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Table 3 Summary of meta-analysis of association of PCSK9 E670G polymorphism and CAD risk

From: The associations between proprotein convertase subtilisin/kexin type 9 E670G polymorphism and the risk of coronary artery disease and serum lipid levels: a meta-analysis

  N n (CAD/controls) Dominant model Allelic model
  OR (95 % CI) POR I 2 (%) PQ OR (95 % CI) POR I 2 (%) PQ
All 9 1517/1795 1.601 (1.314–1.951) <0.001 30.4 0.175 1.546 (1.301–1.838) <0.001 36.3 0.128
Ethnicity
 Asians 7 1215/1455 1.590 (1.278–1.978) <0.001 44.0 0.098 1.503 (1.244–1.816) <0.001 45.5 0.088
 non-Asians 2 302/340 1.652 (1.040–2.626) 0.034 0.0 0.386 1.788 (1.166–2.743) 0.008 0 0.318
HWE
P > 0.05 7 1397/1675 1.633 (1.321–2.018) <0.01 41.7 0.11 1.627 (1.335–1.983) <0.001 43.6 0.100
P < 0.05 2 120/120 1.411 (0.819–2.430) 0.215 0 0.327 1.306 (0.912–1.869) 0.145 0 0.360
  1. OR odds ratio, CI confidence interval, P OR p values for odds ratio, P Q p values for heterogeneity form Q-test, HWE Hardy-Weinberg equilibrium, N number of study, n number of individuals