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Table 3 Degree of concordance among apoB, LDL-C, and non-HDL-C levels at baseline and study endpoint in the pooled treatment groups for the overall population and treatment subgroups defined by baseline TG < and ≥2.26 mmol/L

From: Effects of extended-release niacin/laropiprant on correlations between apolipoprotein B, LDL-cholesterol and non-HDL-cholesterol in patients with type 2 diabetes

  N Concordance between apoB and LDL-C N Concordance between apoB and Non-HDL-C
Weighted kappaa (95 % CI)   Weighted kappaa (95 % CI)
Baseline (i.e., drug-naïve patients)
Overall Population
All Treatments 716 0.49 (0.44, 0.53) 716 0.66 (0.62, 0.69)
 TG <2.26 mmol/L 599 0.52 (0.47, 0.56) 599 0.63 (0.60, 0.67)
 TG ≥2.26 mmol/L 117 0.56 (0.46, 0.65) 117 0.64 (0.56, 0.72)
ERN/LRPT 393 0.50 (0.45, 0.56) 393 0.67 (0.63, 0.72)
 TG <2.26 mmol/L 320 0.54 (0.49, 0.60) 320 0.65 (0.60, 0.70)
 TG ≥2.26 mmol/L 73 0.56 (0.44, 0.68) 73 0.65 (0.56, 0.75)
Placebo 323 0.46 (0.40, 0.53) 323 0.65 (0.60, 0.70)
 TG <2.26 mmol/L 279 0.50 (0.43, 0.57) 279 0.64 (0.58, 0.69)
 TG ≥2.26 mmol/L 44 0.55 (0.39, 0.71) 44 0.71 (0.56, 0.85)
Endpoint (i.e., following randomized treatment)
Overall Population
All Treatments 716 0.61 (0.57, 0.64) 716 0.73 (0.70, 0.76)
 TG <2.26 mmol/L 599 0.64 (0.60, 0.68) 599 0.73 (0.70, 0.76)
 TG ≥2.26 mmol/L 117 0.57 (0.47, 0.67) 117 0.70 (0.63, 0.78)
ERN/LRPT 393 0.64 (0.60, 0.69) 393 0.73 (0.69, 0.77)
 TG <2.26 mmol/L 320 0.66 (0.61, 0.71) 320 0.72 (0.67, 0.76)
 TG ≥2.26 mmol/L 73 0.64 (0.54, 0.75) 73 0.71 (0.60, 0.82)
Placebo 323 0.53 (0.46, 0.59) 323 0.65 (0.60, 0.71)
 TG <2.26 mmol/L 279 0.55 (0.49, 0.62) 279 0.66 (0.61, 0.72)
 TG ≥2.26 mmol/L 44 0.53 (0.38, 0.69) 44 0.68 (0.56, 0.81)
  1. ERN/LRPT niacin/laropiprant; apoB apolipoprotein B DL-C low-density lipoprotein cholesterol; HDL-C high-density lipoprotein cholesterol; TG triglyceride
  2. aThe k statistic, on a scale from 0 to 1, reflects the degree of agreement between two variables. The levels of agreement range from slight (0–0.20), fair (0.21–0.40), moderate (0.41–0.60), substantial (0.61–0.80), and almost perfect (0.81–1.00)