Table 5 N-3 PUFA reduced liver inflammation in FOH group

CD family

Cd8a

CD8 antigen, alpha polypeptide (p32)

2.53 ↑

1.78 ↓

Cd44

CD44 antigen

3.37 ↑

1.66 ↓

Cd81/TAPA-1

CD81 antigen; target of antiproliferative antibody 1

1.17 ↑

1.08 ↓

Cd180

CD180 antigen

1.55 ↑

1.14 ↓

Chemokines and chemokine receptors

Ccl2/MCP-1

chemokine (C-C motif) ligand 2; monocyte chemoattractant protein 1

5.73 ↑

2.12 ↓

Cxcl1/GROa

chemokine (C-X-C motif) ligand 1; growth-regulated oncogene, alpha

5.26 ↑

3.92 ↓

Cxcl9/MIG

chemokine (C-X-C motif) ligand 9; monokine induced by interferon-gamma

1.38 ↑

2.10 ↓

Cxcl16

chemokine (C-X-C motif) ligand 16

3.25 ↑

1.66 ↓

Cxcr3

chemokine (C-X-C motif) receptor 3

2.24 ↑

1.29 ↓

Cxcr4

chemokine (C-X-C motif) receptor 4

1.75 ↑

1.58 ↓

Semaphorins, plexins and neuropilins

Sema4a

sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A

1.87 ↑

1.29 ↓

Sema4d

sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D

2.30 ↑

1.29 ↓

Sema6b

sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B

2.29 ↑

1.27 ↓

Plxnd1

plexin D1

1.38 ↑

1.10 ↓

JAK-STAT-SOCS pathway

Jak2

Janus kinase 2 (a protein tyrosine kinase)

1.23 ↑

1.05 ↓

Jak3

Janus kinase 3 (a protein tyrosine kinase, leukocyte)

1.95 ↑

1.09 ↓

Stat3

signal transducer and activator of transcription 3 (acute-phase response factor)

1.40 ↑

1.33 ↓

Stat5b

signal transducer and activator of transcription 5B

1.48 ↑

1.33 ↓

Socs1

suppressor of cytokine signaling 1

5.09 ↑

7.06 ↓

Socs2

suppressor of cytokine signaling 2

3.46 ↑

1.39 ↓

IFN pathway

Irf1

interferon regulatory factor 1

2.07 ↑

1.40 ↓

Irf5

interferon regulatory factor 5

1.71 ↑

1.18 ↓

TNFα and TGFβ pathways

Ltb

lymphotoxin beta (TNF superfamily, member 3)

1.99 ↑

2.19 ↓

Tnfrsf14

tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)

3.99 ↑

1.70 ↓

Tnfrsf1b

tumor necrosis factor receptor superfamily, member 1B

1.56 ↑

1.07 ↓

Traf7

TNF receptor-associated factor 7

1.94 ↑

1.67 ↓

Tgfb1

transforming growth factor, beta 1

2.31 ↑

1.02 ↓

Tgfbr2

transforming growth factor, beta receptor II (70/80 kDa)

1.30 ↑

1.21 ↓

NFκB pathway

Ikbkb

inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta

1.21 ↑

1.05 ↓

Nfkb1

nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105)

1.45 ↑

1.19 ↓

Nfkb2

nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)

1.95 ↑

1.33 ↓

Toll-like receptors and lipopolysaccharide signaling pathway

Tlr2

toll-like receptor 2

1.86 ↑

1.02 ↓

Cd14

CD14 antigen (lipopolysaccharide receptor)

1.50 ↑

1.16 ↓

Litaf

lipopolysaccharide-induced TNF factor

2.47 ↑

1.54 ↓

Matrix proteases

Mmp9

matrix metallopeptidase 9 (gelatinase B, 92 kDa gelatinase, 92 kDa type IV collagenase)

6.03 ↑

2.05 ↓

Mmp14

matrix metallopeptidase 14 (membrane-inserted)

1.30 ↑

1.02 ↓

Plat/tPA

plasminogen activator, tissue

2.15 ↑

1.53 ↓

Plau/uPA

plasminogen activator, urokinase

1.50 ↑

1.66 ↓