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Table 1 The tag SNPs of KCNB1 associated with lipid metabolism and insulin resistance

From: Association of KCNB1 polymorphisms with lipid metabolisms and insulin resistance: a case-control design of population-based cross-sectional study in Chinese Han population

 

Genotype

M/F

Age

BMI

WHR

TC

TG

HDL-C

LDL-C

FPG

FINS

HOMA-IR

HOMA-B

rs16994565

TT

267/341

39.68 ± 10.05

23.10 ± 2.48

0.80 ±  0.07

4.60 ± 0.84

1.11 ± 0.61

1.67 ± 0.34

2.67 ± 0.71

4.94 ± 0.48

8.91 ± 3.29

1.15 ± 0.42

108.58 ± 32.51

 

TC

40/66

39.91 ± 11.26

22.95 ± 2.73

079 ± 0.07

4.46 ± 0.80

1.02 ± 0.57

1.66 ± 0.30

2.54 ± 0.67

4.90 ± 0.47

8.88 ± 3.26

1.14 ± 0.42

109.46 ± 30.33

 

CC

3/4

36.00 ± 9.52

22.39 ± 2.90

0.77 ± 0.07

3.75 ± 1.71

0.98 ± 0.31

1.64 ± 0.25

2.49 ± 0.34

4.85 ± 0.33

8.63 ± 1.09

1.10 ± 0.15

110.49 ± 19.00

P 1

 

0.5

0.62

0.67

0.51

0.01

0.31

0.95

0.18

0.75

0.97

0.95

0.82

P 2(TC vs CC)

   

0.83,0.21(-1.71,2.13)

0.23,0.02(-0.01,0.06)

0.08,0.58(-0.06,1.23)

0.99,0.001(-0.39,0.39)

0.90,-0.01(-0.22,0.20)

0.95,-0.01(-0.50,0,48)

0.84,-0.03(-0.35,0.29)

0.81,0.31(-2.17,2.79)

0.78,-0.05(-0.28,0.37)

0.80,2.81(-19.05,24.67)

P 2(TT vs CC)

   

0.60,0.23(-0.62,1.08)

0.24,0.01(-0.01,0.03)

0.02,0.36(0.06,0.66)

0.74,0.03(-0.17,0.24)

0.93,0.01(-0.11,0.12)

0.73,0.04(-0.20,0.29)

0.91,0.01(-0.16,0.17)

0.78,0.18(-1.04,1.39)

0.73,0.03(-0.13,0.18)

0.92,0.64(-11.04,12.31)

rs237460

GG

101/128

39.34 ± 10.39

22.92 ± 2.58

0.795 ± 0.07

4.51 ± 0.91

1.07 ± 0.56

1.66 ± 0.30

2.64 ± 0.73

4.91 ± 0.47

8.63 ± 3.26

1.11 ± 0.42

106.55 ± 29.15

 

GA

157/204

39.85 ± 10.20

23.13 ± 2.52

0.798 ± 0.07

4.55 ± 0.82

1.11 ± 0.60

1.65 ± 0.34

2.60 ± 0.69

4.94 ± 0.48

9.00 ± 3.25

1.16 ± 0.42

109.16 ± 32.36

 

AA

53/80

40.09 ± 10.36

23.20 ± 2.45

0.796 ± 0.07

4.73 ± 0.80

1.12 ± 0.64

1.72 ± 0.34

2.78 ± 0.69

4.94 ± 0.46

9.11 ± 3.34

1.17 ± 0.42

110.98 ± 35.76

P 1

 

0.71

0.77

0.52

0.87

0.04

0.67

0.13

0.06

0.82

0.29

0.33

0.24

P 2(GA vs AA)

   

0.66,-0.10(-0.56,0.36)

0.89,-0.001(-0.01,0.01)

0.02,-0.19(-0.34,-0.04)

0.62,-0.03(-0.14,0.08)

0.07,-0.06(-0.12,0.01)

0.005,-0.18(-0.31,-0.06)

0.98,-0.001(-0.09,0.09)

0.66,-0.15(-0.79.0.50)

0.75,-0.01(-0.10,0.07)

0.49,-2.23(-8.63,4.17)

P 2(GG vs AA)

   

0.26,-0.14(-0.39,0.11)

0.51,-0.002(-0.01,0.003)

0.02,-0.11(-0.19,-0.02)

0.31,-0.03(-0.09,0.03)

0.15,-0.02(-0.06,0.10)

0.07,-0.07(-0.14,0.004)

0.73,-0.01(-0.06,0.04)

0.15,-0.26(-0.61,0.10)

0.19-,0.03(-0.08,0.02)

0.13,-2.53(-5.82,0.77)

rs3331

TT

270/348

39.48 ± 10.06

23.08 ± 2.51

0.80 ± 0.07

4.59 ± 0.84

1.11 ± 0.60

1.67 ± 0.34

2.66 ± 0.71

4.93 ± 0.48

8.90 ± 3.28

1.15 ± 0.42

108.53 ± 32.33

 

TC

40/59

41.15 ± 11.36

23.08 ± 2.61

0.80 ± 0.06

4.48 ± 0.79

1.03 ± 0.59

1.63 ± 0.27

2.57 ± 0.68

4.91 ± 0.46

8.97 ± 3.29

1.15 ± 0.43

110.04 ± 30.98

 

CC

1/4

39.2 ± 11.48

22.64 ± 3.22

0.76 ± 0.06

3.57 ± 2.05

0.94 ± 0.33

1.69 ± 0.15

2.58 ± 0.38

4.85 ± 0.25

7.94 ± 1.16

1.02 ± 0.16

104.26 ± 17.80

P 1

 

0.48

0.32

0.93

0.31

0.02

0.42

0.71

0.47

0.8

0.79

0.78

0.97

P 2(TC vs CC)

   

0.96,0.06(-2.11,2.24)

0.22,0.03(-0.02,0.07)

0.03,0.83(0.09,1.57)

0.94,-0.02(-0.50,0.47)

0.83,-0.03(-0.25,0.20)

0.73,-0.10(-0.68,0.48)

0.82,0.04(-0.33,0.42)

0.55,0.90(-2.07,3.87)

0.54,0.12(-0.27,0.51)

0.69,5.43(21.04,31.89)

P 2 (TT vs CC)

   

0.95,0.03(-0.99,1.05)

0.43,0.01(-0.01,0.03)

0.01,0.49(0.13,0.84)

0.79,0.03(-0.21,0.27)

0.81,0.02(-0.12,0.16)

0.97,-0.01(-0.29,0.28)

0.80,0.03(-0.17,0.22)

0.58,0.40(-1.03,1.84)

0.57,0.05(-0.13,0.24)

0.77,2.08(-11.64,15.80)

rs802950

CC

212/276

39.63 ± 10.27

23.09 ± 2.52

0.80 ± 0.07

4.60 ± 0.86

1.12 ± 0.60

1.67 ± 0.33

2.67 ± 0.71

4.92 ± 0.48

8.85 ± 3.29

1.14 ± 0.42

108.67 ± 31.87

 

AC

89/118

39.58 ± 10.25

23.06 ± 2.52

0.79 ± 0.07

4.47 ± 0.84

1.05 ± 0.58

1.64 ± 0.33

2.58 ± 0.69

4.96 ± 0.49

9.03 ± 3.21

1.17 ± 0.41

108.84 ± 32.97

 

AA

10/19

42.45 ± 10.06

22.96 ± 2.61

0.80 ± 0.06

4.90 ± 0.85

1.12 ± 0.73

1.79 ± 029

2.79 ± 0.68

4.94 ± 0.35

9.02 ± 3.39

1.16 ± 0.44

108.07 ± 29.56

P 1

 

0.64

0.35

0.96

0.29

0.02

0.44

0.07

0.18

0.58

0.79

0.75

0.58

P 2(AC vs AA)

   

0.69,0.18(-0.71,1.07)

0.32,-0.01(-0.03,0.01)

0.03,-0.36(-0.68,-0.05)

0.56,-0.06(-0.28,0.15)

0.06,-0.12(-0.24,0.01)

0.14,-0.19(-0.45,0.06)

0.36,0.08(-0.09,0.24)

0.98,-0.02(-1.29,1.25)

0.93,0.01(-0.16,0.17)

0.78,-1.77(-14.19,10.66)

P 2(CC vs AA)

   

0.65,0.10(-0.34,0.54)

0.88,0.001(-0.01.0.01)

0.17,-0.11(-0.26,0.05)

0.99,0.001(-0.11,0.11)

0.12,-0.05(-0.11,0.01)

0.61,-0.03(-0.16,0.09)

0.85,0.01(-0.08,0.09)

0.61,-0.16(-0.77,0.46)

0.66,-0.02(-0.10,0.06)

0.72,-1.06(-6.79,4.67)

rs926672

AA

97/145

39.66 ± 10.39

22.91 ± 2.43

0.80 ± 0.07

4.57 ± 0.90

1.10 ± 0.58

1.69 ± 0.35

2.63 ± 0.74

4.93 ± 0.44

8.66 ± 3.15

1.12 ± 0.41

106.19 ± 29.59

 

AT

165/190

39.69 ± 10.29

23.28 ± 2.61

0.80 ± 0.07

4.61 ± 0.81

1.15 ± 0.65

1.65 ± 0.32

2.68 ± 0.69

4.94 ± 0.51

9.23 ± 3.41

1.19 ± 0.44

111.47 ± 34.21

 

TT

48/76

39.89 ± 10.00

23.78 ± 2.42

0.79 ± 0.07

4.44 ± 0.86

0.94 ± 0.45

1.66 ± 0.31

2.61 ± 0.65

4.91 ± 0.43

8.43 ± 3.01

1.08 ± 0.39

105.49 ± 29.76

P 1

 

0.17

0.98

0.08

0.21

0.19

0.004

0.44

0.53

0.83

0.02

0.02

0.07

P 2(AT vs TT)

   

0.13,0.38(-0.11,0.88)

0.17,0.01(-0.003,0.02)

0.049,0.16(0.00,0.32)

0.002,0.19(0.07,0.30)

0.90,0.004(-0.06,0.07)

0.46,0.05(-0.08,0.18)

0.62,0.02(-0.07,0.12)

0.03,0.74(0.06,1,42)

0.02,0.10(0.01,0.19)

0.09,5.66(-0.86,12.18)

P 2(AA vs TT)

   

0.60,0.07(-0.18,0.31)

0.15,0.004(-0.001,0.01)

0.16,0.06(-0.13,0.16)

0.004,0.08(0.02,0.13)

0.46,0.01(-0.02,0.05)

0.75,0.01(-0.06,0.08)

0.62,0.01(-0.03,0.06)

0.53,0.11(-0.23,0.44)

0.45,0.02(-0.03,0.06)

0.88,0.24(-2.83,3.31)

rs1051295

TT

111/147

39.96 ± 10.82

22.97 ± 2.50

0.80 ± 0.07

4.65 ± 0.92

1.13 ± 0.58

1.67 ± 0.35

2.71 ± 0.80

4.93 ± 0.51

9.08 ± 3.34

1.17 ± 0.43

110.43 ± 33.11

 

TC

153/203

40.33 ± 10.16

23.10 ± 2.50

0.79 ± 0.07

4.54 ± 0.83

1.12 ± 0.65

1.66 ± 0.34

2.63 ± 0.64

4.94 ± 0.44

8.95 ± 3.26

1.15 ± 0.42

108.35 ± 31.32

 

CC

51/68

38.3 ± 9.81

23.29 ± 2.66

0.79 ± 0.07

4.49 ± 0.73

0.99 ± 0.45

1.68 ± 0.28

2.61 ± 0.67

4.93 ± 0.50

8.52 ± 3.06

1.10 ± 0.39

105.98 ± 31.02

P 1

 

1

0.18

0.51

0.42

0.13

0.08

0.76

0.22

0.9

0.29

0.24

0.44

P 2(TC vs CC)

   

0.16,-0.35(-0.83,0.13)

0.42,-0.004(-0.01,001)

0.88,0.11(-0.15,0.18)

0.10,0.10(-002,0.22)

0.51,-0.02(-0.09,0.04)

0.78,-0.02(-0.14,0.11)

0.73,-0.02(-0.11,0.07)

0.16,0.48(-0.19,1.15)

0.16,0.06(-0.03,0.15)

0.21,4.07(-2.23,10.36)

P 2(TT vs CC)

   

0.09,-0.22(-0.48,0.04)

0.60,0.001(-0.004,0.01)

0.19,0.06(-0.03,0.15)

0.03,0.06(0.01,0.12)

0.66,-0.01(-0.04,0.03)

0.39,0.03(-0.04,0.11)

0.49,-0.02(-0.07,0.03)

0.11,2.92(-0.06,0.65)

0.09,0.04(-0.01,0.09)

0.09,2.96(-0.45,6.36)

rs2057077

CC

102/160

39.42 ± 10.30

22.89 ± 2.52

0.79 ± 0.07

4.55 ± 0.92

1.07 ± 0.58

1.67 ± 0.33

2.62 ± 0.72

4.93 ± 0.45

8.64 ± 3.18

1.11 ± 0.41

105.91 ± 28.55

 

TC

170/193

39.74 ± 10.28

23.22 ± 2.58

0.80 ± 0.07

4.58 ± 0.82

1.13 ± 0.61

1.65 ± 0.33

2.68 ± 0.69

4.94 ± 0.48

9.26 ± 3.36

1.19 ± 0.43

111.55 ± 34.05

 

TT

40/60

40.71 ± 10.32

23.04 ± 2.27

0.79 ± 0.07

4.59 ± 0.80

1.04 ± 0.60

1.67 ± 0.33

2.66 ± 0.72

4.90 ± 0.51

8.29 ± 3.03

1.06 ± 0.39

105.53 ± 32.51

P 1

 

0.12

0.57

0.26

0.52

0.91

0.25

0.73

0.59

0.76

0.01

0.005

0.02

P 2(TC vs TT)

   

0.60,0.14(-0.39,0.67)

0.86,0.001(-0.01,0.01)

0.88,0.01(-0.16,0.18)

0.19,0.08(-0.04,0.21)

0.96,0.002(-0.07,0.07)

0.83,0.03(-0.13,0.16)

0.36,0.05(-0.05,0.15)

0.01,0.92(0.19,1.65)

0.008,0.13(0.03,0.23)

0.17,5.06(-2.17,12.29)

P 2(CC vs TT)

   

0.83,-0.03(-0.29,0.24)

0.51,0.002(-0.004,0.01)

0.90,0.006(-0.09,0.10)

0.31,0.03(-0.03,0.09)

0.95,0.001(-0.03,0.04)

0.95,-0.003(-0.08,0.07)

0.27,0.03(-0.02,0.08)

0.36,0.17(-0.19,0.53)

0.29,0.03(-0.02,0.72)

0.83,-0.35(-3.63,2.92)

rs4810952

TT

81/126

39.43 ± 10.15

22.97 ± 2.46

0.79 ± 0.07

4.58 ± 0.89

1.08 ± 0.58

1.68 ± 0.34

2.65 ± 0.73

4.94 ± 0.43

8.40 ± 3.18

1.10 ± 0.41

103.09 ± 28.72

 

TC

170/194

39.82 ± 10.33

23.16 ± 2.61

0.80 ± 0.07

4.59 ± 0.82

1.14 ± 0.62

1.66 ± 0.33

2.66 ± 0.71

4.93 ± 0.50

9.30 ± 3.37

1.20 ± 0.43

112.54 ± 34.05

 

CC

60/91

39,79 ± 10.27

23.02 ± 2.40

0.79 ± 0.06

4.59 ± 0.87

1.02 ± 0.57

1.65 ± 0.31

2.61 ± 0.64

4.92 ± 0.46

8.62 ± 3.04

1.11 ± 0.39

107.17 ± 30.30

P 1

 

0.14

0.9

0.67

0.25

0.56

0.11

0.56

0.76

0.88

0.004

0.004

0.01

P 2(TC vs TT)

   

0.91,0.03(-0.38,0.43)

0.87,-0.001(-0.01,0.01)

0.85,-0.01(-0.15,0.13)

0.61,0.03(-0.07,0.12)

0.78,-0.01(-0.06,0.05)

0.74,-0.02(-0.14,0.10)

0.41,-0.03(-0.11,0.04)

0.003,0.86(0.30,1.43)

0.004,0.11(0.04,0.18)

<0.001,9.60(4.27,14.93)

P 2(CC vs TT)

   

0.93,0.01(-0.23,0.25)

0.52,-0.002(-0.01,0.003)

0.30,-0.05(-0.13,0.04)

0.26,-0.03(-0.09,0.02)

0.30,-0.02(-0.06,0.02)

0.52,-0.02(-0.09,0.05)

0.50,-0.02(-0.06,0.03)

0.48,0.12(-0.21,0.44)

0.59,0.01(-0.03,0.06)

0.15,2.18(-0.79,5.16)

  1. Data are present as mean ± SD, M/F male/female, WHR Waist to hip ratio, TG triglycerides, TC serum total cholesterol, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, FPG fasting plasma glucose, FINS fasting serum insulin, P 1 from one-way ANOVA test except P 1for M/F from χ 2 test, P 2 from multiple linear regression analysis with b and 95 % CIs (adjusted for age and gender)