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Fig. 2 | Lipids in Health and Disease

Fig. 2

From: Serum CETP status is independently associated with reduction rates in LDL-C in pitavastatin-treated diabetic patients and possible involvement of LXR in its association

Fig. 2

T0901317 increased CETP and SREBP-1c mRNA levels, and decreased ApoA-I mRNA levels in HepG2 cells. HepG2 cells grown to semi-confluence were treated with DMEM containing 0 (control), 1, or 10 μM T0901317 for 24 h. TaqMan real-time PCR was performed for CETP (a), SREBP-1c (a), ApoA-I (b), and β-actin. Results were the mean ± SD of three to five independent experiments in triplicate (n = 9–15). *P < 0.05 and **P < 0.01 significantly different from cells under the indicated conditions, according to an unpaired t-test for Fig. 2a and ANOVA with Scheffé’s post hoc test for Fig. 2b Footnote: The inhibitory effect of T0901317 on ApoA-I expression was relatively weak and thus the concentrations of 1 and 10 μM were used in order to show a considerable reduction of ApoA-I expression

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Lipids in Health and Disease

ISSN: 1476-511X