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Fig. 3 | Lipids in Health and Disease

Fig. 3

From: Serum CETP status is independently associated with reduction rates in LDL-C in pitavastatin-treated diabetic patients and possible involvement of LXR in its association

Fig. 3

LXR silencing inhibited T0901317-stimulated CETP expression in HepG2 cells. HepG2 cells (30–40 % confluence) were transfected with negative control siRNA or siRNA against LXR-α (a and b) or LXR-β (c and d) (25nM each). After a 48-h incubation, HepG2 cells that had been refreshed with DMEM were treated with or without T0901317 (500 nM) for an additional 24 h (b and d). Protein amounts of LXR-α (a), LXR-β (c), and β-actin in the cell lysates were determined by immunoblot analyses. Results were the mean ± SD of an independent experiment in triplicate or quadruplicate (n = 3-4). NS, not significant; *P < 0.05 and **P < 0.01 significantly different from cells under the indicated conditions, according to an unpaired t-test for Fig. 3a and c and ANOVA with Scheffé’s post hoc test for Fig. 3b and d

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Lipids in Health and Disease

ISSN: 1476-511X