SNPs in FNDC5 (irisin) are associated with obesity and modulation of glucose and lipid metabolism in Saudi subjects

Table 3 Genotype distribution in obese vs Non-obese subjects

	Obese (%)	Non-obese (%)	Odds ratio (95 CI)	P-value
rs3480 A/G
GG	49 (17.2)	66 (25.8)	0.48 (0.28–0.79)	0.005
AG	136 (47.7)	117 (45.7)	0.76 (0.50–1.15)	0.20
AA	100 (35.1)	73 (28.5)	1.0	1.0
rs1746661 G/T
TT	22 (8.7)	18 (7.0)	1.30 (0.64–2.6)	0.47
GT	83 (32.7)	83 (32.4)	1.04 (0.69–1.56)	0.82
GG	149 (59.7)	155 (60.5)	1.0	1.0
rs1298190 A/G
GG	5 (1.8)	3 (1.2)	1.25 (0.26–6.0)	0.77
AG	64 (22.5)	63 (24.5)	0.88 (0.58–1.35)	0.57
AA	216 (75.8	191 (74.3)	1.0	1.0
rs1570569 G/T
TT	19 (6.6)	13 (5.1)	1.33 (0.60–2.92)	0.47
GT	100 (35)	89 (34.8)	1.06 (0.72–1.56)	0.74
GG	167 (58.4)	154 (60.2)	1.0	1.0

Note: The genotype distribution of rs3480 (A/G), rs1746661 (G/T), rs1298190 (A/G) and rs1570569 (G/T) variants of FNDC5 gene. Genotype frequency differences between obese and non-obese were tested for each SNP using Chi-square test. Odds ratios (ORs) and 95 % confidence intervals for genotypes were calculated using multinomial logistic regression analyses using obesity as dependent variable adjusted for age, gender and T2DM. Significance was set at p < 0.05. The most common genotype was used as the reference. The variant rs7246344 (A/G) was excluded from analysis due to low rare genotype frequency
Bold means reference value

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