Skip to main content

Table 3 Biomarkers for lipid metabolism, oxidation and inflammation; blood counts and biochemistry per group at start (baseline) and end (16 weeks) of fish oil or corn oil trial

From: Evaluating oxidative stress, serological- and haematological status of dogs suffering from osteoarthritis, after supplementing their diet with fish or corn oil

Variable

Fish oil

Corn oil

Between Groups

Baseline

End of trial

P-value/direction

Baseline

End of trial

P-value/direction

Baseline P-value

End P-value

Oxidation marker

 MDA (μmol/l)

3.41 ± 1.34

2.43 ± 0.92

<0.001 ↓

3.41 ± 1.34

2.41 ± 1.01

0.001 ↓

0.957

0.926

 GSH (mmol/l)

1.97 ± 0.22

2.02 ± 0.17

0.200

2.01 ± 0.21

2.07 ± 0.22

0.184

0.645

0.296

 8-OH-dG (pg/ml)

1.54 ± 0.60

1.64 ± 0.74

0.315

1.68 ± 0.60

1.75 ± 0.79

0.410

0.340

0.545

 NTBI (μmol/l)

−1.36 ± 4.11

−1.92 ± 2.58

0.248

−1.25 ± 2.17

−2.31 ± 1.64

0.002↓

0.950

0.445

 FCar (μmol/l)

18.18 ± 9.78

21.19 ± 9.58

0.004 ↑

20.53 ± 9.78

22.23 ± 10.12

0.121

0.222

0.657

Haemograms (Unit) RV = Reference value

 Haematocrit % RV = 38–57

50.15 ± 4.24

47.55 ± 8.95

0.096

49.22 ± 5.15

48.38 ± 5.88

0.237

0.729

0.881

 Haemoglobin (g/l) RV = 140–203

164.23 ± 14.00

162.57 ± 15.19

0.453

160.41 ± 16.71

160.94 ± 19.23

0.816

0.616

0.409

 MCV (fl) RV = 67–80

69.17 ± 2.15

68.73 ± 2.23

0.010 ↓

69.90 ± 3.11

69.76 ± 2.54

0.636

0.339

0.180

 MCH (pg) RV = 24–29

22.64 ± 0.77

22.88 ± 0.87

0.003 ↑

22.76 ± 0.95

23.20 ± 0.97

<0.001 ↑

0.572

0.494

 MCHC (g/l) RV = 345–367

327.33 ± 3.96

332.80 ± 5.93

<0.001 ↑

325.81 ± 6.18

332.56 ± 6.79

<0.001 ↑

0.379

0.364

 Platelet (n × 109/l) RV = 102–395

304.76 ± 88.37

309.83 ± 98.56

0.692

316.13 ± 93.83

288.41 ± 101.68

0.029 ↓

0.991

0.513

 RBC (n × 1012/l) RV = 5.3–8.0

7.25 ± 0.61

7.11 ± 0.74

0.198

7.04 ± .76

6.94 ± 0.84

0.319

0.474

0.291

 WBC (n × 109/l) RV = 5.4–17.4

8.37 ± 2.27

8.20 ± 2.36

0.564

8.45 ± 3.22

8.51 ± 3.31

0.913

0.712

0.975

 Neutrophil % RV = 40–80

68.97 ± 10.52

66.46 ± 14.40

0.350

69.89 ± 11.30

70.56 ± 8.44

0.644

0.971

0.195

 Lymphocyte % RV = 10–36

18.10 ± 8.61

19.68 ± 7.74

0.109

16.11 ± 7.20

16.82 ± 5.88

0.482

0.504

0.166

 Monocyte % RV = 0–13

3.84 ± 2.50

1.77 ± 1.92

<0.001 ↓

4.11 ± 3.02

3.06 ± 2.70

0.050 ↓

0.340

0.030 a

 Eosinophil % RV = 2–10

7.59 ± 3.53

9.01 ± 4.79

0.069

8.54 ± 5.33

8.42 ± 6.00

0.927

0.605

0.551

 Basophil % RV = 0–1

1.47 ± 1.22

0.62 ± 0.62

0.001

1.33 ± 1.08

1.13 ± 0.96

0.396

0.882

0.012 a

Blood biochemistry

 Urea (mmol/l) RV = 2.4–8.8

5.23 ± 1.61

5.48 ± 1.31

0.308

5.12 ± 1.37

5.25 ± 1.80

0.695

0.430

0.536

 Creatinine (μmol/l) RV = 57–116

86.85 ± 9.36

90.65 ± 11.73

0.008 ↑

88.62 ± 13.34

93.51 ± 14.85

0.001 ↑

0.372

0.311

 ALP (U/l) RV = 33–215

127.83 ± 143.75

146.85 ± 170.32

0.052

147.32 ± 107.88

153.70 ± 116.36

0.283

0.598

0.843

 ALT (U/l) RV = 18–77

52.35 ± 24.24

77.22 ± 136.25

0.279

58.60 ± 26.96

58.12 ± 28.77

0.888

0.452

0.414

 Albumin (g/l) RV = 30–41

33.68 ± 2.02

33.77 ± 2.57

0.790

32.80 ± 2.39

33.24 ± 2.51

0.160

0.129

0.385

 Total protein (g/l) RV = 58–77

63.53 ± 4.07

64.42 ± 4.34

0.158

63.97 ± 3.18

64.50 ± 3.59

0.469

0.990

0.932

 Glucose (mmol/l) RV = 4.0–6.4

5.22 ± 0.38

5.34 ± 0.43

0.171

5.18 ± 0.37

5.32 ± 0.47

0.041 ↑

0.645

0.854

 Cholesterol (mmol/l) RV = 3.7–9.8

6.51 ± 1.90

6.94 ± 2.40

0.109

7.13 ± 1.62

7.73 ± 2.03

0.011 ↑

0.463

0.135

 Triglycerides (mmol/l) RV = 0.5–1.1

0.79 ± 0.37

0.71 ± 0.46

0.406

0.80 ± 0.31

0.81 ± 0.36

0.854

0.299

0.335

  1. MCV Mean Corpuscular Volume, MCH Mean Corpuscular Haemoglobin, MCHC Mean Corpuscular Haemoglobin Concentration, RDW Red Cell Distribution Width, RBC Red Blood Cell Count, WBC White Blood Cell Count, ALP Alkaline Phosphatase, ALT Alanine Aminotransferase. P-values for changes within and between groups; significant (P < 0.05) values bolded. aLower counts in the Fish oil group; bHigher values in the Corn oil group. RV Reference value. ↑ Value increased significantly; ↓ Value decreased significantly