Frequency of rare mutations and common genetic variations in severe hypertriglyceridemia in the general population of Spain

Table 5 Clinical characteristics of HTG subjects according to presence/absence of rare variants

Clinical characteristics	Mutation carriers (n = 9)	Non-mutation carriers (n = 64)	p
Age (years)	59.8 ± 11	55,9 ± 12,2	0.017
Male n, (%)	8 (88.9 %)	50 (78.1 %)	0.058
BMI (kg/m²)	26.3 (24.0–29.4)	28,0 (25.9–29.7)	0.276
APOE genotype (%)			0.336
ε2-ε3	33.3	17.2
ε3-ε3	33.3	62.5
ε3-ε4	33.3	14.1
ε4-ε4	0	1.6
ε4-ε2	0	4.7
Triglycerides, mg/dL	583 (529–1095)	669 (580–848)	0.416
Total cholesterol, mg/dL	281 ± 48.9	262 ± 48.1	0.743
HDL cholesterol, mg/dL	40.4 ± 9.67	40.1 ± 10.6	0.881
Diabetes, %	11.1	26.6	0.314
Hypertension, %	22.2	43.7	0.219
Cardiovascular disease, %	22.2	14	0.522
Familial history (%)	22.2	12.5	0.421

Quantitative variables are expressed as mean ± standard deviation, except for variables without normal distribution (median, interquartile range). The qualitative variables are expressed as %. BMI: body mass index
P value was calculated by Student’s t test, Mann - Whitney U and Chi – square, as appropriate

ISSN: 1476-511X