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Table 3 Differentially expressed genes in fetal intestine by maternal high fat intake and validated by qPCR

From: Maternal high fat intake affects the development and transcriptional profile of fetal intestine in late gestation using pig model

  

Fold changeb

 

Gene symbola

cDNA Microarray

qPCR

P value

ACTA2

1.66

1.10

0.246

SULT1E1

2.59

1.88

0.002

SOD2

1.51

1.75

0.036

BMP7

−1.59

−1.09

0.722

CD40

−2.00

−1.74

0.116

CD74

−1.49

−1.36

0.029

CD8A

−2.44

−1.85

0.049

GK

−1.64

−1.33

0.041

HSPAIL

−2.50

−1.60

0.027

PIK3R5

−1.56

−1.07

0.644

PSTPIP1

−1.85

−1.48

0.083

SLA-1

−1.49

−1.45

0.097

SLA-DQA1

−1.85

−1.79

0.003

SLA-DRB1

−1.52

−1.33

0.136

STAT2

−1.69

−1.18

0.125

TGF-β

−1.52

−1.19

0.296

THY1

−1.52

−1.29

0.118

  1. aGenes were selected on the basis of their crucial role on regulating intestinal immune response (i.e.SLA-DRB1,SLA-DQA,HSPA1L,CD74,CD40), colorectal cancer (i.e.TGF-β,PIK3R5), signal transduction (i.e. PSTPIP1,BMP7,STAT2) and metabolism (i.e.GK, SULT1E1). These genes by DNA microarray were all significantly regulated (P < 0.05, at least 1.5 fold change)
  2. bThe fold change was based on the ratio of HF group to CON group, n = 4 subpools/group