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Table 4 Plasma fatty acid composition in control and TTP-treated micea

From: Tetradecylthiopropionic acid induces hepatic mitochondrial dysfunction and steatosis, accompanied by increased plasma homocysteine in mice

 

Diet groups

Fatty acid (wt %)

Control

0.3 % TTP

0.6 % TTP

0.9 % TTP

Σ SFAs

32.1 ± 1.5

31.8 ± 0.9

31.2 ± 0.6

30.9 ± 0.6

Σ MUFAs

22.7 ± 2.2

20.6 ± 3.1

23.8 ± 4.8

22.2 ± 2.4

Σ n-6 PUFAs

36.9 ± 1.1

37.8 ± 2.1

35.0 ± 3.9

36.7 ± 2.1

C22:5n-6

0.29 ± 0.05

0.16 ± 0.04***

0.14 ± 0.06***

0.14 ± 0.04***

Σ n-3 PUFAs

7.8 ± 0.5

9.2 ± 0.8*

8.9 ± 1.7

8.7 ± 0.4

C20:5n-3

0.53 ± 0.07

0.62 ± 0.06

0.69 ± 0.22

0.70 ± 0.16

C22:5n-3

0.24 ± 0.03

0.31 ± 0.04

0.32 ± 0.11

0.33 ± 0.09

C22:6n-3

6.6 ± 0.5

7.7 ± 0.9

7.3 ± 1.4

7.2 ± 0.4

Σ n-3 PUFA/Σ n-6 PUFA ratiob

0.21 ± 0.02

0.24 ± 0.02*

0.25 ± 0.03**

0.24 ± 0.01*

  1. Abbreviations: SFAs saturated fatty acids; MUFAs monounsaturated fatty acids; PUFAs polyunsaturated fatty acids; TTP tetradecylthiopropionic acid
  2. aMeans with standard deviation are shown (n = 7–8), and results were analyzed by one-way ANOVA with Dunnett’s post hoc test (P* < 0.05, P** < 0.01, P*** < 0.001)n-3
  3. bPUFA/n-6 PUFA calculated as: (18:4n-3 + 18:3n-3 + 20:3n-3 + 20:4n-3 + 21:5n-3 + 22:6n-3 + 22:5n-3)/(18:3n-6 + 18:2n-6 + 20:4n-6 + 20:3n-6 + 20:2n-6 + 22:5n-6 + 22:4n-6 + 22:2n-6)
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Lipids in Health and Disease

ISSN: 1476-511X