Action of nicotinic acid on the reversion of hypoxic-inflammatory link on 3T3-L1 adipocytes

Table 2 Expression of leptin, PAI-1 and adiponectin in 3T3-L1 adipocytes

Relative mRNA expression	Control	NA	H 4 h	H 8 h	H 12 h	DH 4 h	DH 8 h	DH 12 h
Leptin	0.2 ± 0.3	0.4 ± 0.007^a	136.4 ± 17.0^b	320.7 ± 72.3^b	571.7 ± 53.6^b	5.06 ± 3.1^c	26.8 ± 9.4^d	74.7 ± 14.1^e
PAI-1	1.4 ± 0.4	0.04 ± 0.04^a	7.3 ± 2.7^b	16.0 ± 2.7^b	30.6 ± 7.4^b	0.2 ± 0.3^c	0.6 ± 0.4^d	8.0 ± 3.5^e
Adiponectin	255.1 ± 130.7	1195.7 ± 418.7^a	2.9 ± 2.0^b	0.6 ± 0.2^b	0.08 ± 0.02^b	278.7 ± 146.7^c	214.3 ± 62.7^d	22.2 ± 9.8^e

Expression of adipokines in adipocytes: ^aNA versus Control group; ^bH 4 h, H 8 h, H 12 h groups versus Control group; ^cDH 4 h versus H 4 h; ^dDH 8 h versus H 8 h; ^eDH 12 h versus H 12 h, p < 0.05. The statistical significance of the differences between variables studied was determined by analysis of variance (ANOVA) - n=10; NA: Nicotinic acid; H: Hypoxia; DH: Drug + Hypoxia

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