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Table 2 CETP expression has no effect on glucose tolerance in aged, hypertriglyceridemic or hypercholesterolemic mice

From: Cholesteryl Ester Transfer Protein (CETP) expression does not affect glucose homeostasis and insulin secretion: studies in human CETP transgenic mice

Model

AUC ± SE

n

(mg.dl−1.min)

male/female

Aged-NTg

10933 ± 1570 (4)

4/0

Aged-CETP

11737 ± 1069 (7)

7/0

ApoCIII−/+

22777 ± 3238 (4)

3/1

ApoCIII−/+ /CETP−/+

25114 ± 9466 (3)

1/2

LDLr−/+

15920 ± 2587 (4)

0/4

LDLr−/+/CETP+/−

12951 ± 407 (5)

2/3

  1. Area under the curve (AUC) of oral glucose tolerance test in aged (18 month old), apo CIII transgenic and LDL receptor deficient (LDLr−/+) mice expressing or not CETP, fasted for 12 h. At time zero, mice received a glucose dose of 1.5 g/kg body weight by gavage. Samples for glucose determination were collected from the tail tip at 0, 15, 30, 60 and 120 min. Values are expressed as mean ± SE (n: male and female pooled data). Student’s t test for all comparisons: non-significant
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Lipids in Health and Disease

ISSN: 1476-511X