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Table 3 Association between lipid parameters and prevalent low-grade albuminuria, increased urinary albumin excretion and CKD

From: Discordant associations of lipid parameters with albuminuria and chronic kidney disease: a population-based study

  

1-Quartile change of lipid parametersa

 

Model 1

Model 2

Model 3

Model 4

Low-grade albuminuria

TG

1.10 (1.06–1.15)

1.10 (1.06–1.15)

1.01 (0.96–1.06)

1.01 (0.97–1.06)

TC

1.06 (1.02–1.11)

1.03 (0.98–1.07)

1.01 (0.96–1.05)

1.02 (0.97–1.06)

HDL-C

1.00 (0.96–1.05)

1.05 (1.01–1.10)

0.99 (0.95–1.04)

0.99 (0.94–1.04)

LDL-C

1.02 (0.98–1.07)

0.99 (0.95–1.04)

0.97 (0.93–1.02)

0.98 (0.94–1.03)

Non-HDL-C

1.07 (1.03–1.12)

1.05 (1.00–1.09)

1.00 (0.96–1.05)

1.01 (0.96–1.06)

Non-HDL-C/HDL-C

1.08 (1.04–1.13)

1.10 (1.05–1.15)

1.01 (0.96–1.06)

1.01 (0.96–1.07)

TG/HDL-C

1.08 (1.03–1.12)

1.09 (1.05–1.14)

0.99 (0.94–1.04)

0.99 (0.94–1.04)

Increased urinary albumin excretion

TG

1.36 (1.27–1.47)

1.34 (1.24–1.44)

1.16 (1.07–1.26)

1.17 (1.08–1.27)

TC

1.03 (0.96–1.11)

1.01 (0.94–1.08)

0.95 (0.88–1.02)

0.96 (0.89–1.04)

HDL-C

1.25 (1.16–1.35)

1.26 (1.17–1.36)

1.17 (1.08–1.27)

1.16 (1.07–1.26)

LDL-C

1.04 (0.97–1.12)

1.02 (0.95–1.09)

0.96 (0.89–1.04)

0.98 (0.91–1.06)

Non-HDL-C

1.12 (1.04–1.20)

1.09 (1.01–1.17)

0.99 (0.91–1.07)

1.00 (0.93–1.08)

Non-HDL-C/HDL-C

1.28 (1.19–1.38)

1.25 (1.16–1.35)

1.09 (1.00–1.18)

1.10 (1.01–1.19)

TG/HDL-C

1.42 (1.32–1.53)

1.40 (1.30–1.51)

1.21 (1.11–1.31)

1.21 (1.11–1.31)

CKD

TG

1.38 (1.29–1.48)

1.35 (1.25–1.45)

1.18 (1.09–1.28)

1.19 (1.10–1.28)

TC

1.05 (0.98–1.13)

1.03 (0.96–1.10)

0.97 (0.90–1.05)

0.99 (0.92–1.07)

HDL-C

1.25 (1.16–1.34)

1.25 (1.16–1.34)

1.16 (1.07–1.25)

1.15 (1.06–1.24)

LDL-C

1.05 (0.98–1.13)

1.03 (0.96–1.10)

0.98 (0.91–1.05)

0.99 (0.92–1.07)

Non-HDL-C

1.15 (1.07–1.23)

1.11 (1.04–1.20)

1.02 (0.94–1.10)

1.03 (0.96–1.11)

Non-HDL-C/HDL-C

1.32 (1.23–1.41)

1.28 (1.19–1.37)

1.11 (1.03–1.20)

1.12 (1.04–1.22)

TG/HDL-C

1.42 (1.32–1.53)

1.39 (1.30–1.50)

1.21 (1.11–1.31)

1.21 (1.11–1.31)

  1. Data are odds ratios (95% confidence interval). Participants without low-grade albuminuria, increased urinary albumin excretion or CKD are defined as 0 and with low-grade albuminuria, increased urinary albumin excretion or CKD as 1
  2. Model 1 is unadjusted
  3. Model 2 is adjusted for age and sex
  4. Model 3 is further adjusted for BMI, current smoking and drinking status, physical activity level, SBP and HbA1c
  5. Model 4 is further adjusted for previously diagnosed diabetes, cardiovascular diseases, hypertension and dyslipidemia
  6. aAll variables were calculated for 1-Quartile increasing of lipid parameters except for HDL-C, which was calculated for 1-Quartile decreasing