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Table 2 Significantly upregulated proteins in LPON treated cells

From: Proteomic profiling of cellular steatosis with concomitant oxidative stress in vitro

Accession

Description

HGNC symbol

Peptide count

Confidence score

P-value

Fold change from control

NP_000468.1

serum albumin preproprotein

ALB

4

173.4

0.00

11.33

NP_001113.2

perilipin-2

PLIN2

6

387.7

0.02

10.42

NP_000030.1

apolipoprotein A-I preproprotein

APOA1

2

107.5

0.02

4.08

NP_004453.3

squalene synthase

FDFT1

3

159.4

0.02

3.22

NP_005327.1

vigilin

HDLBP

3

137.1

0.00

2.72

NP_005902.1

S-adenosylmethionine synthase isoform type-2

MAT2A

3

195.1

0.00

2.50

NP_001344.2

aldo-keto reductase family 1 member C1

AKR1C1

4

226.8

0.00

2.41

NP_006627.2

bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial precursor

MTHFD2

2

59.6

0.02

2.39

NP_009224.2

complement C4-A preproprotein

C4A

3

119.5

0.01

2.36

NP_006382.1

importin-7

IPO7

2

55.6

0.01

2.35

NP_036205.1

T-complex protein 1 subunit epsilon

CCT5

4

255.7

0.00

2.30

NP_001407.1

eukaryotic initiation factor 4A-I

EIF4A1

7

314.6

0.00

2.28

NP_000032.1

apolipoprotein E precursor

APOE

3

152.7

0.00

2.21

NP_001054.1

serotransferrin precursor

TF

6

369.9

0.02

2.18

NP_001165908.1

retrotransposon-derived protein PEG10 isoform 3

PEG10

2

185.2

0.01

2.13

NP_149351.1

surfeit locus protein 4

SURF4

2

251.8

0.01

2.13

NP_002769.1

proactivator polypeptide isoform a preproprotein

PSAP

4

243.4

0.00

2.09

NP_001952.1

elongation factor 2

EEF2

13

713.0

0.00

2.07

NP_055121.1

hypothetical protein LOC51493

RTCB

2

88.1

0.01

2.05

NP_001434.1

fatty acid-binding protein, liver

FABP1

4

329.0

0.02

2.01

NP_110379.2

T-complex protein 1 subunit alpha isoform a

TCP1

6

392.6

0.01

2.01

NP_056348.2

bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing)

TKFC

3

169.5

0.03

2.00

NP_000508.1

hemoglobin subunit alpha

HBA2

2

80.4

0.01

1.99

NP_001159757.1

T-complex protein 1 subunit eta isoform d

CCT7

2

194.3

0.01

1.93

NP_000448.3

hepatocyte nuclear factor 4-alpha isoform b

HNF4A

2

109.1

0.00

1.92

NP_001753.1

T-complex protein 1 subunit zeta isoform a

CCT6A

5

408.0

0.01

1.92

NP_001650.1

ADP-ribosylation factor 3

ARF3

3

268.5

0.00

1.90

NP_006364.2

synaptic vesicle membrane protein VAT-1 homolog

VAT1

3

174.1

0.01

1.89

NP_006262.1

protein S100-A1

S100A1

2

215.4

0.02

1.88

NP_000867.2

cation-independent mannose-6-phosphate receptor precursor

IGF2R

3

103.2

0.02

1.88

NP_000383.1

canalicular multispecific organic anion transporter 1

ABCC2

2

104.3

0.05

1.86

NP_001596.2

alanyl-tRNA synthetase, cytoplasmic

AARS

3

150.6

0.02

1.81

NP_002286.2

40S ribosomal protein SA

RPSA

3

194.7

0.00

1.80

NP_001171669.1

src substrate cortactin isoform c

CTTN

2

62.4

0.01

1.80

NP_005882.2

acetyl-CoA acetyltransferase, cytosolic

ACAT2

3

159.6

0.02

1.79

NP_001016.1

40S ribosomal protein S23

RPS23

2

63.0

0.00

1.76

NP_056174.2

zinc transporter ZIP14 isoform b

SLC39A14

3

178.6

0.02

1.76

NP_003730.4

aldo-keto reductase family 1 member C3

AKR1C3

3

257.7

0.02

1.73

NP_005971.1

protein S100-P

S100P

3

164.9

0.02

1.72

NP_002622.2

6-phosphogluconate dehydrogenase, decarboxylating

PGD

5

502.0

0.02

1.70

NP_005821.2

28S ribosomal protein S31, mitochondrial precursor

MRPS31

2

78.2

0.00

1.68

NP_001012.1

40S ribosomal protein S17

RPS17

5

349.2

0.01

1.68

NP_006422.1

T-complex protein 1 subunit beta isoform 1

CCT2

5

481.5

0.03

1.68

NP_001018146.1

NME1-NME2 protein

NME1

2

105.5

0.00

1.67

NP_004035.2

bifunctional purine biosynthesis protein PURH

ATIC

5

247.7

0.00

1.67

NP_038203.2

isoleucyl-tRNA synthetase, cytoplasmic

IARS

2

95.1

0.02

1.65

NP_000775.1

sterol 26-hydroxylase, mitochondrial precursor

CYP27A1

2

130.2

0.03

1.64

NP_006545.1

metaxin-2

MTX2

2

127.2

0.00

1.64

NP_002203.1

eukaryotic translation initiation factor 6 isoform a

EIF6

3

267.9

0.00

1.64

NP_006089.1

guanine nucleotide-binding protein subunit beta-2-like 1

GNB2L1

5

233.4

0.00

1.64

NP_001961.1

eukaryotic translation initiation factor 5A-1 isoform B

EIF5A

4

164.5

0.04

1.64

NP_631961.1

TATA-binding protein-associated factor 2 N isoform 1

TAF15

2

126.7

0.00

1.63

NP_001002.1

40S ribosomal protein S7

RPS7

3

178.1

0.00

1.62

NP_004387.1

probable ATP-dependent RNA helicase DDX5

DDX5

3

145.9

0.02

1.61

NP_036555.1

60S ribosomal protein L13a

RPL13A

2

72.2

0.00

1.61

NP_000996.2

40S ribosomal protein S3

RPS3

6

264.7

0.01

1.60

NP_006752.1

14-3-3 protein epsilon

YWHAE

3

221.6

0.00

1.60

NP_055205.2

staphylococcal nuclease domain-containing protein 1

SND1

12

567.8

0.00

1.58

NP_001000.2

40S ribosomal protein S5

RPS5

3

266.6

0.01

1.57

NP_005557.1

L-lactate dehydrogenase A chain isoform 1

LDHA

6

527.9

0.01

1.57

NP_005337.2

heat shock 70 kDa protein 1A/1B

HSPA1B

8

517.1

0.01

1.57

NP_061819.2

sialic acid synthase

NANS

3

152.4

0.01

1.56

NP_001419.1

alpha-enolase

ENO1

14

1032.9

0.02

1.56

NP_733779.1

S-phase kinase-associated protein 1 isoform b

SKP1

3

123.7

0.01

1.55

NP_002385.3

4 F2 cell-surface antigen heavy chain isoform c

SLC3A2

11

680.1

0.03

1.53

NP_001279.2

chloride intracellular channel protein 1

CLIC1

4

251.6

0.00

1.53

NP_000792.1

peptidyl-prolyl cis-trans isomerase FKBP1A isoform a

FKBP1A

2

126.4

0.01

1.52

NP_001393.1

elongation factor 1-alpha 1

EEF1A1

16

996.3

0.00

1.52

NP_003893.2

far upstream element-binding protein 1

FUBP1

2

165.0

0.00

1.52

NP_006392.1

acidic leucine-rich nuclear phosphoprotein 32 family member B

ANP32B

2

149.5

0.02

1.50

  1. Of the 104 proteins that met the criteria for Category 1, 70 were significantly upregulated with LPON
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Lipids in Health and Disease

ISSN: 1476-511X