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Table 1 Main characteristics of the studies included in the meta-analysis examining the relationship between adiponectin expression and survival in patients with various types of cancer

From: Adiponectin is associated with poor prognosis in carcinoma patients: evidence from a meta-analysis

Study

Country

Patient number

Races

St-age

Follow-up(m)

Detected methoda

Cut-off value

Tumor type

Survival analysis

Source of HR

Analytic method

Wang 2014 [6]

China

85

Asian

I ~ IV

NA

IHC

Low:- ~ + High:++ ~ +++b

HCC

OS

SC

U

Siegel 2014 [7]

America

140

Non- Asian

A ~ Cc

Median 8

RIA

Low:<median

(13,050 ng/ml)

High:≥median

HCC

OS

Report

M

Cubukcu 2014 [10]

Turkey

38

Non- Asian

I ~ III

Median 30

IHC

Negative: No cells stained

Positive:>0 % of cells stained

BC

OS, DFS

Report

M

Canhoroz 2014 [24]

Turkey

53

Non- Asian

II ~ III

Mean 41

IHC

Negative:<5 % of cells stained

Positive:≥5 % of cells stained

CRC

OS, DFS

SC

U

Lee 2014 [9]

Korea

247

Asian

I ~ IV

Median 50.4

ELISA

Low:< 8.0 ng/ml

High:≥11.8 ng/ml

BC

DFS

Reportd

M

Shin 2014 [8]

Korea

75

Asian

I ~ IV

Mean 82.5

IHC

Negative: No cells stained

Positive:>0 % of cells stained

HCC

OS, DFS

Report (OS);

SC (DFS)

M

Kerenidi 2013 [11]

Greece

80

Non- Asian

I ~ IV

NA

RIA

Low:<median

(14.39 ng/ml)

High:≥median

LC

OS

Report

U

Tsukada 2011 [12]

Japan

100

Asian

I ~ IV

NA

ELISA

Low: < 7 ug/ml

High:≥7 ug/ml

GC

OS

SC

U

Petridou 2009 [13]

Greece

121

Non- Asian

I ~ IV

Median 74.3

RIA

Low:<5.94 ug/ml

High:≥5.94ug/ml

NHL

DFS, OS

Report

M

Ferroni 2007 [25]

Italy

60

Non- Asian

A ~ Ce

Median 37

EIA

Low:<6.39 ug/ml

High:≥6.39ug/ml

CRC

DFS

SC

U

  1. BC, breast cancer; CRC, colorectal cancer; HCC, hepatocellular carcinoma; GC, gastric carcinoma; LC, lung cancer; NHL, non-Hodgkin’s lymphoma; EIA, enzyme immunoassay; ELISA, enzyme-linked immunosorbent assay; RIA, radioimmunoassay; IHC, immunohistochemistry; DFS, disease-free survival; OS overall survival; SC, survival curves; U, univariate, M, multivariate; HR, hazard ratio; NA, not available
  2. aDetected specimens of IHC was tumor tissue, all other specimens were serum
  3. bSemiquantitative scoring system
  4. cBarcelona Clinic Liver Cancer stage
  5. dHRs and 95%CIs of the top Tertile vs. the bottom Tertile
  6. eDukes’ stage