APOE SNP | MM | Mm | mm | β (95 % CI) | P valuea | MM | Mm + mm | β (95 % CI) | P valuea |
---|---|---|---|---|---|---|---|---|---|
rs429358 | TT (n = 480) | CT (n = 96) | CC (n = 8) |  |  | TT (n = 480) | CT + CC (n = 104) |  |  |
T-cholesterol (mg/dL) | 197.1 ± 35.9 | 204.2 ± 40.1 | 210.9 ± 28.2 | 6.67 (−0.13–13.46) | 0.054 | 197.1 ± 35.9 | 204.7 ± 39.3 | 7.03 (−0.56–14.63) | 0.069 |
LDL-C (mg/dL) | 114.5 ± 32.4 | 121.0 ± 35.7 | 132.1 ± 23.0 | 7.02 (0.90–13.14) | 0.025 | 114.5 ± 32.4 | 121.8 ± 34.9 | 7.06 (0.22–13.91) | 0.043 |
HDL-C (mg/dL) | 55.8 ± 14.7 | 52.3 ± 12.1 | 51.3 ± 13.3 | −0.29 (−0.038 to −0.001) | 0.040 | 55.8 ± 14.7 | 52.2 ± 12.1 | −0.02 (−0.04–0.001) | 0.063 |
Triglyceride (mg/dL) | 138.3 ± 119.9 | 165.1 ± 122.7 | 138.0 ± 68.5 | 0.047 (0.004–0.09) | 0.034 | 138.3 ± 119.9 | 163.0 ± 119.4 | 0.055 (0.006–0.103) | 0.027 |
CRP (mg/L) | 1.12 ± 1.40 | 0.79 ± 1.19 | 1.96 ± 1.99 | −0.12 (−0.21 to −0.04) | 0.005 | 1.12 ± 1.40 | 0.88 ± 1.29 | −0.17 (−0.27 to −0.08) | 3.8 x 10−4 |
rs7412 | CC (n = 496) | CT (n = 84) | TT (n = 5) |  |  | CC (n = 496) | CT + TT (n = 89) |  |  |
T-cholesterol (mg/dL) | 201.0 ± 35.5 | 184.3 ± 37.9 | 169.8 ± 65.8 | −15.77 (−23.13 to −8.40) | 3.01 x 10−5 | 201.0 ± 35.5 | 183.5 ± 39.5 | −17.08 (−25.08–9.08) | 3.2 x 10−5 |
LDL-C (mg/dL) | 118.9 ± 32.1 | 100.2 ± 31.8 | 65.0 ± 21.4 | −19.82 (−26.36 to −13.28) | 4.55 x 10−9 | 118.9 ± 32.1 | 98.3 ± 32.3 | −20.36 (−27.49–13.24) | 3.1 x 10−8 |
HDL-C (mg/dL) | 54.7 ± 14.2 | 57.8 ± 15.3 | 50.4 ± 8.5 | 0.01 (−0.007–0.34) | 0.188 | 54.7 ± 14.2 | 57.4 ± 15.0 | 0.02 (−0.005–0.04) | 0.129 |
Triglyceride (mg/dL) | 143.6 ± 121.1 | 133.2 ± 108.9 | 217.8 ± 176.1 | 0.001 (−0.046–0.049) | 0.957 | 143.6 ± 121.1 | 137.9 ± 113.9 | −0.009 (−0.06–0.04) | 0.730 |
CRP (mg/L) | 1.08 ± 1.33 | 1.10 ± 1.67 | 0.75 ± 0.68 | −0.12 (−0.11–0.08) | 0.709 | 1.08 ± 1.33 | 1.08 ± 1.63 | −0.01 (−0.11–0.09) | 0.795 |