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Table 2 Maternal high fat intake markedly regulated intestinal gene expressions related to immune response, signal transduction, cancer and metabolism

From: Maternal high fat intake affects the development and transcriptional profile of fetal intestine in late gestation using pig model

Gene Symbola

Gene name

Fold changeb

P value

CCR7

chemokine (C-C motif) receptor 7

−2.94

0.023

HSPA1L

heat shock 70 kDa protein 1-like

−2.50

0.016

CD8A

CD8a molecule (CD8A)

−2.44

0.035

CD3E

CD3e molecule, epsilon (CD3-TCR complex) (CD3E)

−2.27

0.033

STK17B

serine/threonine kinase 17b

−2.00

0.026

CD40

CD40 molecule, TNF receptor superfamily member 5

−2.00

0.011

CD2

CD2 molecule

−1.89

0.026

SLA-DQA1

MHC class II histocompatibility antigen SLA-DQA

−1.85

0.002

PSTPIP1

proline-serine-threonine phosphatase interacting protein 1

−1.85

0.007

SLAMF6

SLAM family member 6

−1.82

0.046

TP53INP1

tumor protein p53 inducible nuclear protein 1

−1.82

0.000

FAM78A

family with sequence similarity 78, member A

−1.79

0.015

BCL2A1

BCL2-related protein A1

−1.79

0.023

ARHGAP25

Rho GTPase activating protein 25

−1.75

0.011

CD1.1

CD1 antigen

−1.72

0.007

STAT2

signal transducer and activator of transcription 2

−1.69

0.042

ARHGAP30

Rho GTPase activating protein 30

−1.69

0.036

BCL2A1

BCL2-related protein A1

−1.69

0.040

IL10RB

interleukin 10 receptor, beta

−1.67

0.013

GK

glycerol kinase

−1.64

0.041

LTB

mRNA, clone:MLN010057G03, expressed in mesenteric lymph nodes

−1.64

0.031

LCP1

lymphocyte cytosolic protein 1 (L-plastin)

−1.61

0.014

PGM1

phosphoglucomutase 1

−1.61

0.045

NRROS

negative regulator of reactive oxygen species

−1.59

0.049

CYTH4

cytohesin 4

−1.59

0.039

BMP7

bone morphogenetic protein 7

−1.59

0.024

PIK3R5

phosphoinositide-3-kinase, regulatory subunit 5

−1.56

0.009

RGS14

regulator of G-protein signaling 14

−1.54

0.049

GLRX

glutaredoxin (thioltransferase)

−1.54

0.025

SLA-DRB1

MHC class II histocompatibility antigen SLA-DRB1

−1.52

0.028

LPAR2

lysophosphatidic acid receptor 2

−1.52

0.016

THY1

Thy-1 cell surface antigen

−1.52

0.028

TGFB1

transforming growth factor, beta 1

−1.52

0.022

BAZ1A

bromodomain adjacent to zinc finger domain, 1A

−1.52

0.024

CCDC69

coiled-coil domain containing 69

−1.49

0.048

LRRK2

leucine-rich repeat kinase 2

−1.49

0.022

SLA-1

MHC class I antigen 1

−1.49

0.018

CD74

CD74 molecule, major histocompatibility complex, class II invariant chain

−1.49

0.038

SOD2

superoxide dismutase 2, mitochondrial

1.51

0.004

ILF2

interleukin enhancer binding factor 2

1.51

0.021

CYP39A1

cytochrome P450, family 39, subfamily A, polypeptide 1

1.52

0.043

JPH4

junctophilin 4

1.52

0.026

ATCAY

ataxia, cerebellar, Cayman type

1.53

0.008

MATN2

mRNA, clone:OVR010041A03, expressed in ovary

1.53

0.016

CRMP1

Uncharacterized protein

1.54

0.039

RTDR1

mRNA, clone:UTR010010H08, expressed in uterus.

1.55

0.001

SPARCL1

SPARC-like 1 (hevin)

1.56

0.035

MATN2

mRNA, clone:OVR010041A03, expressed in ovary

1.56

0.019

CCN2

connective tissue growth factor

1.57

0.042

TUSC3

mRNA, clone: HTMT10103A12, expressed in hypothalamus

1.58

0.009

ID4

inhibitor of DNA binding 4, dominant negative helix-loop-helix protein

1.58

0.024

SPARC

secreted protein, acidic, cysteine-rich (osteonectin)

1.60

0.035

MEP1A

meprin A, alpha (PABA peptide hydrolase)

1.63

0.018

ARL10

ADP-ribosylation factor-like 10

1.64

0.036

STMN2

stathmin-like 2

1.64

0.039

ACTA2

actin, alpha 2, smooth muscle, aorta

1.66

0.016

SHISA2

shisa family member 2

1.76

0.029

UCHL1

ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)

1.79

0.014

OCRL

oculocerebrorenal syndrome of Lowe

2.01

0.008

SULT1E1

sulfotransferase family 1E, estrogen-preferring, member 1

2.59

0.013

  1. aGenes were selected from the Kyoto Encyclopedia of Genes and Genomes pathways related to intestinal immune response, signal transduction, cancer and metabolism (http://www.genome.jp/kegg/pathway.html)
  2. bThe fold change was based on the ratio of HF group to CON group, n = 4 subpools/group