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Table 2 Effects of resveratrol on inflammatory cytokine levels in MCD-induced NASH

From: Resveratrol ameliorates hepatic steatosis and inflammation in methionine/choline-deficient diet-induced steatohepatitis through regulating autophagy

 

IL-1β

IL-6

TNF-α

 

Protein

mRNA

Protein

mRNA

Protein

mRNA

Serum or liver (In vivo)

 Control

24.7 ± 4.1

1.0 ± 0.3

19.2 ± 3.0

1.0 ± 0.3

31.8 ± 3.7

1.0 ± 0.3

 MCD

216.9 ± 35.8*

5.9 ± 1.7*

124.7 ± 18.3*

11.7 ± 2.8*

198.4 ± 27.9*

7.8 ± 1.9*

 MCD + R100

127.4 ± 15.4**

3.2 ± 0.8**

76.2 ± 7.7**

4.8 ± 1.2**

77.2 ± 8.15**

2.7 ± 0.7***

 MCD + R250

69.1 ± 9.3***

1.0 ± 0.3***

43.1 ± 3.6***

2.2 ± 0.5***

54.8 ± 5.14***

1.4 ± 0.4***

Cell (In vitro)

 Control

28.4 ± 3.07

1.0 ± 0.1

86.2 ± 6.4

1.0 ± 0.2

117.4 ± 11.6

1.0 ± 0.1

 MCD

86.9 ± 11.7*

2.8 ± 0.5*

278.5 ± 35.6*

5.4 ± 0.7*

786.5 ± 82.5*

9.1 ± 1.0*

 MCD + R25

60.5 ± 8.6**

2.2 ± 0.4

149.2 ± 17.3***

4.6 ± 0.4

445.7 ± 40.3**

5.8 ± 0.5**

 MCD + R50

47.2 ± 4.1***

1.7 ± 0.3**

124.7 ± 12.6***

3.3 ± 0.3**

360.1 ± 25.7***

3.6 ± 0.3***

 MCD + R100

41.9 ± 3.9***

1.3 ± 0.1***

117.4 ± 10.2***

1.7 ± 0.3***

279.6 ± 16.3***

1.4 ± 0.2***

  1. Values are means ± SD, n = 10 (serum) or n = 3 (medium, three triplicate experiments)
  2. MCD methionine/choline-deficient, R resveratrol
  3. * P < 0.01 compared to Control. ** P < 0.05, *** P < 0.01 compared to MCD