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Fig. 1 | Lipids in Health and Disease

Fig. 1

From: Mevalonate inhibits acid sphingomyelinase activity, increases sphingomyelin levels and inhibits cell proliferation of HepG2 and Caco-2 cells

Fig. 1

Dose dependent effects of mevalonate on acid SMase activity in HepG2 and Caco2 cells. The cells were incubated with mevalonate at different concentrations for 24 and 48 h. The acid SMase activity in the cell-free extracts was determined using choline labeled 14C-SM as substrate. The activity was adjusted to protein levels in the sample and expressed as percentage of the control (0 concentration of mevalonate). Results are means ± SD obtained from triple culture wells in three separate experiments. **p < 0.01, ***p < 0.005 compared with the control

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Lipids in Health and Disease

ISSN: 1476-511X