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Table 5 Clinical characteristics of HTG subjects according to presence/absence of rare variants

From: Frequency of rare mutations and common genetic variations in severe hypertriglyceridemia in the general population of Spain

Clinical characteristics Mutation carriers (n = 9) Non-mutation carriers (n = 64) p
Age (years) 59.8 ± 11 55,9 ± 12,2 0.017
Male n, (%) 8 (88.9 %) 50 (78.1 %) 0.058
BMI (kg/m2) 26.3 (24.0–29.4) 28,0 (25.9–29.7) 0.276
APOE genotype (%)    0.336
ε2-ε3 33.3 17.2
ε3-ε3 33.3 62.5
ε3-ε4 33.3 14.1
ε4-ε4 0 1.6
ε4-ε2 0 4.7
Triglycerides, mg/dL 583 (529–1095) 669 (580–848) 0.416
Total cholesterol, mg/dL 281 ± 48.9 262 ± 48.1 0.743
HDL cholesterol, mg/dL 40.4 ± 9.67 40.1 ± 10.6 0.881
Diabetes, % 11.1 26.6 0.314
Hypertension, % 22.2 43.7 0.219
Cardiovascular disease, % 22.2 14 0.522
Familial history (%) 22.2 12.5 0.421
  1. Quantitative variables are expressed as mean ± standard deviation, except for variables without normal distribution (median, interquartile range). The qualitative variables are expressed as %. BMI: body mass index
  2. P value was calculated by Student’s t test, Mann - Whitney U and Chi – square, as appropriate