Characteristic | Insulin sensitivity | Insulin resistance | P-value |
---|---|---|---|
HOMA-IR ≤ 2.69 | HOMA-IR > 2.69 | ||
N = 241 | N = 238 | ||
Diabetes (%) | 29 (12.03) | 72 (30.25) | 0.000* |
Pre-diabetes (%) | 87 (36.10) | 99 (41.60) | 0.217 |
NGT (%) | 125 (51.87) | 67 (28.15) | 0.000 |
Female (%) | 153 (63.49) | 158 (66.39) | 0.468 |
Age, years | 53.06 ± 10.99 | 51.92 ± 11.25 | 0.267 |
BMI, kg/m2 | 24.39 ± 3.13 | 27.76 ± 3.68 | 0.000* |
Overweight/obesity (%) | 124 (51.45) | 206 (86.55) | 0.000* |
Waist circumference, cm | 83.96 ± 9.38 | 89.88 ± 8.97 | 0.000* |
Hip circumference, cm | 89.30 ± 9.38 | 89.88 ± 8.97 | 0.000* |
Systolic BP, mm Hg | 127.22 ± 19.17 | 127.65 ± 18.03 | 0.804 |
Diastolic BP, mm Hg | 75.83 ± 10.19 | 76.83 ± 10.11 | 0.391 |
HbA1c% | 5.58 ± 0.76 | 5.97 ± 1.04 | 0.000* |
Fasting plasma glucose, mmol/L | 5.90 ± 1.40 | 6.78 ± 1.95 | 0.000* |
Postprandial glucose (PG 30’), mmol/L | 10.06 ± 2.97 | 11.67 ± 3.47 | 0.000* |
PG 60’, mmol/L | 9.42 ± 3.97 | 11.54 ± 4.99 | 0.000* |
PG 120’, mmol/L | 7.44 ± 3.56 | 9.44 ± 5.15 | 0.000* |
Ln (Ins 0’, mU/L) | 1.88 ± 0.33 | 2.69 ± 0.36 | 0.000* |
Ln (Ins 30’, mU/L) | 3.83 ± 0.67 | 4.41 ± 0.69 | 0.000* |
Ln (Ins 60’, mU/L) | 3.84 ± 0.62 | 4.48 ± 0.46 | 0.000* |
Ln (Ins 120’, mU/L) | 3.37 ± 0.73 | 4.07 ± 0.70 | 0.000* |
Ln (C peptide 0’, ng/mL) | 0.02 ± 0.28 | 0.58 ± 0.31 | 0.000* |
Ln (C peptide 30’, ng/mL) | 1.35 ± 0.44 | 1.67 ± 0.49 | 0.000* |
Ln (C peptide 60’, ng/mL) | 1.58 ± 0.42 | 1.91 ± 0.46 | 0.000* |
Ln (C peptide 120’, ng/mL) | 1.46 ± 0.46 | 1.82 ± 0.46 | 0.000* |
InsAUC30/GluAUC30 (mU/mmol) | 4.18 ± 2.80 | 7.08 ± 5.02 | 0.000* |
InsAUC120/GluAUC120 (mU/mmol) | 5.60 ± 3.09 | 10.44 ± 4.97 | 0.000* |
Sqrt HOMA-β | 7.94 ± 1.88 | 10.45 ± 2.83 | 0.000* |
Sqrt DI30 | 21.79 ± 6.27 | 18.47 ± 6.75 | 0.000* |
Sqrt DI120 | 25.33 ± 5.97 | 21.59 ± 8.13 | 0.000* |
Ln [(ΔIns30/ΔGlu30)/HOMA-IR] | 2.01 ± 0.91 | 1.58 ± 0.84 | 0.000* |
Total cholesterol (TC), mmol/L | 5.41 ± 0.95 | 5.56 ± 1.09 | 0.113 |
Log (triglyceride [TG]) mmol/L) | 0.08 ± 0.22 | 0.26 ± 0.27 | 0.000* |
Log (HDL-C, mmol/L) | 0.12 ± 0.10 | 0.08 ± 0.08 | 0.000* |
LDL-C, mmol/L | 2.73 ± 0.68 | 2.94 ± 0.73 | 0.001* |
Log (TG/HDL-C) | −0.04 ± 0.28 | 0.18 ± 0.30 | 0.000* |
TC/HDL-C | 4.12 ± 0.94 | 4.62 ± 0.94 | 0.000* |
LDL-C/HDL-C | 2.10 ± 0.67 | 2.45 ± 0.64 | 0.000* |