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Table 2 The logistic regression results of significant SNPs for MetS and its components

From: Genetic association of APOA5 and APOE with metabolic syndrome and their interaction with health-related behavior in Korean men

Gene SNP Chr Model Phenotype (number of case / control)
WC (460 / 733) TG (348 / 845) HDL (198 / 995) BP (451 / 742) Glucose (304 / 889) MetS (254 / 939)
OR (95%CI) P-value OR (95%CI) P-value OR (95%CI) P-value OR (95%CI) P-value OR (95%CI) P-value OR (95%CI) P-value
APOA5 rs662799 11 Model 1a 0.971 (0.80–1.17) 0.7550 1.609 (1.32–1.97) 3.25E-06 1.510 (1.19–1.92) 7.20E-04 1.033 (0.85–1.25) 0.7379 1.042 (0.84–1.29) 0.7019 1.498 (1.20–1.86) 2.90E-04
Model 2b 1.009 (0.83–1.22) 0.9247 1.726 (1.40–2.13) 2.65E-07 1.654 (1.29–2.12) 7.04E-05 1.016 (0.84–1.23) 0.8766 1.100 (0.88–1.37) 0.3927 1.603 (1.28–2.01) 3.96E-05
APOE rs769450 19 Model 1a 0.894 (0.72–1.11) 0.3091 0.674 (0.53–0.86) 0.0015 1.072 (0.81–1.41) 0.6235 0.869 (0.70–1.08) 0.2080 0.994 (0.78–1.26) 0.9630 0.759 (0.58–0.99) 0.0427
Model 2b 0.893 (0.72–1.11) 0.3130 0.653 (0.51–0.84) 7.72E-04 1.016 (0.76–1.36) 0.9152 0.896 (0.72–1.12) 0.3316 0.979 (0.77–1.25) 0.8714 0.757 (0.58–0.99) 0.0448
  1. MetS components cut-off: WC >90 Cm for men, TG > 150 mg/dL, HDL < 40 mg/dL, BP: SBP > 130 mmHg or DBP > 85 mmHg, Glucose > 100 mg/dL
  2. Bold indicates significance of Bonfferoni adjusted P-value (<0.0029)
  3. WC waist circumference, TG triglyceride, HDL high density lipoprotein, BP blood pressure, MetS Metabolic syndrome
  4. aModel 1: Adjusted for age and region of recruitment
  5. bModel 2: Further adjusted for smoking, alcohol and physical activity