Fig. 1
From: Clinical assessment of hepatic de novo lipogenesis in non-alcoholic fatty liver disease
The pathophysiology of NAFLD/NASH. Excess dietary saturated fat intake as well as increased adipose tissue lipolysis contributes to fat accumulation in the liver. Overconsumption of fructose leading to upregulated de novo lipogenesis (DNL) also adds to hepatic steatosis. Insulin resistance and oxidative stress fuel a lipotoxic environment within the liver, which can result in hepatic inflammation and injury leading to fibrosis