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Table 6 Haplotype analysis in patients with CAD and control subjects (Han Chinese)

From: The association of cholesterol absorption gene Numb polymorphism with Coronary Artery Disease among Han Chinese and Uighur Chinese in Xinjiang, China

    Total(n = 817) Male(n = 490) Female(n = 327)
    Case(freq) Control(freq) χ2 P value Odds ratio(95 % CI) Case(freq) Control(freq) χ2 P value Odds ratio(95 % CI) Case(freq) Control(freq) χ2 P value Odds ratio(95 % CI)
1 0100 G G C C 134.72(0.176) 183.90(0.209) 3.375 0.066 0.793(0.619–1.016) 91.93(0.173) 94.94(0.214) 2.500 0.114 0.773(0.561–1.064) 42.77(0.184) 88.94(0.204) 0.449 0.503 0.871(0.580–1.306)
2 0110 G G T C 93.07(0.122) 142.93(0.163) 6.157 0.013* 0.701(0.529–0.929) 64.86(0.122) 82.06(0.185) 7.302 0.007* 0.616(0.432–0.877) 28.23(0.122) 60.60(0.139) 0.457 0.498 0.848(0.526–1.368)
3 1010 T C T C 407.79(0.534) 400.78(0.456) 8.271 0.004* 1.334(1.096–1.624) 285.79(0.537) 196.99(0.444) 9.138 0.002* 1.482(1.148–1.912) 122.00(0.526) 204.52(0.469) 1.626 0.202 1.231(0.894–1.694)
4 1100 T G C C 11.27(0.015) 23.24(0.026) 0 0 0 9.06(0.017) 6.06(0.014) 0 0 0 2.23(0.010) 17.20(0.039) 4.853 0.028* 0.234(0.057–0.952)
5 1110 T G T C 115.93(0.152) 123.93(0.141) 0.293 0.625 1.071(0.814–1.409) 79.14(0.149) 63.94(0.444) 0.061 0.805 1.046(0.732–1.495) 36.77(0.158) 60.27(0.138) 0.428 0.513 1.160(0.743–1.811)
  1. CAD coronary artery disease, SNP single nucleotide polymorphism. The p value of haplotype was calculated by Fisher’s exact test. * p < 0.05.
  2. Haplotypes with frequencies >0.03 were estimated using SHEsis software; 0 represents major allele and 1 represents minor allele “0100” refers respectively the major allele of the SNP1,minor allele of the SNP2,major allele of the SNP3,major allele of the SNP4