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Table 7 Relation between genotypes K469E polymorphism for ICAM 1 gene and the progress of carotid artery atherosclerosis in patients with T2DM

From: Polymorphism rs5498 of the ICAM-1 gene affects the progression of carotid atherosclerosis in patients with type 2 diabetes mellitus

 

ΔCIMT/year

Δ Plaques segments

Δ Sum of the plaques thickness

 

β

p

β

p

β

p

Hypertension (0 = no; 1 = yes)

1.45

0.35

1.26

0.64

1.46

0.92

Systolic pressure (mmHg)

0.12

0.44

0.08

0.32

0.45

0.48

Serum LDL (mmol/L)

0.32

0.40

0.07

0.69

0.53

0.41

Serum HDL (mmol/L)

−0.04

0.18

−0.51

0.34

−0.39

0.90

Hba1c (%)

0.89

0.70

0.13

0.43

0.68

0.28

KE

1.37

0.49

0.74

0.17

1.14

0.37

EE

3.69

0.03

0.25

0.51

1.31

0.62

  1. All models were adjusted by age, sex, smoking, and treatment with statins
  2. The reference group are homozygotes for allele K