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Table 4 Summary of meta-analysis of association of PCSK9 E670G polymorphism and lipid levels

From: The associations between proprotein convertase subtilisin/kexin type 9 E670G polymorphism and the risk of coronary artery disease and serum lipid levels: a meta-analysis

  TC TG HDL-C LDL-C
Group and subgroups N/n SMD (95 % CI) P I 2 (%) PQ N/n SMD (95 % CI) P I 2 (%) PQ N/n SMD (95 % CI) P I 2 (%) PQ N/n SMD (95 % CI) P I 2 (%) PQ
All 22/13933 0.126 (0.023–0.229) 0.016 57.4 <0.001 20/6982 0.031 (−0.048–0.110) 0.440 28.6 0.114 21/8147 −0.123 (−0.251-0.006) 0.061 63.7 <0.001 23/14252 0.170 (0.053–0.287) 0.004 68.2 <0.001
Ethnicity
 Asian 11/3813 0.133 (−0.067–0.334) 0.193 67.3 <0.001 11/3813 0.075 (−0.031–0.180) 0.164 12.6 0.325 11/3813 −0.224 (−0.423–−0.025) 0.027 66.5 0.001 11/3813 0.286 (0.021–0.551) 0.034 81.4 <0.001
 non-Asian 11/10120 0.126 (0.014–0.238) 0.027 46.5 0.044 9/3169 −0.024 (−0.142–0.094) 0.688 41.5 0.090 104234 −0.017 (−0.165–0.132) 0.825 48.5 0.042 12/10439 0.097 (0.011–0.184) 0.027 18.8 0.259
Type of study
 Cohort 13/11668 0.133 (0.010–0.256) 0.034 53.9 0.011 9/4411 −0.097 (−0.222–0.029) 0.132 14.4 0.31 10/5476 0.050 (−0.053–0.153) 0.342 0.0 0.883 14/11987 0.100 (0.004–0.197) 0.042 31.7 0.122
 C-C 9/2265 0.119 (−0.077–0.315) 0.235 65.4 0.003 11/2571 0.113 (0.012–0.214) 0.028 7.1 0.376 11/2571 −0.257 (−0.467–−0.048) 0.016 74.3 <0.001 9/2265 0.307 (0.027–0.588) 0.031 83.3 <0.001
  1. C-C case–control, SMD standardized mean difference, CI confidence interval, P OR p values for odds ratio, P Q p values for heterogeneity form Q-test, TC total cholesterol, TG triglyceride, HDL-C high density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, N number of study, n number of individuals