Resveratrol ameliorates hepatic steatosis and inflammation in methionine/choline-deficient diet-induced steatohepatitis through regulating autophagy

Table 1 Resveratrol reduces the severity of NASH induced by MCD

	Control	MCD	MCD + R-L	MCD + R-M	MCD + R-H
Mice (In vivo)
Final body weight (g)	26.5 ± 1.6	13.7 ± 0.8^**	14.2 ± 0.8		15.2 ± 0.8
Liver weight (g)	1.1 ± 0.1	0.8 ± 0.1^*	0.7 ± 0.1		0.6 ± 0.1
Liver/body (%)	2.5 ± 0.3	9.5 ± 1.3^**	6.1 ± 0.4		5.3 ± 0.7^***
Liver TG (μg/mg Pro)	2.1 ± 0.3	10.3 ± 1.6^**	7.2 ± 0.8^***		3.6 ± 0.6^****
Serum ALT (U/L)	57.2 ± 8.3	174.1 ± 32.8^**	125.0 ± 21.7^***		96.4 ± 18.1^****
Liver TBARs (μmol/g Pro)	2.1 ± 0.3	10.3 ± 1.5^*	7.6 ± 0.9^***		5.21 ± 0.6^****
NAS score	2.0 ± 0.3	8.7 ± 1.2^*	7.0 ± 0.5^***		5.9 ± 0.4^****
Cell (In vitro)
ALT (U/L)	27.8 ± 3.8	78.9 ± 10.2^*	66.2 ± 8.7	49.1 ± 6.4^***	40.3 ± 6.5^****
AST (U/L)	34.6 ± 3.0	95.8 ± 11.3^*	83.7 ± 9.8	67.0 ± 7.3^***	52.9 ± 7.0^****
TBARs (μmol/g Pro)	13.1 ± 1.2	41.7 ± 5.8^**	37.4 ± 3.8	29.8 ± 2.8^***	20.5 ± 2.3^****
ROS	1.0 ± 0.2	5.6 ± 0.9^**	3.9 ± 0.57^***	2.7 ± 0.4^****	2.1 ± 0.4^****
TG (μg/mg Pro)	89.2 ± 8.5	276.3 ± 30.2^**	190.5 ± 21.0^***	143.1 ± 15.8^****	95.4 ± 9.7^****

Values are means ± SD, n = 10 (Serum and Liver) or n = 3 (Cell, three triplicate experiments)
R resveratrol, MCD methionine/choline-deficient diet or methionine/choline-deficient medium
In vivo, MCD + R-L (100 mg/kg), MCD + R-H (250 mg/kg)
In vitro, MCD + R-L (25 μmol/L), MCD + R-M (50 μmol/L), MCD + R-H (100 μmol/L)
^* P < 0.05, ^** P < 0.01 compared to Control
^*** P < 0.05, ^**** P < 0.01 compared to MCD