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Table 7 Haplotype analysis in patients with CAD and control subjects (Uighur Chinese)

From: The association of cholesterol absorption gene Numb polymorphism with Coronary Artery Disease among Han Chinese and Uighur Chinese in Xinjiang, China

    Total(n = 857) Male(n = 582) Female(n = 275)
    Case(freq) Control(freq) χ2 P value Odds ratio(95 % CI) Case(freq) Control(freq) χ2 P value Odds ratio(95 % CI) Case(freq) Control(freq) χ2 P value Odds ratio(95 % CI)
1 0100 G G C C 305.11(0.303) 238.23(0.336) 2.284 0.131 0.853(0.693–1.049) 224.57(0.307) 133.44(0.342) 1.548 0.214 0.846(0.650–1.101) 80.43(0.294) 105.09(0.330) 1.082 0.298 0.830(0.584–1.179)
2 0110 G G T C 218.04(0.217) 148.10(0.209) 0.116 0.734 1.042(0.823–1.319) 154.87(0.212) 80.23(0.206) 0.045 0.833 1.033(0.762–1.400) 63.54(0.232) 67.89(0.213) 0.235 0.628 1.101(0.746–1.625)
3 1010 T C T C 333.07(0.331) 215.98(0.305) 1.021 0.273 1.123(0.912–1.383) 245.28(0.335) 118.66(0.304) 1.063 0.302 1.150(0.881–1.501) 87.67(0.320) 96.81(0.304) 0.115 0.735 1.062(0.749–1.508)
4 1100 T G C C 39.770.040) 21.50(0.030) 0.987 0.321 1.310(0.768–2.234) 25.32(0.035) 11.14(0.029) 0.287 0.592 1.216(0.594–2.487) 14.73(0.054) 10.38(0.033) 1.559 0.212 1.669(0.741–3.758)
5 1110 T G T C 88.09(0.088) 66.38(0.094) 0.215 0.643 0.924(0.661–1.291) 64.24(0.088) 36.19(0.093) 0.087 0.769 0.938(0.611–1.439) 23.46(0.086) 30.34(0.095) 0.199 0.656 0.879(0.500–1.548)
  1. CAD coronary artery disease, SNP single nucleotide polymorphism. The p value of haplotype was calculated by Fisher’s exact test. * P < 0.05.
  2. Haplotypes with frequencies >0.03 were estimated using SHEsis software; 0 represents major allele and 1 represents minor allele “0100” refers respectively the major allele of the SNP1,minor allele of the SNP2,major allele of the SNP3,major allele of the SNP4