Comparative chemical profiling, cholinesterase inhibitions and anti-radicals properties of essential oils from Polygonum hydropiper L: A Preliminary anti- Alzheimer’s study

Table 2 Results of AChE and BChE inhibitory activity of essential oils from leaves and flowers of Polygonum hydropiper

Sample	% AChE inhibition Mean ± SEM (n = 3)			% BChE inhibition Mean ± SEM (n = 3)
Sample	Concentration	% inhibition	IC₅₀	Concentration	% inhibition	IC₅₀
Essential oils from leaves (Ph.Lo)	12.5	28.00 ± 0.57***	120	12.5	20.66 ± 1.20***	130
	25	36.50 ± 0.44***		25	31.00 ± 1.15***
	50	44.66 ± 1.20***		50	40.33 ± 0.88***
	100	52.00 ± 1.52***		100	48.66 ± 1.20***
	125	57.33 ± 0.88***		125	52.00 ± 0.57***
	250	63.66 ± 0.33***		250	61.00 ± 1.15***
	500	71.00 ± 0.57***		500	70.66 ± 0.88***
	1000	87.00 ± 1.15**		1000	82.66 ± 1.20***
Essential oils from flowers (Ph.Fo)	12.5	21.66 ± 0.66***	220	12.5	18.00 ± 0.57***	225
	25	28.00 ± 1.15***		25	23.00 ± 1.15***
	50	35.00 ± 0.57***		50	27.33 ± 0.33***
	100	43.33 ± 1.45***		100	35.00 ± 0.16***
	125	49.00 ± 0.00***		125	46.66 ± 1.20***
	250	55.00 ± 1.00***		250	53.66 ± 0.88***
	500	61.66 ± 1.20***		500	64.00 ± 0.00***
	1000	79.66 ± 0.88***		1000	77.50 ± 0.44***
Galanthamine (P. Control)	12.5	51.00 ± 0.00	15	12.5	60.00 ± 0.57	10
	25	60.50 ± 0.44		25	70.00 ± 1.52
	50	65.66 ± 0.33		50	77.66 ± 1.20
	100	72.00 ± 2.64		100	81.00 ± 0.00
	125	77.00 ± 0.00		125	86.66 ± 1.76
	250	83.33 ± 0.66		250	89.33 ± 1.45
	500	87.00 ± 1.20		500	92.33 ± 0.66
	1000	92.33 ± 0.33		1000	96.00 ± 1.52

Results were expressed as means ± S.E.M. The P values less than 0.05 were considered as statistically significant. Values significantly different when compared to slandered drug (Galanthamine) at the same concentration i.e. *: P < 0.05, **: P < 0.01 and ***: P < 0.001

ISSN: 1476-511X