Table 2 Association between rs116843064 (E40K) polymorphism, biochemical measurements and clinical features

N

105

12

-

74

28

-

 Age (years)

63,48(61,53–65,44)

67,92(61,97–73,87)

0,22

65,73(63,43–68,03)

67,1(63,24–70,98)

0,5

 Sex (%men)

46,7

66,7

0,78

50

60,7

0,43

 Fasting plasma glucose (mmol/L)

11,56(10,64–12,49)

10,74(7,20–14,28)

0,26

12,52(11,32–13,73)

10,48(8,34–12,61)

0,11

 HbA1c (mmol/L)

10,55(9,76–11,34)

9,85(6,82–12,88)

0,22

11,49(10,42–12,56)

9,57(7,87–11,27)

0,08

BMI (kg/m2)

31,6(28,34–34,87)

29,71(28,93–30,49)

0,05

41,47(31,94–45)

31,16(30,15–32,17)

0,02

Obesity (%)

50

41,9

0,06

75,4

58,1

0,03

Metabolic syndrome (%)

26,7

25

0,12

47,3

67,9

<0,001

 SBP (mm/Hg)

144,63(138,68–150,58)

146,17(119,19–173,14)

0,062

144,44(136,97–151,92)

148,14(140,8–155,48)

0,49

 DBP(mm/Hg)

78,13(74,77–81,49)

76,83(61,87–91,8)

0,08

87,32(82,10–92,55)

87,89(78,99–96,8)

0,84

 Hypertension (%)

51,4

58,3

0,64

71,6

85,7

0,12

 TC (mmol/L)

4,79(4,58–5)

4,87(4,15–5,6)

0,27

4,73(4,44–5,03)

5,18(4,76–5,61)

0,06

TG (mmol/L)

1,72(1,51–1,94)

1,59(1,21–1,97)

0,01

1,9(1,59–2,2)

1,65(1,19–2,32)

<0,001

 HDL-C (mmol/L)

1,32(1,23–1,41)

1,43(1,19–1,67)

0,07

1,21(1,06–1,35)

1,23(1,03–1,44)

0,08

 LDL-C (mmol/L)

3,2(2,97–3,44)

3,36(2,69–4,03)

0,06

4,36(3,99–4,73)

4,34(3,78–5,09)

0,07

 Insulin (%)

41

33,3

0,33

75,7

82,1

0,44