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Table 3 Clinical, biochemical and nutritional variables according to polymorphisms in APOA5, LEPR and APOA2 genes

From: Interaction of dietary fat intake with APOA2, APOA5 and LEPR polymorphisms and its relationship with obesity and dyslipidemia in young subjects

Variables Polymorphism −1131 T/C in the gene APOA5 P Polymorphism −265 T/C in the gene APOA2 P Polymorphism 668 A/G in the gene LEPR P
T/T T/C + C/C T/T T/C + C/C A/A A/G + G/G
n = 139 (69.5) n = 61 (30.5) n = 143 (71.5) n = 57 (28.5) n = 63 (31.5) n = 137 (68.5)
Clinical
Age (years)b 21 (20–22) 20 (19–22) 0.47 21 (19–22) 21 (20–22) 0.98 21 (20–23) 21 (19–22) 0.72
Weight (kg)b 74.3 (55.5–91.8) 69.5 (58.4–88.8) 0.76 74.3 (56.9–93.2) 68.2 (55.3–89.2) 0.80 75.7 (56.1–93.4) 69.5 (56.9–90.4) 0.94
BMI (kg/m2)b 30 (21.3–33.2) 24.4 (22–32.2) 0.72 30 (21.5–33) 24.1 (21.4–33.1) 0.62 30.7 (21.3–33.2) 24.7 (21.7–33) 0.92
Waist (cm)b 89 (78–106) 87 (79–105.8) 0.85 91.5 (79–106) 86 (77–102.5) 0.29 90 (78–106.5) 88.2 (78–104) 0.88
SBP (mmHg)a 109.3 ± 12.7 111.1 ± 12.9 0.35 110 ± 12.5 109.4 ± 13.6 0.77 108.4 ± 11.4 110.5 ± 13.4 0.28
DBP (mmHg)b 69 (64–75) 69 (63–76) 0.89 69 (63–76) 70 (64–74) 0.99 69 (63–76) 70 (64–75) 0.49
Biochemical
Glucose (mg/dL)b 84 (76–89) 82 (74–88) 0.34 83 (76–89) 83 (78–89) 0.54 84 (76–89) 83 (76–89) 0.70
Cholesterol (mg/dL)b 160 (143–185) 150 (136–177) 0.14 160 (141–182) 157 (142–179) 0.67 153 (142–171) 162 (141–191) 0.07
LDL-C (mg/dL)b 109 (87–132) 106 (84–125) 0.57 110 (83–130) 106 (88–131) 0.99 103 (75–119) 111 (88–138) 0.02
Triglycerides (mg/dL) 94 (69–144) 104 (74–145) 0.32 94 (70–151) 98 (63–121) 0.32 93 (63–129) 100 (73–148) 0.19
HDL-C (mg/dL)b 45 (38–54) 41 (35–48) 0.02 44 (37–51) 45 (37–53) 0.95 43 (37–51) 45 (37–53) 0.50
Nutritional
Total energy (kcal/d)b 2440 (2049–2860) 2411 (2179–2724) 0.79 2427 (2054–2854) 2411 (2130–2822) 0.86 2452 (2130–2764) 2418 (2022–2854) 0.72
Carbohydrates (g/d)b 318 (270.8–390) 318 (276–370) 0.87 318 (277–380) 320 (264–391) 0.74 318 (278–380) 318 (270–391) 0.89
Protein (g/d)b 105 (84–127) 100 (85–118.2) 0.56 101 (83–126) 107 (89–125) 0.63 108 (86.9–123) 101 (83–126) 0.46
Total fat (g/d)b 81 (61–98) 77 (65–95) 0.58 78 (62–96.5) 84 (61–97) 0.98 80 (65–97) 79 (61–96.5) 0.69
SFA (g/d)b 11 (8–16) 11 (8–15) 0.45 11 (9–15) 10 (7–15) 0.27 11 (8–14) 11 (8–16) 0.97
MUFA (g/d)b 17 (13–24) 16 (12–21) 0.18 17 (13–23) 16 (12–23) 0.23 17 (13–23) 17 (13–23) 0.86
PUFA (g/d)b 8 (6–12) 10 (8–12) 0.037 9 (7–13) 8 (6–10) 0.02 9 (7–12) 9 (6–12) 0.61
Cholesterol (mg/d)b 258 (172–359) 273 (152–329) 0.91 275 (186–345) 245 (143–328) 0.26 261 (143–329) 267 (181–357) 0.56
  1. BMI body mass index, SBP systolic blood pressure, DBP diastolic blood pressure, LDL low-density lipoprotein cholesterol, HDL high-density lipoprotein cholesterol, SFA saturated fatty acids, MUFA monounsaturated fatty acids, PUFA polyunsaturated fatty acids
  2. aData provided in Mean ± SD; Student t test
  3. bData provided in Median (percentile 25–75); Mann Whitney test