Skip to main content

Table 4 Summary of meta-analysis of association of PCSK9 E670G polymorphism and lipid levels

From: The associations between proprotein convertase subtilisin/kexin type 9 E670G polymorphism and the risk of coronary artery disease and serum lipid levels: a meta-analysis

 

TC

TG

HDL-C

LDL-C

Group and subgroups

N/n

SMD (95 % CI)

P

I 2 (%)

PQ

N/n

SMD (95 % CI)

P

I 2 (%)

PQ

N/n

SMD (95 % CI)

P

I 2 (%)

PQ

N/n

SMD (95 % CI)

P

I 2 (%)

PQ

All

22/13933

0.126 (0.023–0.229)

0.016

57.4

<0.001

20/6982

0.031 (−0.048–0.110)

0.440

28.6

0.114

21/8147

−0.123 (−0.251-0.006)

0.061

63.7

<0.001

23/14252

0.170 (0.053–0.287)

0.004

68.2

<0.001

Ethnicity

 Asian

11/3813

0.133 (−0.067–0.334)

0.193

67.3

<0.001

11/3813

0.075 (−0.031–0.180)

0.164

12.6

0.325

11/3813

−0.224 (−0.423–−0.025)

0.027

66.5

0.001

11/3813

0.286 (0.021–0.551)

0.034

81.4

<0.001

 non-Asian

11/10120

0.126 (0.014–0.238)

0.027

46.5

0.044

9/3169

−0.024 (−0.142–0.094)

0.688

41.5

0.090

104234

−0.017 (−0.165–0.132)

0.825

48.5

0.042

12/10439

0.097 (0.011–0.184)

0.027

18.8

0.259

Type of study

 Cohort

13/11668

0.133 (0.010–0.256)

0.034

53.9

0.011

9/4411

−0.097 (−0.222–0.029)

0.132

14.4

0.31

10/5476

0.050 (−0.053–0.153)

0.342

0.0

0.883

14/11987

0.100 (0.004–0.197)

0.042

31.7

0.122

 C-C

9/2265

0.119 (−0.077–0.315)

0.235

65.4

0.003

11/2571

0.113 (0.012–0.214)

0.028

7.1

0.376

11/2571

−0.257 (−0.467–−0.048)

0.016

74.3

<0.001

9/2265

0.307 (0.027–0.588)

0.031

83.3

<0.001

  1. C-C case–control, SMD standardized mean difference, CI confidence interval, P OR p values for odds ratio, P Q p values for heterogeneity form Q-test, TC total cholesterol, TG triglyceride, HDL-C high density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, N number of study, n number of individuals