IL-1β | IL-6 | TNF-α | ||||
---|---|---|---|---|---|---|
Protein | mRNA | Protein | mRNA | Protein | mRNA | |
Serum or liver (In vivo) | ||||||
Control | 24.7 ± 4.1 | 1.0 ± 0.3 | 19.2 ± 3.0 | 1.0 ± 0.3 | 31.8 ± 3.7 | 1.0 ± 0.3 |
MCD | 216.9 ± 35.8* | 5.9 ± 1.7* | 124.7 ± 18.3* | 11.7 ± 2.8* | 198.4 ± 27.9* | 7.8 ± 1.9* |
MCD + R100 | 127.4 ± 15.4** | 3.2 ± 0.8** | 76.2 ± 7.7** | 4.8 ± 1.2** | 77.2 ± 8.15** | 2.7 ± 0.7*** |
MCD + R250 | 69.1 ± 9.3*** | 1.0 ± 0.3*** | 43.1 ± 3.6*** | 2.2 ± 0.5*** | 54.8 ± 5.14*** | 1.4 ± 0.4*** |
Cell (In vitro) | ||||||
Control | 28.4 ± 3.07 | 1.0 ± 0.1 | 86.2 ± 6.4 | 1.0 ± 0.2 | 117.4 ± 11.6 | 1.0 ± 0.1 |
MCD | 86.9 ± 11.7* | 2.8 ± 0.5* | 278.5 ± 35.6* | 5.4 ± 0.7* | 786.5 ± 82.5* | 9.1 ± 1.0* |
MCD + R25 | 60.5 ± 8.6** | 2.2 ± 0.4 | 149.2 ± 17.3*** | 4.6 ± 0.4 | 445.7 ± 40.3** | 5.8 ± 0.5** |
MCD + R50 | 47.2 ± 4.1*** | 1.7 ± 0.3** | 124.7 ± 12.6*** | 3.3 ± 0.3** | 360.1 ± 25.7*** | 3.6 ± 0.3*** |
MCD + R100 | 41.9 ± 3.9*** | 1.3 ± 0.1*** | 117.4 ± 10.2*** | 1.7 ± 0.3*** | 279.6 ± 16.3*** | 1.4 ± 0.2*** |