Skip to main content

Advertisement

Table 4 Genotype and allele distributions in patients with CAD and control subjects (Uighur Chinese)

From: The association of cholesterol absorption gene Numb polymorphism with Coronary Artery Disease among Han Chinese and Uighur Chinese in Xinjiang, China

     Total Male Female
     CAD n (%) Control n (%) P value CAD n (%) Control n (%) P value CAD n (%) Control n (%) P value
rs12435797 (SNP1) Genotype   T/T 92(18.8) 72(20.6) 0.052 70(19.6) 45(21.2) 0.062 22(16.7) 27(19.6) 0.479
   G/G 135(27.6) 119(34.0)   101(28.2) 77(36.3)   34(25.8) 42(30.4)  
    G/T 263(53.6) 159(45.4)   187(52.2) 90(42.5)   76(57.6) 69(50.0)  
   Dominant model TT 92(18.8) 72(20.6) 0.537 70(19.6) 45(21.2) 0.438 22(16.7) 27(19.6) 1
    GT + GG 398(81.2) 278(79.4)   288(81.4) 167(78.8)   110(83.3) 111(80.4)  
   Recessive model GG 135(27.6) 119(34.0) 0.048* 101(28.2) 77(36.3) 0.034* 34(25.8) 42(30.4) 0.371
    GT + TT 355(72.4) 231(66.0)   257(71.8) 135(63.7)   98(74.2) 96(69.6)  
   Additive model GT 263(53.6) 159(45.4) 0.021* 187(52.2) 90(42.5) 0.009* 76(57.6) 69(50.0) 0.357
    TT + GG 227(46.4) 191(55.6)   171(47.8) 112(57.5)   56(42.4) 69(50.0)  
  Allele   T 447(45.6) 303(43.3) 0.370 334(45.7) 180(42.45) 0.340 120(45.5) 123(44.6) 0.623
    G 533(54.3) 397(56.7)   389(54.3) 244(57.55)   144(54.5) 153(55.4)  
rs2108552 Genotype   C/C 50(10.2) 31(8.8) 0.556 40(11.2) 20(9.4) 0.596 10(7.5) 11(8.0) 0.613
(SNP2)    G/G 209(42.5) 159(45.6)   154(43.0) 95(44.8)   55(41.0) 64(46.7)  
    C/G 233(47.4) 159(45.6)   164(45.8) 97(45.8)   69(51.5) 62(45.3)  
   Dominant model CC 50(10.2) 31(8.8) 0.628 40(11.2) 20(9.4) 0.466 10(7.5) 11(8.0) 1
    CG + GG 442(89.8) 318(91.2)   318(88.8) 182(91.6)   114(92.5) 126(92.0)  
   Recessive model GG 209(42.5) 159(45.6) 0.357 154(43.0) 95(44.8) 0.347 55(41.0) 64(46.7) 0.926
    CG + CC 283(57.5) 190(54.4)   204(57.0) 117(55.2)   79(59.0) 73(53.3)  
   Additive model CG 233(47.4) 159(45.6) 0.349 164(45.8) 97(45.8) 0.470 69(51.5) 62(45.3) 0.565
    CC + GG 259(52.6) 190(54.4)   194(54.2) 115(54.2)   66(48.5) 75(54.7)  
  Allele   C 333(33.9) 221(31.6) 0.606 244(34.1) 137(32.3) 0.347 89(33.25) 84(30.65) 0.565
    G 651(66.1) 477(68.4)   472(65.9) 287(67.7)   179(66.75) 190(59.35)  
rs1019075 Genotype   C/T 223(45.3) 148(42.5) 0.397 153(42.5) 91(43.1) 0.772 70(53.0) 57(41.6) 0.097
    C/C 66(13.4) 58(16.7)   53(14.7) 35(16.6)   13(9.8) 23(16.8)  
(SNP3)    T/T 203(41.3) 142(40.8)   154(42.8) 85(40.3)   49(37.1) 57(41.6)  
   Dominant model C/T 223(45.3) 148(42.5)   153(42.5) 91(43.1)   70(53.0) 57(41.6)  
    CC 66(13.4) 58(16.7) 0.191 53(14.7) 35(16.6) 0.460 13(9.8) 23(16.8) 0.098
    CT + TT 426(86.4) 290(83.3)   307(85.3) 176(83.4)   119(90.2) 114(83.2)  
   Recessive model TT 203(41.3) 142(40.8) 0.895 154(42.8) 85(40.3) 0.587 49(37.1) 57(41.6) 0.724
    CT + CC 289(58.7) 206(59.2)   206(57.2) 126(59.7)   83(62.9) 80(58.4)  
   Additive model CT 223(45.3) 148(42.5) 0.421 153(42.5) 91(43.1) 1 70(53.0) 57(41.6) 0.132
    CC + TT 269(55.7) 200(57.5)   207(57.5) 161(56.9)   62(47.0) 80(58.4)  
  Allele   C 355(36.05) 264(37.95) 0.438 259(35.95) 261(38.15) 0.394 96(37.3) 103(37.6) 0.612
    T 629(63.95) 432(62.05)   461(64.15) 232(61.85)   168(62.7) 171(62.4)  
rs17781919 Genotype   C/C 476(96.9) 338(96.8) 1 347(96.7) 202(95.7) 0.647 129(97.7) 136(98.6) 0.678
(SNP4)    C/T 15(3.1) 11(3.2)   12(3.3) 9(4.3)   3(2.3) 2(1.4)  
  Allele   C 967(98.45) 687(98.40) 1 706(98.35) 413(97.85) 1 261(98.85) 274(99.3) 0.467
    T 15(1.55) 11(1.60)   12(1.65) 9(2.15)   3(1.15) 2(0.7)  
  1. CAD coronary artery disease. The P value of genotype was calculated by Fisher’s exact test. * P <0.05.