Table 6 Haplotype analysis in patients with CAD and control subjects (Han Chinese)
Total(n = 817) | Male(n = 490) | Female(n = 327) | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Case(freq) | Control(freq) | χ2 | P value | Odds ratio(95 % CI) | Case(freq) | Control(freq) | χ2 | P value | Odds ratio(95 % CI) | Case(freq) | Control(freq) | χ2 | P value | Odds ratio(95 % CI) | |||
1 | 0100 | G G C C | 134.72(0.176) | 183.90(0.209) | 3.375 | 0.066 | 0.793(0.619–1.016) | 91.93(0.173) | 94.94(0.214) | 2.500 | 0.114 | 0.773(0.561–1.064) | 42.77(0.184) | 88.94(0.204) | 0.449 | 0.503 | 0.871(0.580–1.306) |
2 | 0110 | G G T C | 93.07(0.122) | 142.93(0.163) | 6.157 | 0.013* | 0.701(0.529–0.929) | 64.86(0.122) | 82.06(0.185) | 7.302 | 0.007* | 0.616(0.432–0.877) | 28.23(0.122) | 60.60(0.139) | 0.457 | 0.498 | 0.848(0.526–1.368) |
3 | 1010 | T C T C | 407.79(0.534) | 400.78(0.456) | 8.271 | 0.004* | 1.334(1.096–1.624) | 285.79(0.537) | 196.99(0.444) | 9.138 | 0.002* | 1.482(1.148–1.912) | 122.00(0.526) | 204.52(0.469) | 1.626 | 0.202 | 1.231(0.894–1.694) |
4 | 1100 | T G C C | 11.27(0.015) | 23.24(0.026) | 0 | 0 | 0 | 9.06(0.017) | 6.06(0.014) | 0 | 0 | 0 | 2.23(0.010) | 17.20(0.039) | 4.853 | 0.028* | 0.234(0.057–0.952) |
5 | 1110 | T G T C | 115.93(0.152) | 123.93(0.141) | 0.293 | 0.625 | 1.071(0.814–1.409) | 79.14(0.149) | 63.94(0.444) | 0.061 | 0.805 | 1.046(0.732–1.495) | 36.77(0.158) | 60.27(0.138) | 0.428 | 0.513 | 1.160(0.743–1.811) |