| | | |
Total(n = 857)
|
Male(n = 582)
|
Female(n = 275)
|
|---|
| | | |
Case(freq)
|
Control(freq)
|
χ2
|
P value
|
Odds ratio(95 % CI)
|
Case(freq)
|
Control(freq)
|
χ2
|
P value
|
Odds ratio(95 % CI)
|
Case(freq)
|
Control(freq)
|
χ2
|
P value
|
Odds ratio(95 % CI)
|
|---|
|
1
|
0100
|
G G C C
|
305.11(0.303)
|
238.23(0.336)
|
2.284
|
0.131
|
0.853(0.693–1.049)
|
224.57(0.307)
|
133.44(0.342)
|
1.548
|
0.214
|
0.846(0.650–1.101)
|
80.43(0.294)
|
105.09(0.330)
|
1.082
|
0.298
|
0.830(0.584–1.179)
|
|
2
|
0110
|
G G T C
|
218.04(0.217)
|
148.10(0.209)
|
0.116
|
0.734
|
1.042(0.823–1.319)
|
154.87(0.212)
|
80.23(0.206)
|
0.045
|
0.833
|
1.033(0.762–1.400)
|
63.54(0.232)
|
67.89(0.213)
|
0.235
|
0.628
|
1.101(0.746–1.625)
|
|
3
|
1010
|
T C T C
|
333.07(0.331)
|
215.98(0.305)
|
1.021
|
0.273
|
1.123(0.912–1.383)
|
245.28(0.335)
|
118.66(0.304)
|
1.063
|
0.302
|
1.150(0.881–1.501)
|
87.67(0.320)
|
96.81(0.304)
|
0.115
|
0.735
|
1.062(0.749–1.508)
|
|
4
|
1100
|
T G C C
|
39.770.040)
|
21.50(0.030)
|
0.987
|
0.321
|
1.310(0.768–2.234)
|
25.32(0.035)
|
11.14(0.029)
|
0.287
|
0.592
|
1.216(0.594–2.487)
|
14.73(0.054)
|
10.38(0.033)
|
1.559
|
0.212
|
1.669(0.741–3.758)
|
|
5
|
1110
|
T G T C
|
88.09(0.088)
|
66.38(0.094)
|
0.215
|
0.643
|
0.924(0.661–1.291)
|
64.24(0.088)
|
36.19(0.093)
|
0.087
|
0.769
|
0.938(0.611–1.439)
|
23.46(0.086)
|
30.34(0.095)
|
0.199
|
0.656
|
0.879(0.500–1.548)
|
-
CAD coronary artery disease, SNP single nucleotide polymorphism. The p value of haplotype was calculated by Fisher’s exact test. *
P < 0.05.
- Haplotypes with frequencies >0.03 were estimated using SHEsis software; 0 represents major allele and 1 represents minor allele “0100” refers respectively the major allele of the SNP1,minor allele of the SNP2,major allele of the SNP3,major allele of the SNP4
