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Table 1 Characteristics of study population by urinary albumin excretion status

From: Discordant associations of lipid parameters with albuminuria and chronic kidney disease: a population-based study

 

Normal urinary albumin excretion

Low-grade albuminuria

Increased urinary albumin excretion

P for trend

n ( % )

6817 (70.1)

2274 (23.4)

639 (6.6)

 

ACR (mg/g)

6.7 (5.0–8.4)

14.7 (12.5–19.0)*

53.3 (37.8–94.6)*#

<0.0001

Age (years)

55.5 ± 7.7

56.7 ± 8.4*

58.0 ± 9.6*#

< 0.0001

Male [n (%)]

2097 (30.8)

501 (22.0)

188 (29.4)

< 0.0001

BMI (kg/m2)

23.4 ± 3.2

24.0 ± 3.8*

24.7 ± 3.7*#

< 0.0001

WC (cm)

81.1 ± 9.2

82.3 ± 9.9*

85.1 ± 10.4*#

< 0.0001

SBP (mmHg)

124.2 ± 15.6

129.0 ± 16.9*

135.0 ± 18.9*#

< 0.0001

DBP (mmHg)

74.6 ± 9.5

76.4 ± 10.4*

78.9 ± 11.0*

< 0.0001

Current smoker [n (%)]

703 (10.6)

164 (7.4)*

74 (11.8) #

0.072

Current drinker [n (%)]

226 (3.4)

67 (3.1)

23 (3.7)

0.817

Physical activity (MET-h/week)

21.0 (10.5–45.0)

21.0 (10.5–42.0)

21.5 (10.5–42.0)

0.831

TG (mg/dL)

108.8 (79.6–157.5)

115.9 (82.3–169.9)*

137.2 (96.5–194.7)*#

< 0.0001

TC (mg/dL)

199.6 ± 47.4

203.6 ± 48.7*

202.4 ± 52.0

0.002

HDL-C (mg/dL)

51.2 ± 13.9

51.1 ± 13.8

47.8 ± 12.8*#

< 0.0001

LDL-C (mg/dL)

120.8 ± 36.5

122.2 ± 37.8

122.6 ± 39.0

0.067

Non-HDL-C (mg/dl)

148.4 ± 41.8

152.4 ± 43.2*

154.6 ± 46.3*

< 0.0001

Non-HDL-C/HDL-C

2.9 (2.3–3.6)

3.0 (2.4–3.8)*

3.3 (2.6–4.0)*#

< 0.0001

TG/HDL-C

2.2 (1.5–3.5)

2.3 (1.5–3.7)*

3.0 (1.9–4.5)*#

< 0.0001

FPG (mmol/L)

5.4 (5.0–5.9)

5.5 (5.0–6.1)*

5.6 (5.1–6.7)*#

< 0.0001

HbA1C (%)

6.0 ± 0.7

6.2 ± 1.0*

6.5 ± 1.5*#

< 0.0001

HOMA-IR

1.67 (1.19–2.39)

1.88 (1.29–2.80)*

2.23 (1.45–3.48)*#

< 0.0001

SCr (μmol/L)

67.0 (60.8–76.0)

65.0 (59.5–72.9)*

69.1 (60.9–81.1)*#

0.531

eGFR (ml/min per 1.73 m2)

110.9 (100.0–123.8)

111.5 (100.1–124.8)

106.4 (94.2–122.0)*#

< 0.0001

Previous CVD (%)

205 (3.0)

78 (3.4)

35 (5.5)*#

0.003

Previous hypertension (%)

893 (13.1)

486 (21.4)*

198 (31.0)*#

< 0.0001

Previous diabetes (%)

313 (4.6)

201 (8.8)*

90 (14.1)*#

< 0.0001

Previous dyslipidemia (%)

325 (4.8)

124 (5.5)

49 (7.7)*#

0.002

  1. 1. Data were means ± SD or medians (interquartile ranges) for skewed variables or numbers (proportions) for categorical variables.
  2. 2. P for trend was calculated for the linear regression analysis tests across the groups. P values were for the ANOVA or χ2 analyses across the groups.
  3. 3. *P < 0.05 compared with normal urinary albumin excretion group; #P < 0.05 compared with low-grade albuminuria group.
  4. 4. ACR, urinary albumin to creatinine ratio; BMI, body mass index; WC, waist circumference; SBP, systolic blood pressure; DBP, diastolic blood pressure; TG, triglycerides; TC, total cholesterol; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; FPG, fasting plasma glucose; HOMA-IR, homeostasis model assessment of insulin resistance; SCr, serum creatinine; eGFR, estimated glomerular filtration rate; CVD, cardiovascular diseases.