Table 4 The markedly modified signal pathways in fetal intestine of gilts fed HF diet

Allograft rejection

6

34

17.65 %

0.000

Antigen processing and presentation

8

64

12.50 %

0.000

Autoimmune thyroid disease

6

45

13.33 %

0.000

Cell adhesion molecules

8

71

11.27 %

0.000

Cytokine-cytokine receptor interaction

10

142

7.04 %

0.000

Hematopoietic cell lineage

7

63

11.11 %

0.000

Intestinal immune network for IgA production

7

48

14.58 %

0.000

Leishmania infection

8

63

12.70 %

0.000

Viral myocarditis

9

46

19.57 %

0.000

Graft-versus-host disease

6

57

10.53 %

1E-04

Neuroactive ligand-receptor interaction

10

174

5.75 %

1E-04

Type I diabetes mellitus

5

40

12.50 %

2E-04

Asthma

5

50

10.00 %

5E-04

Jak-STAT signaling pathway

6

82

7.32 %

6E-04

Primary immunodeficiency

4

37

10.81 %

0.0013

Pathways in cancer

7

140

5.00 %

0.0017

Hypertrophic cardiomyopathy

4

43

9.30 %

0.0022

Systemic lupus erythematosus

5

86

5.81 %

0.0043

Adipocytokine signaling pathway

4

55

7.27 %

0.005

Chemokine signaling pathway

5

90

5.56 %

0.0052

Colorectal cancer

3

31

9.68 %

0.0072

Fc gamma R-mediated phagocytosis

3

32

9.38 %

0.0078

T cell receptor signaling pathway

4

63

6.35 %

0.0078

Leukocyte transendothelial migration

4

71

5.63 %

0.0115

Acute myeloid leukemia

3

39

7.69 %

0.0129

Dilated cardiomyopathy

3

40

7.50 %

0.0137

Glycerolipid metabolism

3

41

7.32 %

0.0146

Arrhythmogenic right ventricular cardiomyopathy

3

47

6.38 %

0.0205

Nitrogen metabolism

2

19

10.53 %

0.0246

TGF-beta signaling pathway

3

55

5.45 %

0.0302

Endometrial cancer

2

22

9.09 %

0.0316

Aldosterone-regulated sodium reabsorption

2

24

8.33 %

0.0366

Type II diabetes mellitus

2

24

8.33 %

0.0366