)   108(47.4) 212(50.45)  
rs1019075 Genotype   C/C 21(5.5) 24(5.6) 0.041* 12(4.5) 9(4.1) 0.060 9(7.9) 15(7.2) 0.351
(SNP3)    T/T 257(67.3) 252(59.0)   179(66.8) 124(56.9)   78(68.4) 128(61.2)  
    C/T 104(27.2) 151(35.4)   77(28.7) 83(39.0)   27(23.7) 66(31.6)  
   Dominant model CC 21(5.5) 24(5.6) 1 12(4.5) 9(4.1) 1 9(7.9) 15(7.2) 0.827
    CT + TT 361(94.5) 403(94.4)   256(95.5) 209(95.9)   105(92.1) 194(92.8)  
   Recessive model TT 257(67.3) 252(59.0) 0.016* 179(66.8) 124(56.9) 0.030* 78(68.4) 128(61.2) 0.226
    CT + CC 125(32.7) 175(41.0)   89(33.2) 94(43.1)   36(31.6) 81(38.8)  
   Additive model CT 104(27.2) 151(35.4) 0.015* 77(28.7) 83(39.0) 0.020* 27(23.7) 66(31.6) 0.158
    CC + TT 278(72.9) 276(64.6)   191(71.3) 133(61.0)   87(76.3) 143(68.4)  
  Allele   C 146(19.1) 199(23.3) 0.045* 101(18.85) 101(23.6) 0.081* 45(19.75) 96(23.0) 0.371
    T 618(80.9) 655(76.7)   435(81.15) 341(76.4)   183(80.25) 322(77.0)  
rs17781919 Genotype   C/C 384(100.0) 429(99.89) 1 270(100.0) 220(100.0) 1 114(100.0) 209(99.5) 1
(SNP4)    C/T 0(0.0) 1(0.2)   0(0.0) 0(0.0)   0(0.0) 1(0.5)  
  Allele   C 768(100.0) 859(99.9) 1 540(100.0) 440(100.0) 1 228(100.0) 419(99.8) 1
    T 0(0.0) 1(0.1)   0(0.0) 0(0.0)   0(0.0) 1(0.2)  
  1. CAD coronary artery disease. The P value of genotype was calculated by Fisher’s exact test. * P <0.05
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Lipids in Health and Disease

ISSN: 1476-511X