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Table 1 The tag SNPs of KCNB1 associated with lipid metabolism and insulin resistance

From: Association of KCNB1 polymorphisms with lipid metabolisms and insulin resistance: a case-control design of population-based cross-sectional study in Chinese Han population

  Genotype M/F Age BMI WHR TC TG HDL-C LDL-C FPG FINS HOMA-IR HOMA-B
rs16994565 TT 267/341 39.68 ± 10.05 23.10 ± 2.48 0.80 ±  0.07 4.60 ± 0.84 1.11 ± 0.61 1.67 ± 0.34 2.67 ± 0.71 4.94 ± 0.48 8.91 ± 3.29 1.15 ± 0.42 108.58 ± 32.51
  TC 40/66 39.91 ± 11.26 22.95 ± 2.73 079 ± 0.07 4.46 ± 0.80 1.02 ± 0.57 1.66 ± 0.30 2.54 ± 0.67 4.90 ± 0.47 8.88 ± 3.26 1.14 ± 0.42 109.46 ± 30.33
  CC 3/4 36.00 ± 9.52 22.39 ± 2.90 0.77 ± 0.07 3.75 ± 1.71 0.98 ± 0.31 1.64 ± 0.25 2.49 ± 0.34 4.85 ± 0.33 8.63 ± 1.09 1.10 ± 0.15 110.49 ± 19.00
P 1   0.5 0.62 0.67 0.51 0.01 0.31 0.95 0.18 0.75 0.97 0.95 0.82
P 2(TC vs CC)     0.83,0.21(-1.71,2.13) 0.23,0.02(-0.01,0.06) 0.08,0.58(-0.06,1.23) 0.99,0.001(-0.39,0.39) 0.90,-0.01(-0.22,0.20) 0.95,-0.01(-0.50,0,48) 0.84,-0.03(-0.35,0.29) 0.81,0.31(-2.17,2.79) 0.78,-0.05(-0.28,0.37) 0.80,2.81(-19.05,24.67)
P 2(TT vs CC)     0.60,0.23(-0.62,1.08) 0.24,0.01(-0.01,0.03) 0.02,0.36(0.06,0.66) 0.74,0.03(-0.17,0.24) 0.93,0.01(-0.11,0.12) 0.73,0.04(-0.20,0.29) 0.91,0.01(-0.16,0.17) 0.78,0.18(-1.04,1.39) 0.73,0.03(-0.13,0.18) 0.92,0.64(-11.04,12.31)
rs237460 GG 101/128 39.34 ± 10.39 22.92 ± 2.58 0.795 ± 0.07 4.51 ± 0.91 1.07 ± 0.56 1.66 ± 0.30 2.64 ± 0.73 4.91 ± 0.47 8.63 ± 3.26 1.11 ± 0.42 106.55 ± 29.15
  GA 157/204 39.85 ± 10.20 23.13 ± 2.52 0.798 ± 0.07 4.55 ± 0.82 1.11 ± 0.60 1.65 ± 0.34 2.60 ± 0.69 4.94 ± 0.48 9.00 ± 3.25 1.16 ± 0.42 109.16 ± 32.36
  AA 53/80 40.09 ± 10.36 23.20 ± 2.45 0.796 ± 0.07 4.73 ± 0.80 1.12 ± 0.64 1.72 ± 0.34 2.78 ± 0.69 4.94 ± 0.46 9.11 ± 3.34 1.17 ± 0.42 110.98 ± 35.76
P 1   0.71 0.77 0.52 0.87 0.04 0.67 0.13 0.06 0.82 0.29 0.33 0.24
P 2(GA vs AA)     0.66,-0.10(-0.56,0.36) 0.89,-0.001(-0.01,0.01) 0.02,-0.19(-0.34,-0.04) 0.62,-0.03(-0.14,0.08) 0.07,-0.06(-0.12,0.01) 0.005,-0.18(-0.31,-0.06) 0.98,-0.001(-0.09,0.09) 0.66,-0.15(-0.79.0.50) 0.75,-0.01(-0.10,0.07) 0.49,-2.23(-8.63,4.17)
P 2(GG vs AA)     0.26,-0.14(-0.39,0.11) 0.51,-0.002(-0.01,0.003) 0.02,-0.11(-0.19,-0.02) 0.31,-0.03(-0.09,0.03) 0.15,-0.02(-0.06,0.10) 0.07,-0.07(-0.14,0.004) 0.73,-0.01(-0.06,0.04) 0.15,-0.26(-0.61,0.10) 0.19-,0.03(-0.08,0.02) 0.13,-2.53(-5.82,0.77)
rs3331 TT 270/348 39.48 ± 10.06 23.08 ± 2.51 0.80 ± 0.07 4.59 ± 0.84 1.11 ± 0.60 1.67 ± 0.34 2.66 ± 0.71 4.93 ± 0.48 8.90 ± 3.28 1.15 ± 0.42 108.53 ± 32.33
  TC 40/59 41.15 ± 11.36 23.08 ± 2.61 0.80 ± 0.06 4.48 ± 0.79 1.03 ± 0.59 1.63 ± 0.27 2.57 ± 0.68 4.91 ± 0.46 8.97 ± 3.29 1.15 ± 0.43 110.04 ± 30.98
  CC 1/4 39.2 ± 11.48 22.64 ± 3.22 0.76 ± 0.06 3.57 ± 2.05 0.94 ± 0.33 1.69 ± 0.15 2.58 ± 0.38 4.85 ± 0.25 7.94 ± 1.16 1.02 ± 0.16 104.26 ± 17.80
P 1   0.48 0.32 0.93 0.31 0.02 0.42 0.71 0.47 0.8 0.79 0.78 0.97
P 2(TC vs CC)     0.96,0.06(-2.11,2.24) 0.22,0.03(-0.02,0.07) 0.03,0.83(0.09,1.57) 0.94,-0.02(-0.50,0.47) 0.83,-0.03(-0.25,0.20) 0.73,-0.10(-0.68,0.48) 0.82,0.04(-0.33,0.42) 0.55,0.90(-2.07,3.87) 0.54,0.12(-0.27,0.51) 0.69,5.43(21.04,31.89)
P 2 (TT vs CC)     0.95,0.03(-0.99,1.05) 0.43,0.01(-0.01,0.03) 0.01,0.49(0.13,0.84) 0.79,0.03(-0.21,0.27) 0.81,0.02(-0.12,0.16) 0.97,-0.01(-0.29,0.28) 0.80,0.03(-0.17,0.22) 0.58,0.40(-1.03,1.84) 0.57,0.05(-0.13,0.24) 0.77,2.08(-11.64,15.80)
rs802950 CC 212/276 39.63 ± 10.27 23.09 ± 2.52 0.80 ± 0.07 4.60 ± 0.86 1.12 ± 0.60 1.67 ± 0.33 2.67 ± 0.71 4.92 ± 0.48 8.85 ± 3.29 1.14 ± 0.42 108.67 ± 31.87
  AC 89/118 39.58 ± 10.25 23.06 ± 2.52 0.79 ± 0.07 4.47 ± 0.84 1.05 ± 0.58 1.64 ± 0.33 2.58 ± 0.69 4.96 ± 0.49 9.03 ± 3.21 1.17 ± 0.41 108.84 ± 32.97
  AA 10/19 42.45 ± 10.06 22.96 ± 2.61 0.80 ± 0.06 4.90 ± 0.85 1.12 ± 0.73 1.79 ± 029 2.79 ± 0.68 4.94 ± 0.35 9.02 ± 3.39 1.16 ± 0.44 108.07 ± 29.56
P 1   0.64 0.35 0.96 0.29 0.02 0.44 0.07 0.18 0.58 0.79 0.75 0.58
P 2(AC vs AA)     0.69,0.18(-0.71,1.07) 0.32,-0.01(-0.03,0.01) 0.03,-0.36(-0.68,-0.05) 0.56,-0.06(-0.28,0.15) 0.06,-0.12(-0.24,0.01) 0.14,-0.19(-0.45,0.06) 0.36,0.08(-0.09,0.24) 0.98,-0.02(-1.29,1.25) 0.93,0.01(-0.16,0.17) 0.78,-1.77(-14.19,10.66)
P 2(CC vs AA)     0.65,0.10(-0.34,0.54) 0.88,0.001(-0.01.0.01) 0.17,-0.11(-0.26,0.05) 0.99,0.001(-0.11,0.11) 0.12,-0.05(-0.11,0.01) 0.61,-0.03(-0.16,0.09) 0.85,0.01(-0.08,0.09) 0.61,-0.16(-0.77,0.46) 0.66,-0.02(-0.10,0.06) 0.72,-1.06(-6.79,4.67)
rs926672 AA 97/145 39.66 ± 10.39 22.91 ± 2.43 0.80 ± 0.07 4.57 ± 0.90 1.10 ± 0.58 1.69 ± 0.35 2.63 ± 0.74 4.93 ± 0.44 8.66 ± 3.15 1.12 ± 0.41 106.19 ± 29.59
  AT 165/190 39.69 ± 10.29 23.28 ± 2.61 0.80 ± 0.07 4.61 ± 0.81 1.15 ± 0.65 1.65 ± 0.32 2.68 ± 0.69 4.94 ± 0.51 9.23 ± 3.41 1.19 ± 0.44 111.47 ± 34.21
  TT 48/76 39.89 ± 10.00 23.78 ± 2.42 0.79 ± 0.07 4.44 ± 0.86 0.94 ± 0.45 1.66 ± 0.31 2.61 ± 0.65 4.91 ± 0.43 8.43 ± 3.01 1.08 ± 0.39 105.49 ± 29.76
P 1   0.17 0.98 0.08 0.21 0.19 0.004 0.44 0.53 0.83 0.02 0.02 0.07
P 2(AT vs TT)     0.13,0.38(-0.11,0.88) 0.17,0.01(-0.003,0.02) 0.049,0.16(0.00,0.32) 0.002,0.19(0.07,0.30) 0.90,0.004(-0.06,0.07) 0.46,0.05(-0.08,0.18) 0.62,0.02(-0.07,0.12) 0.03,0.74(0.06,1,42) 0.02,0.10(0.01,0.19) 0.09,5.66(-0.86,12.18)
P 2(AA vs TT)     0.60,0.07(-0.18,0.31) 0.15,0.004(-0.001,0.01) 0.16,0.06(-0.13,0.16) 0.004,0.08(0.02,0.13) 0.46,0.01(-0.02,0.05) 0.75,0.01(-0.06,0.08) 0.62,0.01(-0.03,0.06) 0.53,0.11(-0.23,0.44) 0.45,0.02(-0.03,0.06) 0.88,0.24(-2.83,3.31)
rs1051295 TT 111/147 39.96 ± 10.82 22.97 ± 2.50 0.80 ± 0.07 4.65 ± 0.92 1.13 ± 0.58 1.67 ± 0.35 2.71 ± 0.80 4.93 ± 0.51 9.08 ± 3.34 1.17 ± 0.43 110.43 ± 33.11
  TC 153/203 40.33 ± 10.16 23.10 ± 2.50 0.79 ± 0.07 4.54 ± 0.83 1.12 ± 0.65 1.66 ± 0.34 2.63 ± 0.64 4.94 ± 0.44 8.95 ± 3.26 1.15 ± 0.42 108.35 ± 31.32
  CC 51/68 38.3 ± 9.81 23.29 ± 2.66 0.79 ± 0.07 4.49 ± 0.73 0.99 ± 0.45 1.68 ± 0.28 2.61 ± 0.67 4.93 ± 0.50 8.52 ± 3.06 1.10 ± 0.39 105.98 ± 31.02
P 1   1 0.18 0.51 0.42 0.13 0.08 0.76 0.22 0.9 0.29 0.24 0.44
P 2(TC vs CC)     0.16,-0.35(-0.83,0.13) 0.42,-0.004(-0.01,001) 0.88,0.11(-0.15,0.18) 0.10,0.10(-002,0.22) 0.51,-0.02(-0.09,0.04) 0.78,-0.02(-0.14,0.11) 0.73,-0.02(-0.11,0.07) 0.16,0.48(-0.19,1.15) 0.16,0.06(-0.03,0.15) 0.21,4.07(-2.23,10.36)
P 2(TT vs CC)     0.09,-0.22(-0.48,0.04) 0.60,0.001(-0.004,0.01) 0.19,0.06(-0.03,0.15) 0.03,0.06(0.01,0.12) 0.66,-0.01(-0.04,0.03) 0.39,0.03(-0.04,0.11) 0.49,-0.02(-0.07,0.03) 0.11,2.92(-0.06,0.65) 0.09,0.04(-0.01,0.09) 0.09,2.96(-0.45,6.36)
rs2057077 CC 102/160 39.42 ± 10.30 22.89 ± 2.52 0.79 ± 0.07 4.55 ± 0.92 1.07 ± 0.58 1.67 ± 0.33 2.62 ± 0.72 4.93 ± 0.45 8.64 ± 3.18 1.11 ± 0.41 105.91 ± 28.55
  TC 170/193 39.74 ± 10.28 23.22 ± 2.58 0.80 ± 0.07 4.58 ± 0.82 1.13 ± 0.61 1.65 ± 0.33 2.68 ± 0.69 4.94 ± 0.48 9.26 ± 3.36 1.19 ± 0.43 111.55 ± 34.05
  TT 40/60 40.71 ± 10.32 23.04 ± 2.27 0.79 ± 0.07 4.59 ± 0.80 1.04 ± 0.60 1.67 ± 0.33 2.66 ± 0.72 4.90 ± 0.51 8.29 ± 3.03 1.06 ± 0.39 105.53 ± 32.51
P 1   0.12 0.57 0.26 0.52 0.91 0.25 0.73 0.59 0.76 0.01 0.005 0.02
P 2(TC vs TT)     0.60,0.14(-0.39,0.67) 0.86,0.001(-0.01,0.01) 0.88,0.01(-0.16,0.18) 0.19,0.08(-0.04,0.21) 0.96,0.002(-0.07,0.07) 0.83,0.03(-0.13,0.16) 0.36,0.05(-0.05,0.15) 0.01,0.92(0.19,1.65) 0.008,0.13(0.03,0.23) 0.17,5.06(-2.17,12.29)
P 2(CC vs TT)     0.83,-0.03(-0.29,0.24) 0.51,0.002(-0.004,0.01) 0.90,0.006(-0.09,0.10) 0.31,0.03(-0.03,0.09) 0.95,0.001(-0.03,0.04) 0.95,-0.003(-0.08,0.07) 0.27,0.03(-0.02,0.08) 0.36,0.17(-0.19,0.53) 0.29,0.03(-0.02,0.72) 0.83,-0.35(-3.63,2.92)
rs4810952 TT 81/126 39.43 ± 10.15 22.97 ± 2.46 0.79 ± 0.07 4.58 ± 0.89 1.08 ± 0.58 1.68 ± 0.34 2.65 ± 0.73 4.94 ± 0.43 8.40 ± 3.18 1.10 ± 0.41 103.09 ± 28.72
  TC 170/194 39.82 ± 10.33 23.16 ± 2.61 0.80 ± 0.07 4.59 ± 0.82 1.14 ± 0.62 1.66 ± 0.33 2.66 ± 0.71 4.93 ± 0.50 9.30 ± 3.37 1.20 ± 0.43 112.54 ± 34.05
  CC 60/91 39,79 ± 10.27 23.02 ± 2.40 0.79 ± 0.06 4.59 ± 0.87 1.02 ± 0.57 1.65 ± 0.31 2.61 ± 0.64 4.92 ± 0.46 8.62 ± 3.04 1.11 ± 0.39 107.17 ± 30.30
P 1   0.14 0.9 0.67 0.25 0.56 0.11 0.56 0.76 0.88 0.004 0.004 0.01
P 2(TC vs TT)     0.91,0.03(-0.38,0.43) 0.87,-0.001(-0.01,0.01) 0.85,-0.01(-0.15,0.13) 0.61,0.03(-0.07,0.12) 0.78,-0.01(-0.06,0.05) 0.74,-0.02(-0.14,0.10) 0.41,-0.03(-0.11,0.04) 0.003,0.86(0.30,1.43) 0.004,0.11(0.04,0.18) <0.001,9.60(4.27,14.93)
P 2(CC vs TT)     0.93,0.01(-0.23,0.25) 0.52,-0.002(-0.01,0.003) 0.30,-0.05(-0.13,0.04) 0.26,-0.03(-0.09,0.02) 0.30,-0.02(-0.06,0.02) 0.52,-0.02(-0.09,0.05) 0.50,-0.02(-0.06,0.03) 0.48,0.12(-0.21,0.44) 0.59,0.01(-0.03,0.06) 0.15,2.18(-0.79,5.16)
  1. Data are present as mean ± SD, M/F male/female, WHR Waist to hip ratio, TG triglycerides, TC serum total cholesterol, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, FPG fasting plasma glucose, FINS fasting serum insulin, P 1 from one-way ANOVA test except P 1for M/F from χ 2 test, P 2 from multiple linear regression analysis with b and 95 % CIs (adjusted for age and gender)