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Table 1 Main characteristics of the studies included in the meta-analysis examining the relationship between adiponectin expression and survival in patients with various types of cancer

From: Adiponectin is associated with poor prognosis in carcinoma patients: evidence from a meta-analysis

Study Country Patient number Races St-age Follow-up(m) Detected methoda Cut-off value Tumor type Survival analysis Source of HR Analytic method
Wang 2014 [6] China 85 Asian I ~ IV NA IHC Low:- ~ + High:++ ~ +++b HCC OS SC U
Siegel 2014 [7] America 140 Non- Asian A ~ Cc Median 8 RIA Low:<median
(13,050 ng/ml)
High:≥median
HCC OS Report M
Cubukcu 2014 [10] Turkey 38 Non- Asian I ~ III Median 30 IHC Negative: No cells stained
Positive:>0 % of cells stained
BC OS, DFS Report M
Canhoroz 2014 [24] Turkey 53 Non- Asian II ~ III Mean 41 IHC Negative:<5 % of cells stained
Positive:≥5 % of cells stained
CRC OS, DFS SC U
Lee 2014 [9] Korea 247 Asian I ~ IV Median 50.4 ELISA Low:< 8.0 ng/ml
High:≥11.8 ng/ml
BC DFS Reportd M
Shin 2014 [8] Korea 75 Asian I ~ IV Mean 82.5 IHC Negative: No cells stained
Positive:>0 % of cells stained
HCC OS, DFS Report (OS);
SC (DFS)
M
Kerenidi 2013 [11] Greece 80 Non- Asian I ~ IV NA RIA Low:<median
(14.39 ng/ml)
High:≥median
LC OS Report U
Tsukada 2011 [12] Japan 100 Asian I ~ IV NA ELISA Low: < 7 ug/ml
High:≥7 ug/ml
GC OS SC U
Petridou 2009 [13] Greece 121 Non- Asian I ~ IV Median 74.3 RIA Low:<5.94 ug/ml
High:≥5.94ug/ml
NHL DFS, OS Report M
Ferroni 2007 [25] Italy 60 Non- Asian A ~ Ce Median 37 EIA Low:<6.39 ug/ml
High:≥6.39ug/ml
CRC DFS SC U
  1. BC, breast cancer; CRC, colorectal cancer; HCC, hepatocellular carcinoma; GC, gastric carcinoma; LC, lung cancer; NHL, non-Hodgkin’s lymphoma; EIA, enzyme immunoassay; ELISA, enzyme-linked immunosorbent assay; RIA, radioimmunoassay; IHC, immunohistochemistry; DFS, disease-free survival; OS overall survival; SC, survival curves; U, univariate, M, multivariate; HR, hazard ratio; NA, not available
  2. aDetected specimens of IHC was tumor tissue, all other specimens were serum
  3. bSemiquantitative scoring system
  4. cBarcelona Clinic Liver Cancer stage
  5. dHRs and 95%CIs of the top Tertile vs. the bottom Tertile
  6. eDukes’ stage