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Table 3 Biomarkers for lipid metabolism, oxidation and inflammation; blood counts and biochemistry per group at start (baseline) and end (16 weeks) of fish oil or corn oil trial

From: Evaluating oxidative stress, serological- and haematological status of dogs suffering from osteoarthritis, after supplementing their diet with fish or corn oil

Variable Fish oil Corn oil Between Groups
Baseline End of trial P-value/direction Baseline End of trial P-value/direction Baseline P-value End P-value
Oxidation marker
 MDA (μmol/l) 3.41 ± 1.34 2.43 ± 0.92 <0.001 ↓ 3.41 ± 1.34 2.41 ± 1.01 0.001 ↓ 0.957 0.926
 GSH (mmol/l) 1.97 ± 0.22 2.02 ± 0.17 0.200 2.01 ± 0.21 2.07 ± 0.22 0.184 0.645 0.296
 8-OH-dG (pg/ml) 1.54 ± 0.60 1.64 ± 0.74 0.315 1.68 ± 0.60 1.75 ± 0.79 0.410 0.340 0.545
 NTBI (μmol/l) −1.36 ± 4.11 −1.92 ± 2.58 0.248 −1.25 ± 2.17 −2.31 ± 1.64 0.002↓ 0.950 0.445
 FCar (μmol/l) 18.18 ± 9.78 21.19 ± 9.58 0.004 20.53 ± 9.78 22.23 ± 10.12 0.121 0.222 0.657
Haemograms (Unit) RV = Reference value
 Haematocrit % RV = 38–57 50.15 ± 4.24 47.55 ± 8.95 0.096 49.22 ± 5.15 48.38 ± 5.88 0.237 0.729 0.881
 Haemoglobin (g/l) RV = 140–203 164.23 ± 14.00 162.57 ± 15.19 0.453 160.41 ± 16.71 160.94 ± 19.23 0.816 0.616 0.409
 MCV (fl) RV = 67–80 69.17 ± 2.15 68.73 ± 2.23 0.010 ↓ 69.90 ± 3.11 69.76 ± 2.54 0.636 0.339 0.180
 MCH (pg) RV = 24–29 22.64 ± 0.77 22.88 ± 0.87 0.003 22.76 ± 0.95 23.20 ± 0.97 <0.001 0.572 0.494
 MCHC (g/l) RV = 345–367 327.33 ± 3.96 332.80 ± 5.93 <0.001 325.81 ± 6.18 332.56 ± 6.79 <0.001 0.379 0.364
 Platelet (n × 109/l) RV = 102–395 304.76 ± 88.37 309.83 ± 98.56 0.692 316.13 ± 93.83 288.41 ± 101.68 0.029 ↓ 0.991 0.513
 RBC (n × 1012/l) RV = 5.3–8.0 7.25 ± 0.61 7.11 ± 0.74 0.198 7.04 ± .76 6.94 ± 0.84 0.319 0.474 0.291
 WBC (n × 109/l) RV = 5.4–17.4 8.37 ± 2.27 8.20 ± 2.36 0.564 8.45 ± 3.22 8.51 ± 3.31 0.913 0.712 0.975
 Neutrophil % RV = 40–80 68.97 ± 10.52 66.46 ± 14.40 0.350 69.89 ± 11.30 70.56 ± 8.44 0.644 0.971 0.195
 Lymphocyte % RV = 10–36 18.10 ± 8.61 19.68 ± 7.74 0.109 16.11 ± 7.20 16.82 ± 5.88 0.482 0.504 0.166
 Monocyte % RV = 0–13 3.84 ± 2.50 1.77 ± 1.92 <0.001 ↓ 4.11 ± 3.02 3.06 ± 2.70 0.050 ↓ 0.340 0.030 a
 Eosinophil % RV = 2–10 7.59 ± 3.53 9.01 ± 4.79 0.069 8.54 ± 5.33 8.42 ± 6.00 0.927 0.605 0.551
 Basophil % RV = 0–1 1.47 ± 1.22 0.62 ± 0.62 0.001 1.33 ± 1.08 1.13 ± 0.96 0.396 0.882 0.012 a
Blood biochemistry
 Urea (mmol/l) RV = 2.4–8.8 5.23 ± 1.61 5.48 ± 1.31 0.308 5.12 ± 1.37 5.25 ± 1.80 0.695 0.430 0.536
 Creatinine (μmol/l) RV = 57–116 86.85 ± 9.36 90.65 ± 11.73 0.008 88.62 ± 13.34 93.51 ± 14.85 0.001 0.372 0.311
 ALP (U/l) RV = 33–215 127.83 ± 143.75 146.85 ± 170.32 0.052 147.32 ± 107.88 153.70 ± 116.36 0.283 0.598 0.843
 ALT (U/l) RV = 18–77 52.35 ± 24.24 77.22 ± 136.25 0.279 58.60 ± 26.96 58.12 ± 28.77 0.888 0.452 0.414
 Albumin (g/l) RV = 30–41 33.68 ± 2.02 33.77 ± 2.57 0.790 32.80 ± 2.39 33.24 ± 2.51 0.160 0.129 0.385
 Total protein (g/l) RV = 58–77 63.53 ± 4.07 64.42 ± 4.34 0.158 63.97 ± 3.18 64.50 ± 3.59 0.469 0.990 0.932
 Glucose (mmol/l) RV = 4.0–6.4 5.22 ± 0.38 5.34 ± 0.43 0.171 5.18 ± 0.37 5.32 ± 0.47 0.041 0.645 0.854
 Cholesterol (mmol/l) RV = 3.7–9.8 6.51 ± 1.90 6.94 ± 2.40 0.109 7.13 ± 1.62 7.73 ± 2.03 0.011 0.463 0.135
 Triglycerides (mmol/l) RV = 0.5–1.1 0.79 ± 0.37 0.71 ± 0.46 0.406 0.80 ± 0.31 0.81 ± 0.36 0.854 0.299 0.335
  1. MCV Mean Corpuscular Volume, MCH Mean Corpuscular Haemoglobin, MCHC Mean Corpuscular Haemoglobin Concentration, RDW Red Cell Distribution Width, RBC Red Blood Cell Count, WBC White Blood Cell Count, ALP Alkaline Phosphatase, ALT Alanine Aminotransferase. P-values for changes within and between groups; significant (P < 0.05) values bolded. aLower counts in the Fish oil group; bHigher values in the Corn oil group. RV Reference value. ↑ Value increased significantly; ↓ Value decreased significantly