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Table 1 Differences in baseline characteristics between subjects with T2D and controls

From: The therapeutic efficacy of intensive medical therapy in ameliorating high-density lipoprotein dysfunction in subjects with type two diabetes

 

Overall (n = 22)

Control (n = 9)

D2M (n = 13)

 

Parameter

n

Summary

n

Summary

n

Summary

p-value

Fasting glucose (mg/dl)

22

147.0 [91.0,198.0]

9

90.0 [83.0,93.0]

13

180.0 [161.0,240.0]

< 0.001 b

BMI (kg/m2)

22

31.9 [26.4,37.0]

9

25.6 [21.2,26.9]

13

36.5 [33.4,37.5]

< 0.001 b

HDL-cholesterol (mg/dl)

22

44.5 [37.0,56.0]

9

63.0 [45.0,72.0]

13

41.0 [37.0,45.0]

0.005 b

Triglycerides (mg/dl)

22

141.5 [82.0,187.0]

9

74.0 [50.0,86.0]

13

174.0 [152.0,337.0]

0.008 b

HOMA

22

4.8 [1.3,14.8]

9

1.2 [1.1,1.5]

13

14.4 [6.8,22.0]

< 0.001 b

Total cholesterol (mg/dl)

22

180.0 [158.0,202.0]

9

175.0 [143.0,195.0]

13

187.0 [172.0,202.0]

0.32b

LDL-cholesterol (mg/dl)

21

95.0 [79.0,109.0]

8

85.0 [65.5,95.5]

13

104.0 [82.0,114.0]

0.15b

Fasting insulin (mU/l)

22

10.6 [6.3,34.3]

9

5.9 [5.4,7.1]

13

32.4 [16.9,41.5]

<0.001 b

Age (years)

22

49.0 [41.7,55.6]

9

46.0 [30.0,57.2]

13

51.1 [43.7,55.3]

0.37b

Female

22

15 (68.2)

9

7 (77.8)

13

8 (61.5)

0.65d

Systolic blood pressure (mmHG)

22

126.0 [115.0,138.0]

9

108.0 [104.0,115.0]

13

137.0 [133.0,156.0]

< 0.001 b

Diastolic blood pressure (mmHG)

22

76.0 [68.0,89.0]

9

66.0 [65.0,69.0]

13

89.0 [83.0,91.0]

< 0.001 b

MPO activity (mOD/μL/min)

21

8.3 [5.1,14.8]

9

11.8 [4.4,14.6]

12

6.5 [5.6,20.9]

0.31b

pHDL assay (RFU mg HDLc/min)

21

0.42 [0.28,0.50]

9

0.26 [0.25,0.34]

12

0.49 [0.42,0.54]

< 0.001 b

Cp activity (μmol.min-1/mL)

21

0.16 [0.14,0.18]

9

0.18 [0.14,0.25]

12

0.16 [0.14,0.17]

0.22b

PONI1 activity (nmole.min-1/μL)

21

0.01 [0.01,0.01]

9

0.01 [0.01,0.01]

12

0.01 [0.01,0.01]

0.15b

apoA-1 (mg/dl)

20

128.6 [114.8,143.7]

9

144.2 [129.4,174.5]

11

124.5 [111.4,128.7]

0.013 b

  1. Intent-to-treat analysis. Values presented as median [P25, P75] or n (column %)
  2. p-values: b = Wilcoxon rank sum test, d = Fisher’s exact test