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Table 3 Principal Component analysis (PCA); the association between tumor characteristics and lipoprotein subfractions by NMR

From: Lipoprotein subfractions by nuclear magnetic resonance are associated with tumor characteristics in breast cancer

 

Univariable

Multivariable

Tumor characteristics

β-coefficient

95 % CI

p-value

β-coefficient

95 % CI

p-value

Progesterone receptor (%)

 Total plasma Apolipoprotein A1, mg/dL

0.41

(0.17, 0.65)

0.001

0.46

(0.22, 0.69)

<0.001

 HDL Cholesterol, mg/dL

0.86

(0.41, 1.31)

<0.001

0.95

(0.51, 1.39)

<0.001

 HDL Free Cholesterol, mg/dL

2.64

(1.03, 4.26)

0.002

2.88

(1.28, 4.48)

0.001

 HDL Phospholipids, mg/dL

0.66

(0.31, 1.01)

<0.001

0.70

(0.36, 1.04)

<0.001

 HDL Apolipoprotein A1, mg/dL

0.50

(0.22, 0.78)

0.001

0.56

(0.29, 0.83)

<0.001

 HDL Apolipoprotein A2, mg/dL

1.16

(0.06, 2.26)

0.040

1.53

(0.48, 2.58)

0.005

 HDL1 Phospholipids, mg/dL

1.02

(0.39, 1.64)

0.002

0.96

(0.35, 1.57)

0.003

 HDL1Cholesterol, mg/dL

1.20

(0.43, 1.97)

0.003

1.15

(0.41, 1.89)

0.003

 HDL1Free Cholesterol, mg/dL

3.36

(0.80, 5.92)

0.011

3.44

(0.95, 5.93)

0.008

 HDL1 Apolipoprotein A1, mg/dL

0.81

(0.29, 1.34)

0.003

0.76

(0.25, 1.27)

0.004

 HDL1 Apolipoprotein A2, mg/dL

6.75

(2.20, 11.3)

0.004

6.39

(2.08, 10.7)

0.004

 HDL2 Phospholipids, mg/dL

2.54

(0.95, 4.13)

0.002

2.30

(0.61, 3.98)

0.008

 HDL2 Cholesterol, mg/dL

3.87

(1.19, 6.54)

0.005

4.42

(1.70, 7.15)

0.002

 HDL2 Free Cholesterol, mg/dL

10.9

(3.48, 18.4)

0.005

11.6

(4.39, 18.9)

0.002

 HDL2 Apolipoprotein A2, mg/dL

6.01

(0.26, 11.8)

0.041

6.74

(1.26, 12.2)

0.017

 HDL2 Apolipoprotein A1, mg/dL

2.15

(0.79, 3.51)

0.003

2.29

(0.95, 3.63)

0.001

 HDL3 Phospholipids, mg/dL

2.53

(0.95, 4.11)

0.002

2.88

(1.32, 4.43)

0.001

 HDL3 Cholesterol, mg/dL

3.75

(1.28, 6.22)

0.004

4.44

(1.94, 6.95)

0.001

 HDL3 Free Cholesterol, mg/dL

11.48

(3.06, 19.9)

0.008

13.5

(5.05, 22.0)

0.002

 HDL3 Apolipoprotein A1, mg/dL

2.04

(0.73, 3.34)

0.003

2.38

(1.09, 3.66)

0.001

 VLDL4 Cholesterol, mg/dL

−3.59

(−6.88,−0.31)

0.033

−3.76

(−7.16,−0.37)

0.031

 VLDL 4 Free Cholesterol, mg/dL

−7.59

(−14.9, −0.27)

0.043

−7.75

(−15.3,−0.20)

0.044

Ki 67, %

 HDL Phospholipids, mg/dL

−0.25

(−0.47, −0.02)

0.033

−0.31

(−0.53,−0.08)

0.008

 HDL1 Cholesterol, mg/dL

−0.48

(−0.96, −0.01)

0.048

−0.54

(−1.00,−0.07)

0.024

 HDL1 Phospholipids, mg/dL

−0.40

(−0.80,−0.01)

0.043

−0.46

(−0.84,−0.08)

0.020

 HDL1 Apolipoprotein A1, mg/dL

−0.31

(−0.64, 0.02)

0.066

−0.35

(−0.67,−0.03)

0.032

 HDL1 Apolipoprotein A2, mg/dL

−3.23

(−6.01,−0.45)

0.024

−3.28

(−5.94,−0.62)

0.017

 HDL2 Phospholipids, mg/dL

−1.08

(−2.06,−0.09)

0.033

−1.30

(−2.28,−0.31)

0.011

Nodal metastasis

 VLDL1 Triglycerides, mg/dL

0.03

(0.00, 0.06)

0.033

0.03

(0.00, 0.07)

0.036

 VLDL1 Free Cholesterol, mg/dL

0.38

(0.01, 0.74)

0.045

0.41

(−0.01, 0.83)

0.057

 LDL2 Free Cholesterol, mg/dL

−0.19

(−0.38,−0.00)

0.049

−0.17

(−0.37, 0.02)

0.084

 LDL3 Free Cholesterol, mg/dL

−0.21

(−0.40,−0.03)

0.026

−0.20

(−0.40,−0.01)

0.049

Estrogen receptor (%)

No significant associations

Grade 1–3

Tumor size, mm

  1. Univariable and multivariable linear regression model. Multivariable model adjusted for age, BMI and menopausal status. 95 % Confidence Interval. Significance level p < 0.05
  2. Abbreviations: HDL high-density lipoprotein, VLDL very-low-density lipoprotein, LDL low-density lipoprotein