Genetic association of APOA5 and APOE with metabolic syndrome and their interaction with health-related behavior in Korean men

Table 2 The logistic regression results of significant SNPs for MetS and its components

Gene	SNP	Chr	Model	Phenotype (number of case / control)
				WC (460 / 733)		TG (348 / 845)		HDL (198 / 995)		BP (451 / 742)		Glucose (304 / 889)		MetS (254 / 939)
				OR (95%CI)	P-value	OR (95%CI)	P-value	OR (95%CI)	P-value	OR (95%CI)	P-value	OR (95%CI)	P-value	OR (95%CI)	P-value
APOA5	rs662799	11	Model 1^a	0.971 (0.80–1.17)	0.7550	1.609 (1.32–1.97)	3.25E-06	1.510 (1.19–1.92)	7.20E-04	1.033 (0.85–1.25)	0.7379	1.042 (0.84–1.29)	0.7019	1.498 (1.20–1.86)	2.90E-04
APOA5	rs662799	11	Model 2^b	1.009 (0.83–1.22)	0.9247	1.726 (1.40–2.13)	2.65E-07	1.654 (1.29–2.12)	7.04E-05	1.016 (0.84–1.23)	0.8766	1.100 (0.88–1.37)	0.3927	1.603 (1.28–2.01)	3.96E-05
APOE	rs769450	19	Model 1^a	0.894 (0.72–1.11)	0.3091	0.674 (0.53–0.86)	0.0015	1.072 (0.81–1.41)	0.6235	0.869 (0.70–1.08)	0.2080	0.994 (0.78–1.26)	0.9630	0.759 (0.58–0.99)	0.0427
APOE	rs769450	19	Model 2^b	0.893 (0.72–1.11)	0.3130	0.653 (0.51–0.84)	7.72E-04	1.016 (0.76–1.36)	0.9152	0.896 (0.72–1.12)	0.3316	0.979 (0.77–1.25)	0.8714	0.757 (0.58–0.99)	0.0448

MetS components cut-off: WC >90 Cm for men, TG > 150 mg/dL, HDL < 40 mg/dL, BP: SBP > 130 mmHg or DBP > 85 mmHg, Glucose > 100 mg/dL
Bold indicates significance of Bonfferoni adjusted P-value (<0.0029)
WC waist circumference, TG triglyceride, HDL high density lipoprotein, BP blood pressure, MetS Metabolic syndrome
^aModel 1: Adjusted for age and region of recruitment
^bModel 2: Further adjusted for smoking, alcohol and physical activity

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