One-night sleep deprivation induces changes in the DNA methylation and serum activity indices of stearoyl-CoA desaturase in young healthy men

Table 1 Association between cytosine DNA methylation and SCD activity indices following one-night total sleep deprivation

Probe ID	Position	Relative TSS (bp)	Mean sleep % (sd)	Mean wake % (sd)	Slope	P-value	Slope	P-value
	Chr 10	NM_005063			SCD-16		SCD-18
	Chr 10	NM_005063			(16:1n-7/16:0)		(18:1n-9/18:0)
cg19191454	102106597	−175	4.4 (0.9)	4.2 (0.4)	0.016	<0.001	1.434	0.63
cg23508052	102106812	40	2.9 (0.5)	2.8 (0.5)	−0.003	0.01	−0.892	0.80
cg11311579	102106755	−17	0.8 (0.2)	1.0 (0.2)	−0.004	0.05	−6.887	0.38
cg01270221	102116383	9611	81.9 (1.3)	81.8 (1.2)	−0.092	0.07	−0.175	0.93
cg06400428	102107667	895	11.1 (3.5)	10.6 (3.6)	0.015	0.10	0.590	0.48
cg16744911	102108975	2203	82.0 (2.2)	82.4 (1.8)	0.025	0.19	0.213	0.87
cg03440556	102107758	986	27.6 (6.2)	26.6 (6.3)	0.039	0.25	−0.298	0.69
cg12714759	102102352	−4420	21.5 (3.9)	21.4 (3.8)	0.011	0.27	0.270	0.73
cg02237755	102107926	1154	83.1 (3.3)	83.1 (3.7)	0.048	0.55	−0.591	0.48
cg15022173	102101047	−5725	76.3 (2.2)	76.9 (2.4)	−0.420	0.56	−2.326	0.02
cg00653847	102100213	−6559	70.9 (4.1)	71.6 (3.5)	−0.025	0.61	−0.515	0.63
cg24503796	102107677	905	13.8 (3.2)	14.5 (2.9)	−0.018	0.65	0.766	0.53
cg07649988	102106577	−195	3.7 (0.7)	3.6 (0.8)	−0.019	0.72	8.026	0.05
cg14089512	102106758	−14	9.6 (1.1)	10.3 (1.2)	0.048	0.75	0.180	0.92
cg07230380	102106359	−413	0.7 (0.6)	0.9 (0.5)	0.004	0.92	1.160	0.75
cg18328965	102107585	813	11.0 (1.7)	10.8 (1.8)	0.221	0.93	1.902	0.14
cg00699831	102116399	9627	87.1 (1.1)	87.2 (1.3)	0.236	0.95	2.899	0.08
cg26351966	102106081	−691	18.2 (2.9)	18.7 (3.2)	0.017	0.96	0.050	0.97
cg00954566	102106406	−366	4.4 (0.9)	4.3 (0.9)	−0.002	0.97	0.474	0.90

The table shows selected SCD1 probes and SCD activity indices derived from serum phospholipids of young healthy men. Bold represents a statistically significant association at P < 0.05; software package R (version 3.1)

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