Table 4 N-3 PUFA improved hepatic cholesterol homeostasis in FOH group

Cholesterol synthesis

Pmvk

phosphomevalonate kinase

2.9 ↓

1.22 ↓

Fdps

farnesyl diphosphate synthase

6.97 ↓

1.66 ↓

Nsdhl

NAD(P) dependent steroid dehydrogenase-like

1.95 ↓

1.41 ↓

Dhcr7

7-dehydrocholesterol reductase

3.13 ↓

1.22 ↓

Cholesterol-rich lipoprotein uptake

Ldlr

LDL receptor

2.56 ↓

1.13 ↑

Olr1/LOX-1

oxidized low density lipoprotein (lectin-like) receptor 1

60.48 ↑

6.70 ↓

Scarb1/ SR-BI

Scavenger receptor class B type I (SR-BI)

1.10 ↑

1.37 ↓

CD36

Cluster differentiation protein 36

1.05 ↓

2.07 ↑

Cholesterol secretion

Abcg1

ATP-binding cassette, subfamily G (WHITE), member 1

3.57 ↑

1.54↑

Abcg5

ATP-binding cassette, subfamily G (WHITE), member 5

1.48 ↓

1.93↑

Abcg8

ATP-binding cassette, subfamily G (WHITE), member 8

7.24 ↓

2.7 1↑

Intracellular metabolism to oxysterols and bile acids

Cyp7a1

cytochrome P450, family 7, subfamily a, polypeptide 1

1.53 ↓

1.98↑

Cyp27a1

cytochrome P450, family 27, subfamily a, polypeptide 1

1.14 ↓

1.08↑