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Table 2 Postoperative plasma lipid and lipoprotein levels in consecutive 5-year periods in statin-treated patients undergone CABG

From: Prompt impact of first prospective statin mega-trials on postoperative lipid management of CABG patients: a 20-year follow-up in a single hospital

5-year period

1990–1994

1995–1999

2000–2004

2005–2009

Overall p a

DSDI

0.07 ± 0.23

0.46 ± 0.53

1.25 ± 1.19

2.52 ± 1.52

<0.0001

T-C (mmol/l)

5.70 ± 1.27

4.86 ± 1.00

4.20 ± 0.91

3.76 ± 0.82

<0.0001

LDL-C (mmol/l)b

3.70 ± 1.09

2.94 ± 0.85

2.35 ± 0.72

2.07 ± 0.64

<0.0001

HDL-C (mmol/l)

1.02 ± 0.29

1.12 ± 0.33

1.24 ± 0.32

1.22 ± 0.34

<0.0001

T-G (mmol/l)

2.20 ± 1.22

1.79 ± 0.96

1.56 ± 0.81

1.40 ± 0.65

<0.0001

Extended Friedewald approach (eFW)c

VLDL-TG (mmol/l)

1.36 ± 0.85

1.12 ± 0.79

0.95 ± 0.6

0.85 ± 0.

<0.0001

IDL-C (mmol/l)

0.38 ± 0.14

0.28 ± 0.11

0.23 ± 0.11

0.23 ± 0.16

<0.0001

LDL-C (mmol/l)

3.55 ± 0.78

3.01 ± 0.71

2.49 ± 0.63

2.21 ± 0.51

<0.0001

HDL-2-C (mmol/l)

0.57 ± 0.23

0.67 ± 0.27

0.76 ± 0.27

0.77 ± 0.28

<0.0001

HDL-3-C (mmol/l)

0.46 ± 0.07

0.47 ± 0.07

0.48 ± 0.07

0.48 ± 0.07

0.0121

ApoA1 (g/l)

1.38 ± 0.22

1.38 ± 0.24

1.42 ± 0.24

1.37 ± 0.26

0.1864

ApoB (g/l)

1.30 ± 0.26

1.09 ± 0.26

0.90 ± 0.23

0.81 ± 0.18

<0.0001

  1. Mean ± standard deviation are presented
  2. Abbreviations: DSDI daily statin dose index, where the 1.0 corresponds the dose of simvastatin 20 mg per day (see Methods). In the intention to threat analysis all patients are included
  3. aANOVA was used for overall analysis
  4. bLDL-C is determined using Friedewald calculation
  5. cThe eFW is based on artificial neural network regression algorithms which utilize data on classical FW inputs (see Methods)