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Table 3 Association between lipid parameters and prevalent low-grade albuminuria, increased urinary albumin excretion and CKD

From: Discordant associations of lipid parameters with albuminuria and chronic kidney disease: a population-based study

   1-Quartile change of lipid parametersa
  Model 1 Model 2 Model 3 Model 4
Low-grade albuminuria TG 1.10 (1.06–1.15) 1.10 (1.06–1.15) 1.01 (0.96–1.06) 1.01 (0.97–1.06)
TC 1.06 (1.02–1.11) 1.03 (0.98–1.07) 1.01 (0.96–1.05) 1.02 (0.97–1.06)
HDL-C 1.00 (0.96–1.05) 1.05 (1.01–1.10) 0.99 (0.95–1.04) 0.99 (0.94–1.04)
LDL-C 1.02 (0.98–1.07) 0.99 (0.95–1.04) 0.97 (0.93–1.02) 0.98 (0.94–1.03)
Non-HDL-C 1.07 (1.03–1.12) 1.05 (1.00–1.09) 1.00 (0.96–1.05) 1.01 (0.96–1.06)
Non-HDL-C/HDL-C 1.08 (1.04–1.13) 1.10 (1.05–1.15) 1.01 (0.96–1.06) 1.01 (0.96–1.07)
TG/HDL-C 1.08 (1.03–1.12) 1.09 (1.05–1.14) 0.99 (0.94–1.04) 0.99 (0.94–1.04)
Increased urinary albumin excretion TG 1.36 (1.27–1.47) 1.34 (1.24–1.44) 1.16 (1.07–1.26) 1.17 (1.08–1.27)
TC 1.03 (0.96–1.11) 1.01 (0.94–1.08) 0.95 (0.88–1.02) 0.96 (0.89–1.04)
HDL-C 1.25 (1.16–1.35) 1.26 (1.17–1.36) 1.17 (1.08–1.27) 1.16 (1.07–1.26)
LDL-C 1.04 (0.97–1.12) 1.02 (0.95–1.09) 0.96 (0.89–1.04) 0.98 (0.91–1.06)
Non-HDL-C 1.12 (1.04–1.20) 1.09 (1.01–1.17) 0.99 (0.91–1.07) 1.00 (0.93–1.08)
Non-HDL-C/HDL-C 1.28 (1.19–1.38) 1.25 (1.16–1.35) 1.09 (1.00–1.18) 1.10 (1.01–1.19)
TG/HDL-C 1.42 (1.32–1.53) 1.40 (1.30–1.51) 1.21 (1.11–1.31) 1.21 (1.11–1.31)
CKD TG 1.38 (1.29–1.48) 1.35 (1.25–1.45) 1.18 (1.09–1.28) 1.19 (1.10–1.28)
TC 1.05 (0.98–1.13) 1.03 (0.96–1.10) 0.97 (0.90–1.05) 0.99 (0.92–1.07)
HDL-C 1.25 (1.16–1.34) 1.25 (1.16–1.34) 1.16 (1.07–1.25) 1.15 (1.06–1.24)
LDL-C 1.05 (0.98–1.13) 1.03 (0.96–1.10) 0.98 (0.91–1.05) 0.99 (0.92–1.07)
Non-HDL-C 1.15 (1.07–1.23) 1.11 (1.04–1.20) 1.02 (0.94–1.10) 1.03 (0.96–1.11)
Non-HDL-C/HDL-C 1.32 (1.23–1.41) 1.28 (1.19–1.37) 1.11 (1.03–1.20) 1.12 (1.04–1.22)
TG/HDL-C 1.42 (1.32–1.53) 1.39 (1.30–1.50) 1.21 (1.11–1.31) 1.21 (1.11–1.31)
  1. Data are odds ratios (95% confidence interval). Participants without low-grade albuminuria, increased urinary albumin excretion or CKD are defined as 0 and with low-grade albuminuria, increased urinary albumin excretion or CKD as 1
  2. Model 1 is unadjusted
  3. Model 2 is adjusted for age and sex
  4. Model 3 is further adjusted for BMI, current smoking and drinking status, physical activity level, SBP and HbA1c
  5. Model 4 is further adjusted for previously diagnosed diabetes, cardiovascular diseases, hypertension and dyslipidemia
  6. aAll variables were calculated for 1-Quartile increasing of lipid parameters except for HDL-C, which was calculated for 1-Quartile decreasing