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Table 5 Haplotype frequency of FNDC5 variants in T2DM versus non-T2DM and obese versus lean subjects

From: SNPs in FNDC5 (irisin) are associated with obesity and modulation of glucose and lipid metabolism in Saudi subjects

Haplotype T2DM Control Odd ratio (95 % CI) P-value Obese Lean Odd ratio (95 % CI) P-value
AGAAG 119 125 1.00 (Reference) 95 73 1.00 (Reference)
AGAGG 87 99 0.93 (0.63–1.35) 0.681 65 61 0.82 (0.52–1.30) 0.398
GGAAG 27 28 1.01 (0.56–1.82) 0.966 8 27 0.23 (0.10–0.53) 0.001
GGAGG 9 14 0.68 (0.28–1.62) 0.379 11 6 1.41 (0.50–3.99) 0.519
GGGAG 45 50 0.95 (0.59–1.52) 0.817 32 32 0.77 (0.43–1.37) 0.371
GTAAT 39 45 0.91 (0.55–1.50) 0.711 33 27 0.94 (0.52–1.70) 0.836
GTAGT 47 39 1.27 (0.77–2.07) 0.349 29 30 0.74 (0.41–1.35) 0.327
GTGAG 3 5 0.63 (0.15–2.69) 0.533 4 3 1.02 (0.22–4.72) 0.975
  1. Note: Order of SNPs: rs3480A/G, rs1746661G/T, rs1298190A/G, rs726344A/G and rs1570569G/T). Pearson’s p value and OR (95 % CI) were calculated by haplotype analysis
  2. Bold means significant