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Table 3 Summary of meta-analysis of association of PCSK9 E670G polymorphism and CAD risk

From: The associations between proprotein convertase subtilisin/kexin type 9 E670G polymorphism and the risk of coronary artery disease and serum lipid levels: a meta-analysis

 

N

n (CAD/controls)

Dominant model

Allelic model

 

OR (95 % CI)

POR

I 2 (%)

PQ

OR (95 % CI)

POR

I 2 (%)

PQ

All

9

1517/1795

1.601 (1.314–1.951)

<0.001

30.4

0.175

1.546 (1.301–1.838)

<0.001

36.3

0.128

Ethnicity

 Asians

7

1215/1455

1.590 (1.278–1.978)

<0.001

44.0

0.098

1.503 (1.244–1.816)

<0.001

45.5

0.088

 non-Asians

2

302/340

1.652 (1.040–2.626)

0.034

0.0

0.386

1.788 (1.166–2.743)

0.008

0

0.318

HWE

  P > 0.05

7

1397/1675

1.633 (1.321–2.018)

<0.01

41.7

0.11

1.627 (1.335–1.983)

<0.001

43.6

0.100

  P < 0.05

2

120/120

1.411 (0.819–2.430)

0.215

0

0.327

1.306 (0.912–1.869)

0.145

0

0.360

  1. OR odds ratio, CI confidence interval, P OR p values for odds ratio, P Q p values for heterogeneity form Q-test, HWE Hardy-Weinberg equilibrium, N number of study, n number of individuals
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Lipids in Health and Disease

ISSN: 1476-511X