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Table 3 Linear regression analyses of baseline values and percent changes in clinical factors affecting the percent change in LDL-C levels

From: Serum CETP status is independently associated with reduction rates in LDL-C in pitavastatin-treated diabetic patients and possible involvement of LXR in its association

 

Univariate

Multivariate

n

βa

95 % CIb

p

n

βc

95 % CIb

p

BMI (kg/m2)

46

0.17

−0.39 ~ 1.39

0.27d

    

Gender (Male = 1, Female = 2)

47

−0.13

−11.5 ~ 4.59

0.39

    

Age (year)

47

−0.24

−0.72 ~ 0.06

<0. 1

44

−0.07

−0.55 ~ 0.38

0.7

Body weight (kg)

47

0.3

0.02 ~ 0.52

0.04

44

0.07

−0.24 ~ 0.36

0.68

Abdominal girth (cm)

45

0.11

−0.28 ~ 0.59

0.47

    

HbA1c (%)

47

0.08

−3.57 ~ 6.38

0.57

    

Uric acid (mg/dL)

47

0.05

−2.3 ~ 3.26

0.74

    

TC (mg/dL)

47

−0.37

−0.29 ~ −0.04

0.011

44

-0.39

−0.30 ~ −0.05

0.009

LDL-C (mg/dL)

47

−0.21

−0.22 ~ 0.04

0.15e

    

TG (mg/dL)

47

−0.1

−0.07 ~ 0.04

0.5

    

HDL-C (mg/dL)

47

−0.32

−0.56 ~ −0.03

0.03

44

−0.16

−0.42 ~ 0.13

0.29

sd LDL-C (mg/dL)

47

−0.29

−0.43 ~ 0.01

0.04e

    

ApoA-I (mg/dL)

47

−0.28

−0.29 ~ 0.003

0.05f

    

CETP (μg/mL)

44

0.38

2.09 ~ 15.69

0.01

44

0.41

2.91 ~ 16.5

0.006

Pioglitazone use

47

−0.02

−12.1 ~ 10.63

0.9

    

Change in Body weight (%)

47

0.19

−0.57 ~ 2.66

0.2

43

0.36

0.44 ~ 3.64

0.01

Change in HbA1c (%)

47

−0.009

−0.56 ~ 0.52

0.95

    

Change in Uric acid (%)

47

0.14

−0.15 ~ 0.43

0.33

    

Change in TG (%)

46

0.22

−0.02 ~ 0.12

0.15

43

0.17

−0.02 ~ 0.10

0.2

Change in HDL-C (%)

47

−0.07

−0.47 ~ 0.29

0.64

    

Change in ApoA-I (%)

46

0.06

−0.48 ~ 0.71

0.71

    

Change in CETP (%)

44

0.44

0.12 ~ 0.52

0.003

43

0.57

0.21 ~ 0.60

0.0001

  1. astandard regression coefficient
  2. bconfidence interval
  3. cstandard partial regression coefficient
  4. dBMI was excluded from multivariate analysis, since colinearity between BMI and body weight was found
  5. eLDL-C and sd LDL-C were excluded from multivariate analysis, since colinearity among TC, LDL-C and sd LDL-C was found
  6. fApoA-I was excluded from multivariate analysis, since colinearity between HDL-C and ApoA-I was found