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Table 3 N-3 PUFA improved hepatic lipid metabolism in FOH group.

From: Fish oil alleviated high-fat diet–induced non-alcoholic fatty liver disease via regulating hepatic lipids metabolism and metaflammation: a transcriptomic study

Category/Function

Gene symbol / Gene alias

Gene name

Fold change

WDvs. CON

FOH vs. WD

Fatty Acid Transport

Slc27a1/FATP-1

solute carrier family 27 (fatty acid transporter), member1

1.48 ↑

0.85↓

Slc27a2/ FATP-2

solute carrier family 27 (fatty acid transporter), member 2

1.17 ↑

1.40↑

Cd36

fatty acid translocase (FAT/CD36)

1.05↓

2.07↑

Fatty Acid Synthesis

Srebf1/SREBP1c

sterol regulatory element binding transcription factor 1

1.72↑

2.27↓

Fasn

fatty acid synthase

8.54↓

1.99↓

Acaca

acetyl-CoA carboxylase alpha

3.10↓

1.17↑

Elovl5

ELOVL fatty acid elongase 5

1.31↓

2.26↓

Fads1

fatty acid desaturase 1

6.28↓

2.87↓

Fads2

fatty acid desaturase 2

3.26↓

2.32↓

Scd1

stearoyl-Coenzyme A desaturase 1

1.49↓

2.64↓

Fatty Acid Degradation

Ppara/PPARα

peroxisome proliferator activated receptor alpha

1.48↓

1.31 ↑

Cpt1a

carnitine palmitoyltransferase 1a, liver

1.08↑

1.53↑

Cpt2

carnitine palmitoyltransferase 2

1.01↑

1.42↑

VLDL Secretion

Mttp

microsomal triglyceride transfer protein

1.29↓

1.23↑

Apob

apolipoprotein B

1.11↓

1.26↑